دورية أكاديمية
أعرض في EDS

Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease.

التفاصيل البيبلوغرافية
العنوان: Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease.
المؤلفون: Miller DJ; Department of Foundational Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI 48858, USA., Cascio MA; Department of Foundational Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI 48858, USA., Rosca MG; Department of Foundational Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI 48858, USA.
المصدر: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2020 Sep 23; Vol. 9 (10). Date of Electronic Publication: 2020 Sep 23.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Diabetic retinopathy (DR), a common chronic complication of diabetes mellitus and the leading cause of vision loss in the working-age population, is clinically defined as a microvascular disease that involves damage of the retinal capillaries with secondary visual impairment. While its clinical diagnosis is based on vascular pathology, DR is associated with early abnormalities in the electroretinogram, indicating alterations of the neural retina and impaired visual signaling. The pathogenesis of DR is complex and likely involves the simultaneous dysregulation of multiple metabolic and signaling pathways through the retinal neurovascular unit. There is evidence that microvascular disease in DR is caused in part by altered energetic metabolism in the neural retina and specifically from signals originating in the photoreceptors. In this review, we discuss the main pathogenic mechanisms that link alterations in neural retina bioenergetics with vascular regression in DR. We focus specifically on the recent developments related to alterations in mitochondrial metabolism including energetic substrate selection, mitochondrial function, oxidation-reduction (redox) imbalance, and oxidative stress, and critically discuss the mechanisms of these changes and their consequences on retinal function. We also acknowledge implications for emerging therapeutic approaches and future research directions to find novel mitochondria-targeted therapeutic strategies to correct bioenergetics in diabetes. We conclude that retinal bioenergetics is affected in the early stages of diabetes with consequences beyond changes in ATP content, and that maintaining mitochondrial integrity may alleviate retinal disease.
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معلومات مُعتمدة: 18AIREA33990023 American Heart Association
فهرسة مساهمة: Keywords: diabetic retinopathy; mitochondria; oxidative stress; photoreceptor; redox
تواريخ الأحداث: Date Created: 20200926 Latest Revision: 20211217
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7598160
DOI: 10.3390/antiox9100905
PMID: 32977483
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3921
DOI:10.3390/antiox9100905