دورية أكاديمية
Radiotherapy Practice for Treatment of Bone Metastasis in Ethiopia.
| العنوان: | Radiotherapy Practice for Treatment of Bone Metastasis in Ethiopia. |
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| المؤلفون: | Rick TJ; Department of Radiation Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Habtamu B; Department of Radiation Oncology, Addis Ababa University, Addis Ababa, Ethiopia., Tigeneh W; Department of Radiation Oncology, Addis Ababa University, Addis Ababa, Ethiopia., Abreha A; Department of Radiation Oncology, Addis Ababa University, Addis Ababa, Ethiopia., Grover S; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Assefa M; Department of Radiation Oncology, Addis Ababa University, Addis Ababa, Ethiopia., Heemsbergen W; Department of Radiation Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Incrocci L; Department of Radiation Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands. |
| المصدر: | JCO global oncology [JCO Glob Oncol] 2020 Sep; Vol. 6, pp. 1422-1427. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101760170 Publication Model: Print Cited Medium: Internet ISSN: 2687-8941 (Electronic) Linking ISSN: 26878941 NLM ISO Abbreviation: JCO Glob Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Alexandria, VA : American Society of Clinical Oncology, [2020]- |
| مواضيع طبية MeSH: | Bone Neoplasms*/radiotherapy , Radiation Oncology*, Dose Fractionation, Radiation ; Ethiopia ; Female ; Humans ; Male ; Retrospective Studies |
| مستخلص: | Purose: Ethiopia has one cobalt radiotherapy (RT) machine to serve a population of more than 100 million. The purpose of this study was to report on patterns of palliative RT of bone metastasis in a severely low-capacity setting. Patients and Methods: Patient and treatment characteristics of patients irradiated for palliation of symptomatic bone metastasis were extracted from a retrospective database of patients treated between May 2015 and January 2018. This database included a random sample of 1,823 of the estimated 4,000 patients who were treated with RT within in the study period. Associations between the applied RT schedule and patient and tumor characteristics were evaluated with the χ 2 test. Hypothetical savings of RT sessions and time were compared in the case of a single-fraction policy. Results: From the database, 234 patients (13%) were treated for bone metastasis. Most patients were ≤ 65 years of age (n = 189; 80%) and female (n = 125; 53%). The most common primary sites were breast (n = 82; 35%) and prostate (n = 36; 15%). Fractionated regimens were preferred over single fraction: 20 Gy in 5 fractions (n = 192; 82.1%), 30 Gy in 10 fractions (n = 7; 3%), and 8 Gy in 1 fraction (n = 28; 12%). Factors associated with single-fraction RT included nonaxial sites of bone metastasis ( P < .01) and an address outside Addis Ababa ( P ≤ .01). If single-fraction RT would have been given uniformly for bone metastasis, this would have resulted in a 78% reduction in the number of RT sessions and 76% reduction in total RT time. Conclusion: The pattern of palliative RT for bone metastasis in Ethiopia favors fractionated regimens over single fraction. Efforts should be made to adopt evidence-based and cost-effective guidelines. |
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| معلومات مُعتمدة: | K08 CA230170 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20200928 Date Completed: 20210728 Latest Revision: 20210728 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7529534 |
| DOI: | 10.1200/GO.20.00204 |
| PMID: | 32986515 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2687-8941 |
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| DOI: | 10.1200/GO.20.00204 |