دورية أكاديمية
أعرض في EDS

Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children.

التفاصيل البيبلوغرافية
العنوان: Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children.
المؤلفون: Parikh NA; Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, USA. Nehal.Parikh@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Nehal.Parikh@cchmc.org., Harpster K; Division of Occupational Therapy and Physical Therapy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., He L; Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Illapani VSP; Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, USA., Khalid FC; Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, USA., Klebanoff MA; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Departments of Pediatrics and Obstetrics and Gynecology, The Ohio State University, Columbus, OH, USA., O'Shea TM; Departments of Pediatrics, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Altaye M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
المصدر: Scientific reports [Sci Rep] 2020 Sep 28; Vol. 10 (1), pp. 15920. Date of Electronic Publication: 2020 Sep 28.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Brain/*diagnostic imaging , Child Development/*physiology , Motor Skills/*physiology , White Matter/*diagnostic imaging, Biomarkers ; Child, Preschool ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging ; Male
مستخلص: Our objective was to evaluate the independent prognostic value of a novel MRI biomarker-objectively diagnosed diffuse white matter abnormality volume (DWMA; diffuse excessive high signal intensity)-for prediction of motor outcomes in very preterm infants. We prospectively enrolled a geographically-based cohort of very preterm infants without severe brain injury and born before 32 weeks gestational age. Structural brain MRI was obtained at term-equivalent age and DWMA volume was objectively quantified using a published validated algorithm. These results were compared with visually classified DWMA. We used multivariable linear regression to assess the value of DWMA volume, independent of known predictors, to predict motor development as assessed using the Bayley Scales of Infant & Toddler Development, Third Edition at 3 years of age. The mean (SD) gestational age of the cohort was 28.3 (2.4) weeks. In multivariable analyses, controlling for gestational age, sex, and abnormality on structural MRI, DWMA volume was an independent prognostic biomarker of Bayley Motor scores ([Formula: see text]= -12.59 [95% CI -18.70, -6.48] R 2  = 0.41). Conversely, visually classified DWMA was not predictive of motor development. In conclusion, objectively quantified DWMA is an independent prognostic biomarker of long-term motor development in very preterm infants and warrants further study.
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معلومات مُعتمدة: R01 NS094200 United States NS NINDS NIH HHS; R21-HD094085 United States NH NIH HHS; R21 HD094085 United States HD NICHD NIH HHS; R01-NS094200 United States NH NIH HHS; R01 NS096037 United States NS NINDS NIH HHS
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20200928 Date Completed: 20201224 Latest Revision: 20210928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7523012
DOI: 10.1038/s41598-020-72632-0
PMID: 32985533
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-72632-0