دورية أكاديمية
Genetic variability of molecules involved in the disease pathogenesis in Leishmania infection.
العنوان: | Genetic variability of molecules involved in the disease pathogenesis in Leishmania infection. |
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المؤلفون: | Sánchez Luquez KY; Laboratorio de Fisiopatología. Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela., Zerpa O; Servicio Autónomo Instituto de Biomedicina Dr. Jacinto Convit, Venezuela., Paz-Villarraga CA; Instituto De Biología Experimental (IBE), Universidad Central de Venezuela, Venezuela., Fernández-Mestre M; Laboratorio de Fisiopatología. Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. Electronic address: mfernandezmestre@gmail.com. |
المصدر: | Experimental parasitology [Exp Parasitol] 2020 Nov; Vol. 218, pp. 108007. Date of Electronic Publication: 2020 Sep 23. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2449 (Electronic) Linking ISSN: 00144894 NLM ISO Abbreviation: Exp Parasitol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Orlando, FL : Academic Press Original Publication: New York. |
مواضيع طبية MeSH: | Genetic Variation*, Leishmaniasis, Cutaneous/*genetics, Adolescent ; Adult ; Aged ; Aged, 80 and over ; CD40 Antigens/genetics ; CD40 Antigens/metabolism ; Case-Control Studies ; Child ; Child, Preschool ; Endemic Diseases ; Female ; Gene Frequency ; Humans ; Leishmaniasis, Cutaneous/etiology ; Male ; Middle Aged ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Rural Population ; Sequence Alignment ; Suppressor of Cytokine Signaling 1 Protein/genetics ; Suppressor of Cytokine Signaling 1 Protein/metabolism ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Toll-Like Receptors/genetics ; Toll-Like Receptors/metabolism ; Venezuela ; Young Adult |
مستخلص: | Macrophages are the primary host cell for Leishmania parasites, by Toll like receptors (TLR-MyD88) that are central components of the innate and adaptive immunity against leishmania infection. The CD40/CD40L interaction has also been shown to be important in resistance to various protozoa. In this context, one of the most important properties of suppressors of cytokine signalling (SOCS) proteins, especially SOCS1 and SOCS3, is the regulation of macrophages cell for Leishmania parasites. In the present study we evaluated variants of molecules involved in activation and modulation of leishmanicidal signaling cascades and the possible associations between polymorphisms present in the TLR2, TLR4, MyD88, CD40, SOCS1, SOCS3 genes with susceptibility/resistent to Leishmania. The results suggest the absence of any association between TLR2 and TLR4 variants and susceptibility to Leishmaniasis. Analysis of the nucleotide sequence encoding the TIR recognition domain of the MyD88 molecule showed that it is highly conserved when compared to the reference sequences. In contrast, heterozygous rs 12953258, which reflects a decrease in the expression of SOCS3, suggesting that it may be involved in the leishmaniasis susceptibility. This study is a first advance in the analysis of polymorphisms of genes involved in the signaling pathway of the macrophage and their relationship with leishmaniases infection and disease progression. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
فهرسة مساهمة: | Keywords: Cytokine signalling; Host immune responses; Leishmania asymptomatic; Leishmania infection; Polymorphism |
المشرفين على المادة: | 0 (CD40 Antigens) 0 (SOCS1 protein, human) 0 (SOCS3 protein, human) 0 (Suppressor of Cytokine Signaling 1 Protein) 0 (Suppressor of Cytokine Signaling 3 Protein) 0 (Toll-Like Receptors) |
تواريخ الأحداث: | Date Created: 20200926 Date Completed: 20201109 Latest Revision: 20201109 |
رمز التحديث: | 20240628 |
DOI: | 10.1016/j.exppara.2020.108007 |
PMID: | 32979344 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1090-2449 |
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DOI: | 10.1016/j.exppara.2020.108007 |