دورية أكاديمية
Reduced Activation of the Synaptic-Type GABA A Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization.
العنوان: | Reduced Activation of the Synaptic-Type GABA |
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المؤلفون: | Pierce SR; Department of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri., Germann AL; Department of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri., Evers AS; Department of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri., Steinbach JH; Department of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri., Akk G; Department of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu. |
المصدر: | Molecular pharmacology [Mol Pharmacol] 2020 Dec; Vol. 98 (6), pp. 762-769. Date of Electronic Publication: 2020 Sep 25. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Bethesda, MD : American Society for Pharmacology and Experimental Therapeutics |
مواضيع طبية MeSH: | GABA-A Receptor Agonists/*pharmacology , Receptors, GABA-A/*metabolism , Synaptic Potentials/*drug effects, Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Humans ; Oocytes ; Patch-Clamp Techniques ; Pregnanolone/pharmacology ; Recombinant Proteins/metabolism ; Time Factors ; Xenopus laevis ; gamma-Aminobutyric Acid/pharmacology |
مستخلص: | Synaptic GABA (Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.) |
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معلومات مُعتمدة: | R01 GM108580 United States GM NIGMS NIH HHS; R01 GM108799 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (GABA-A Receptor Agonists) 0 (Receptors, GABA-A) 0 (Recombinant Proteins) 56-12-2 (gamma-Aminobutyric Acid) BXO86P3XXW (Pregnanolone) |
تواريخ الأحداث: | Date Created: 20200926 Date Completed: 20201211 Latest Revision: 20211203 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7673486 |
DOI: | 10.1124/molpharm.120.000088 |
PMID: | 32978327 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1521-0111 |
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DOI: | 10.1124/molpharm.120.000088 |