دورية أكاديمية
Metabolic Response in Patients With Post-treatment Lyme Disease Symptoms/Syndrome.
| العنوان: | Metabolic Response in Patients With Post-treatment Lyme Disease Symptoms/Syndrome. |
|---|---|
| المؤلفون: | Fitzgerald BL; Centers for Disease Control and Prevention, Fort Collins, Colorado, USA., Graham B; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA., Delorey MJ; Centers for Disease Control and Prevention, Fort Collins, Colorado, USA., Pegalajar-Jurado A; Centers for Disease Control and Prevention, Fort Collins, Colorado, USA., Islam MN; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA., Wormser GP; Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA., Aucott JN; The Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Lutherville, Maryland, USA., Rebman AW; The Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Lutherville, Maryland, USA., Soloski MJ; The Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Lutherville, Maryland, USA., Belisle JT; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA., Molins CR; Centers for Disease Control and Prevention, Fort Collins, Colorado, USA. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Oct 05; Vol. 73 (7), pp. e2342-e2349. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Lyme Disease*/diagnosis , Lyme Disease*/drug therapy , Post-Lyme Disease Syndrome*/drug therapy, Anti-Bacterial Agents/therapeutic use ; Chromatography, Liquid ; Cohort Studies ; Humans |
| مستخلص: | Background: Post-treatment Lyme disease symptoms/syndrome (PTLDS) occurs in approximately 10% of patients with Lyme disease following antibiotic treatment. Biomarkers or specific clinical symptoms to identify patients with PTLDS do not currently exist and the PTLDS classification is based on the report of persistent, subjective symptoms for ≥6 months following antibiotic treatment for Lyme disease. Methods: Untargeted liquid chromatography-mass spectrometry metabolomics was used to determine longitudinal metabolic responses and biosignatures in PTLDS and clinically cured non-PTLDS Lyme patients. Evaluation of biosignatures included (1) defining altered classes of metabolites, (2) elastic net regularization to define metabolites that most strongly defined PTLDS and non-PTLDS patients at different time points, (3) changes in the longitudinal abundance of metabolites, and (4) linear discriminant analysis to evaluate robustness in a second patient cohort. Results: This study determined that observable metabolic differences exist between PTLDS and non-PTLDS patients at multiple time points. The metabolites with differential abundance included those from glycerophospholipid, bile acid, and acylcarnitine metabolism. Distinct longitudinal patterns of metabolite abundance indicated a greater metabolic variability in PTLDS versus non-PTLDS patients. Small numbers of metabolites (6 to 40) could be used to define PTLDS versus non-PTLDS patients at defined time points, and the findings were validated in a second cohort of PTLDS and non-PTLDS patients. Conclusions: These data provide evidence that an objective metabolite-based measurement can distinguish patients with PTLDS and help understand the underlying biochemistry of PTLDS. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.) |
| References: | Clin Infect Dis. 2015 Dec 15;61(12):1800-6. (PMID: 26385994) Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5472-80. (PMID: 27573827) J Intern Med. 2011 Jul;270(1):76-84. (PMID: 21205027) Am J Pathol. 2018 Mar;188(3):672-682. (PMID: 29242055) Clin Infect Dis. 2016 Dec 1;63(11):1399-1404. (PMID: 27585799) Lancet Infect Dis. 2016 May;16(5):556-564. (PMID: 26856777) Sci Rep. 2018 Jul 3;8(1):10056. (PMID: 29968805) Nucleic Acids Res. 2013 Jan;41(Database issue):D801-7. (PMID: 23161693) mBio. 2020 Mar 17;11(2):. (PMID: 32184234) Environ Sci Technol. 2014 Feb 18;48(4):2097-8. (PMID: 24476540) Sci Rep. 2019 May 29;9(1):8049. (PMID: 31142787) PLoS One. 2011 Mar 31;6(3):e18220. (PMID: 21483819) J Clin Invest. 2012 Jul;122(7):2652-60. (PMID: 22728937) J Stat Softw. 2010;33(1):1-22. (PMID: 20808728) Sci Rep. 2018 Aug 15;8(1):12204. (PMID: 30111850) Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2320-E2328. (PMID: 29444855) J Neuroinflammation. 2018 Dec 19;15(1):346. (PMID: 30567544) Brain Behav Immun. 2010 Aug;24(6):1018-24. (PMID: 20227484) Clin Infect Dis. 2020 Dec 15;71(12):3118-3124. (PMID: 31996890) Clin Infect Dis. 2006 Nov 1;43(9):1089-134. (PMID: 17029130) Arch Clin Neuropsychol. 2017 Mar 01;32(2):129-141. (PMID: 28365751) PLoS One. 2016 May 19;11(5):e0155694. (PMID: 27196316) J Proteome Res. 2020 Feb 7;19(2):610-623. (PMID: 31821002) PLoS Comput Biol. 2013;9(7):e1003123. (PMID: 23861661) Front Med (Lausanne). 2019 Dec 06;6:283. (PMID: 31867334) Clin Infect Dis. 2015 Jun 15;60(12):1767-75. (PMID: 25761869) Clin Vaccine Immunol. 2016 Sep 06;23(9):757-66. (PMID: 27358211) Qual Life Res. 2013 Feb;22(1):75-84. (PMID: 22294245) Metabolomics. 2018 Sep 20;14(10):128. (PMID: 30830398) Mol Biosyst. 2017 Jan 31;13(2):371-379. (PMID: 28059425) Sci Transl Med. 2017 Aug 16;9(403):. (PMID: 28814545) Nat Rev Dis Primers. 2016 Dec 15;2:16090. (PMID: 27976670) mBio. 2016 Feb 12;7(1):e00100-16. (PMID: 26873097) Clin Infect Dis. 2018 Sep 28;67(8):1309-1310. (PMID: 29741589) Clin Infect Dis. 2014 Feb;58(3):372-80. (PMID: 24218102) |
| معلومات مُعتمدة: | P30 AR070254 United States AR NIAMS NIH HHS; R01 AI141656 United States AI NIAID NIH HHS; R33 AI100228 United States AI NIAID NIH HHS; United States CC CDC HHS |
| فهرسة مساهمة: | Keywords: Borrelia burgdorferi; Lyme disease; PTLDS; metabolomics |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20200925 Date Completed: 20211020 Latest Revision: 20231107 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8492154 |
| DOI: | 10.1093/cid/ciaa1455 |
| PMID: | 32975577 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
|---|---|
| DOI: | 10.1093/cid/ciaa1455 |