دورية أكاديمية
COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts.
العنوان: | COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts. |
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المؤلفون: | Silva EMVM; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Lacerda RHW; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Farias IL; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Cavalcante BGN; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Assis IO; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Bezamat M; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA, 15261, USA., Modesto A; Department of Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Vieira AR; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil. arv11@pitt.edu.; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA, 15261, USA. arv11@pitt.edu. |
المصدر: | Oral and maxillofacial surgery [Oral Maxillofac Surg] 2021 Jun; Vol. 25 (2), pp. 253-256. Date of Electronic Publication: 2020 Sep 29. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101319632 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-1569 (Electronic) Linking ISSN: 18651550 NLM ISO Abbreviation: Oral Maxillofac Surg Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : Springer-Verlag |
مواضيع طبية MeSH: | Alveolar Bone Grafting* , Cleft Lip*/genetics , Cleft Lip*/surgery , Cleft Palate*/genetics , Cleft Palate*/surgery, Bone Transplantation ; Catechol O-Methyltransferase/genetics ; Humans ; Ilium |
مستخلص: | Purpose: Verifying whether the mutation in COMT rs4818 could be involved in pain modulation. Methods: Thirty-two individuals born with cleft lip and palate that underwent bone graft from the iliac crest bone were assessed at 12, 24, 48, 72 h, and 7 days regarding their pain experience using a visual analogic scale. DNA from each participant was collected from saliva samples, and genotyping of rs4818 was performed using TaqMan chemistry. Overrepresentation of rs4818 alleles was tested using chi-square or Fisher's exact tests with an alpha of 0.05. Results: Of the 32 individuals, eighteen reported long pain duration, nine reported high pain intensity, and fourteen low pain intensity up to 48 h. No differences were found in the distribution of individuals depending on the reported pain by sex (p = 0.12), age (p = 0.42), or cleft type (p = 0.5). The distribution of COMT r4818 alleles was different depending on the intensity and duration of pain. Carriers of the C wild-type allele were four times more likely to show high pain intensity and duration (odds ratio = 4.29, 95% confidence interval 1.13-16.18), meaning that the G variant allele is protective. Conclusion: COMT rs4818 is associated with postoperative pain after alveolar bone grafting. |
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فهرسة مساهمة: | Keywords: Bone graft; COMT; Cleft lip and palate; Genetics; Pain |
المشرفين على المادة: | EC 2.1.1.6 (COMT protein, human) EC 2.1.1.6 (Catechol O-Methyltransferase) |
تواريخ الأحداث: | Date Created: 20200929 Date Completed: 20210518 Latest Revision: 20220531 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s10006-020-00912-0 |
PMID: | 32989615 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1865-1569 |
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DOI: | 10.1007/s10006-020-00912-0 |