دورية أكاديمية
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Thyroid hormone, gene expression, and Central Nervous System: Where we are.

التفاصيل البيبلوغرافية
العنوان: Thyroid hormone, gene expression, and Central Nervous System: Where we are.
المؤلفون: Giannocco G; Departamento de Medicina, Laboratório de Endocrinologia e Medicina Translacional, Universidade Federal de São Paulo, UNIFESP/EPM, Rua Pedro de Toledo, 669 - 11 andar, São Paulo, SP 04039-032, Brazil; Departamento de Ciências Biológicas, Universidade Federal de São Paulo, UNIFESP, Diadema, SP 09920-000, Brazil., Kizys MML; Departamento de Medicina, Laboratório de Endocrinologia e Medicina Translacional, Universidade Federal de São Paulo, UNIFESP/EPM, Rua Pedro de Toledo, 669 - 11 andar, São Paulo, SP 04039-032, Brazil., Maciel RM; Departamento de Medicina, Laboratório de Endocrinologia e Medicina Translacional, Universidade Federal de São Paulo, UNIFESP/EPM, Rua Pedro de Toledo, 669 - 11 andar, São Paulo, SP 04039-032, Brazil., de Souza JS; Departamento de Medicina, Laboratório de Endocrinologia e Medicina Translacional, Universidade Federal de São Paulo, UNIFESP/EPM, Rua Pedro de Toledo, 669 - 11 andar, São Paulo, SP 04039-032, Brazil; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jsenadesouza@ucsd.edu.
المصدر: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2021 Jun; Vol. 114, pp. 47-56. Date of Electronic Publication: 2020 Sep 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 9607332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3634 (Electronic) Linking ISSN: 10849521 NLM ISO Abbreviation: Semin Cell Dev Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Academic Press
Original Publication: London, UK : Academic Press, c1996-
مواضيع طبية MeSH: Central Nervous System/*physiology , Gene Expression/*genetics , Thyroid Hormones/*therapeutic use, Animals ; Humans ; Mice ; Thyroid Hormones/pharmacology
مستخلص: Thyroid hormones (TH; T3 and T4) play a fundamental role in the fetal stage to the adult phase, controlling gene and protein expression in virtually all tissues. The endocrine and CNS systems have relevant interaction, and the TH are pivotal for the proper functioning of the CNS. A slight failure to regulate TH availability during pregnancy and/or childhood can lead to neurological disorders, for example, autism and cognitive impairment, or depression. In this review, we highlight how TH acts in controlling gene expression, its role in the CNS, and what substances widely found in the environment can cause in this tissue. We highlight the role of Endocrine Disruptors used on an everyday basis in the processing of mRNAs responsible for neurodevelopment. We conclude that TH, more precisely T3, acts mainly throughout its nuclear receptors, that the deficiency of this hormone, either due to the lack of its main substrate iodine, or by to incorrect organification of T4 and T3 in the gland, or by a mutation in transporters, receptors and deiodinases may cause mild (dysregulated mood in adulthood) to severe neurological impairment (Allan-Herndon-Dudley syndrome, presented as early as childhood); T3 is responsible for the expression of numerous CNS genes related to oxygen transport, growth factors, myelination, cell maturation. Substances present in the environment and widely used can interfere with the functioning of the thyroid gland, the action of TH, and the functioning of the CNS.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Brain; Endocrine disruptors; Neurodevelopment; Receptors; Thyroid hormone; mRNA
المشرفين على المادة: 0 (Thyroid Hormones)
تواريخ الأحداث: Date Created: 20200927 Date Completed: 20220202 Latest Revision: 20220202
رمز التحديث: 20231215
DOI: 10.1016/j.semcdb.2020.09.007
PMID: 32980238
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-3634
DOI:10.1016/j.semcdb.2020.09.007