دورية أكاديمية
COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts.
| العنوان: | COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts. |
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| المؤلفون: | Silva EMVM; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Lacerda RHW; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Farias IL; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Cavalcante BGN; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Assis IO; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Bezamat M; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA, 15261, USA., Modesto A; Department of Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Vieira AR; Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil. arv11@pitt.edu.; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA, 15261, USA. arv11@pitt.edu. |
| المصدر: | Oral and maxillofacial surgery [Oral Maxillofac Surg] 2021 Jun; Vol. 25 (2), pp. 253-256. Date of Electronic Publication: 2020 Sep 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101319632 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-1569 (Electronic) Linking ISSN: 18651550 NLM ISO Abbreviation: Oral Maxillofac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer-Verlag |
| مواضيع طبية MeSH: | Alveolar Bone Grafting* , Cleft Lip*/genetics , Cleft Lip*/surgery , Cleft Palate*/genetics , Cleft Palate*/surgery, Bone Transplantation ; Catechol O-Methyltransferase/genetics ; Humans ; Ilium |
| مستخلص: | Purpose: Verifying whether the mutation in COMT rs4818 could be involved in pain modulation. Methods: Thirty-two individuals born with cleft lip and palate that underwent bone graft from the iliac crest bone were assessed at 12, 24, 48, 72 h, and 7 days regarding their pain experience using a visual analogic scale. DNA from each participant was collected from saliva samples, and genotyping of rs4818 was performed using TaqMan chemistry. Overrepresentation of rs4818 alleles was tested using chi-square or Fisher's exact tests with an alpha of 0.05. Results: Of the 32 individuals, eighteen reported long pain duration, nine reported high pain intensity, and fourteen low pain intensity up to 48 h. No differences were found in the distribution of individuals depending on the reported pain by sex (p = 0.12), age (p = 0.42), or cleft type (p = 0.5). The distribution of COMT r4818 alleles was different depending on the intensity and duration of pain. Carriers of the C wild-type allele were four times more likely to show high pain intensity and duration (odds ratio = 4.29, 95% confidence interval 1.13-16.18), meaning that the G variant allele is protective. Conclusion: COMT rs4818 is associated with postoperative pain after alveolar bone grafting. |
| References: | Augsornwan D, Pattangtanang P, Pikhunthod K, Surakunprapha P (2011) Postoperative pain in patients with cleft lip and palate in Srinagarind hospital. J Med Assoc Thail 94:118–123. Gong C, Yan M, Jiang F, Chen Z, Long Y, Chen L, Zheng Q, Shi B (2014) Nursing intervention and evaluation of postoperative pain in preschool children with cleft lip and palate. Hua Xi KouQiang Yi XueZaZhi 32:263–266. https://doi.org/10.7518/hxkq.2014.03.013. (PMID: 10.7518/hxkq.2014.03.013) Fortes LM, Carril AL, Tellado MG, Beloy IC, Portals CB, González MG, Ruiz MR, Argibay IS, Carbonell TD (2019) Parent controlled analgesia system in postoperative pain management in patients undergoing lip and cleft palate surgery. Cir Pediatr 32:22–27. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W (2005) Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 14:135–114. (PMID: 10.1093/hmg/ddi013) Michelotti A, Liguori R, Toriello M, D’Antò V, Vitale D, Castaldo G, Sacchetti L (2014) Catechol-O-methyltransferase (COMT) gene polymorphisms as risk factor in temporomandibular disorders patients from Southern Italy. Clin J Pain 30:129–133. https://doi.org/10.1097/AJP.0b013e318287a358. (PMID: 10.1097/AJP.0b013e318287a35823446089) Mladenovic I, Supic G, Kozomara R, Dodic S, Ivkovic N, Milicevic B, Simic I, Magic Z (2016) Genetic polymorphisms of cathechol-O-methyltransferase: association with temporomandibular disorders and postoperative pain. J Oral Facial Pain Headache 30:302–310. https://doi.org/10.11607/ofph.1688. (PMID: 10.11607/ofph.168827792797) Nascimento TD, Yang N, Salman D, Jassar H, Kaciroti N, Bellile E, Danciu T, Koeppe R, Stohler C, Zubieta JK, Ellingrod V, DaSilva AF (2019) μ-Opioid activity in chronic TMD pain is associated with COMT polymorphism. J Dent Res 98:1324–1331. https://doi.org/10.1177/0022034519871938. (PMID: 10.1177/0022034519871938314906996806132) Tesch RS, Bonato LL, Quinelato V, Casado PL, Vieira AR, Granjeiro JM, Góes C (2020) Evaluation of genetic risk related to cathecol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients. Int J Oral Maxillofac Surg 49:237–243. https://doi.org/10.1016/j.ijom.2019.06.027. (PMID: 10.1016/j.ijom.2019.06.027) Bonato LL, Quinelato V, Cordeiro PCF, Vieira AR, Granjeiro JM, Tesch R et al (2019) Polymorphisms in COMT, ADRB2 and HTR1A genes are associated with temporomandibular disorders in individuals with other arthralgias. Cranio 2:1–11. https://doi.org/10.1080/08869634.2019.1632406. (PMID: 10.1080/08869634.2019.1632406) Slade GD, Sanders AE, Ohrbach R, Bair E, Maixner W, Greenspan JD, Fillingim RB, Smith S, Diatchenko L (2015) COMT diplotype amplifies effect of stress on risk of temporomandibular pain. J Dent Res 94:1187–1195. https://doi.org/10.1177/0022034515595043. (PMID: 10.1177/0022034515595043261983904547321) Brancher JA, Spada PP, Meger MN, Fatturri AL, Dalledone M, Bertoli FMP et al (2019) The association of genetic polymorphisms in serotonin transporter and cathechol-O-methyltransferase on temporomandibular disorders and anxiety in adolescents. J Oral Rehabil 46:597–604. https://doi.org/10.1111/joor.12783. (PMID: 10.1111/joor.1278330811655) Mladenovic I, Krunic J, Supic G, Kozomara R, Bokonjic D, Stojanovic N, Magic Z (2018) Pulp sensitivity: influence of sex, psychosocial variables, COMT gene, and chronic facial pain. J Endod 44:717–721. https://doi.org/10.1016/j.joen.2018.02.002. (PMID: 10.1016/j.joen.2018.02.00229550002) Raggi MC, González R, Hohl DM, Glesmann LA, Catanesi CI (2018) Genetic variations of OPRM1, OPRK1, and COMT genes and their possible associations with oral pain in a population from Argentina. J Oral Facial Pain Headache 32:367–374. https://doi.org/10.11607/ofph.1902. (PMID: 10.11607/ofph.1902) Govil M, Mukhopadhyay N, Holwerda T, Sluka K, Rakel B, Schutte DL (2020) Effects of genotype on TENS effectiveness in controlling knee pain in persons with mild to moderate osteoarthritis. Eur J Pain 24:398–412. https://doi.org/10.1002/ejp.1497. (PMID: 10.1002/ejp.149731661578) Schutte DL, Mukhopadhyay N, Holwerda T, Sluka K, Rakel B, Govil M (2020) Genetic predictors of knee pain in persons with mild to moderate osteoarthritis. Res Gerontol Nurs 13:191–202. https://doi.org/10.3928/19404921-20200312-01. (PMID: 10.3928/19404921-20200312-01) Margarit C, Roca R, Inda MD, Muriel J, Ballester P, Moreu R, Conte AL et al (2019) Genetic contribution in low back pain: a prospective genetic association study. Pain Pract 19:836–847. https://doi.org/10.1111/papr.12816. (PMID: 10.1111/papr.1281631269327) Baumbauer KM, Ramesh D, Perry M, Carney KB, Julian T, Glidden N, Dorsey SG, Starkweather AR, Young EE (2020) Contribution of COMT and BDNF genotype and expression to the risk of transition from acute to chronic low back pain. Clin J Pain 36:430–439. https://doi.org/10.1097/AJP.0000000000000819. (PMID: 10.1097/AJP.0000000000000819320799987211115) Margarit C, Roca R, Inda MD, Muriel J, Ballester P, Flor A, Morales D, Peiró AM (2020) Gender bias and genotype influence on opioid safety profile in chronic low back pain. Clin J Pain. https://doi.org/10.1097/AJP.0000000000000824. Lee C, Liptan G, Kantorovich S, Sharma M, Brenton A (2018) Association of catechol-O-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients. BMC Rheumatol 2:38. https://doi.org/10.1186/s41927-018-0045-4. (PMID: 10.1186/s41927-018-0045-4308869886390547) Xu J, Umlauf A, Letendre S, Franklin D, Bush WS, Atkinson JH, Keltner J, Ellis RJ (2019) Catechol-O-methyltransferase polymorphism Val158Met is associated with distal neuropathic pain in HIV-associated sensory neuropathy. AIDS 33:1575–1582. https://doi.org/10.1097/QAD.0000000000002240. (PMID: 10.1097/QAD.0000000000002240310218497380251) Lucenteforte E, Vannacci A, Crescioli G, Lombardi N, Vagnoli L, Giunti L, Cetica V, Coniglio ML, Pugi A, Bonaiuti R, Aricò M, Giglio S, Messeri A, Barale R, Giovannelli L, Mugelli A, Maggini V (2019) Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review. BMC Cancer 19:113. https://doi.org/10.1186/s12885-019-5310-4. (PMID: 10.1186/s12885-019-5310-4307044366357360) Matic M, de Hoogd S, de Wildt SN, Tibboel D, Knibbe CA, Van Schaik RH (2020) OPRM1 and COMT polymorphisms: implications on postoperative acute, chronic and experimental pain after cardiac surgery. Pharmacogenomics 21:181–193. https://doi.org/10.2217/pgs-2019-0141. (PMID: 10.2217/pgs-2019-014131967515) Hoofwijk DMN, Van Reij RRI, Rutten BPF, Kenis G, Theunissen M, Joosten EA et al (2019) Genetic polymorphisms and prediction of chronic post-surgical pain after hysterectomy-a subgroup analysis of a multicenter cohort study. Acta Anaesthesiol Scand 63:1063–1073. https://doi.org/10.1111/aas.13413. (PMID: 10.1111/aas.1341331206175) Wang L, Wei C, Xiao F, Chang X, Zhang Y (2019) Influences of COMT rs4680 and OPRM1 rs1799971 polymorphisms on chronic postsurgical pain, acute pain, and analgesic consumption after elective cesarean delivery. Clin J Pain 35:31–36. https://doi.org/10.1097/AJP.0000000000000654. (PMID: 10.1097/AJP.000000000000065430234521) Knisely MR, Conley YP, Smoot B, Paul SM, Levine JD, Miaskowski C (2019) Associations between catecholaminergic and serotonergic genes and persistent arm pain severity following breast cancer surgery. J Pain 20:1100–1111. https://doi.org/10.1016/j.jpain.2019.03.008. (PMID: 10.1016/j.jpain.2019.03.008309045186736756) Van Hout WMMT, Mink van DerMolen AB, Breugem CC, Koole R, Van Cann EM (2011) Reconstruction of the alveolar cleft: can growth factor-aided tissue engineering replace autologous bone grafting? A literature review and systematic review of results obtained with bone morphogenetic protein-2. Clin Oral Investig 15:297–303. https://doi.org/10.1007/s00784-011-0547-6. (PMID: 10.1007/s00784-011-0547-6214652203089722) Boyne PJ, Sands NR (1972) Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg 2:87–92. Vandeputte T, Bigorre M, Tramini P, Captier G (2020) Comparison between combined cortical and cancellous bone graft and cancellous bone graft in alveolar cleft: retrospective study of complications during the first six months post-surgery. J Craniomaxillofac Surg 48:38–42. https://doi.org/10.1016/j.jcms.2019.11.013. (PMID: 10.1016/j.jcms.2019.11.01331874807) Horn-Hofmann C, Scheel J, Dimova V, Parthum A, Carbon R, Griessinger N, Sittl R, Lautenbacher S (2017) Prediction of persistent post-operative pain: pain-specific psychological variables compared with acute post-operative pain and general psychological variables. Eur J Pain 22:191–202. https://doi.org/10.1002/ejp.1115. (PMID: 10.1002/ejp.111528940665) Ranade K, Chang MS, Ting CT, Pei D, Xsiao CF, Olivier M, Pesich R, Hebert J, Chen YD et al (2001) High-throughput genotyping with single nucleotide polymorphisms. Genome Res 11:1262–1268. https://doi.org/10.1101/gr.157801. (PMID: 10.1101/gr.15780111435409311112) Tunbridge EM (2010) The catechol-O-methyltransferase gene: its regulation and polymorphisms. Int Rev Neurobiol 95:7–27. https://doi.org/10.1016/B978-0-12-381326-8.00002-8. (PMID: 10.1016/B978-0-12-381326-8.00002-821095457) Sadhasivam S, Chidambaran VA, Olbrecht V, Esslinger HR, Zhang K, Zhang X, Martin LJ (2014) Genetics of pain perception, COMT and postoperative pain management in children. Pharmacogenomics 15:277–284. https://doi.org/10.2217/pgs.13.248. (PMID: 10.2217/pgs.13.248245337074151110) Vieira AR (2020) Genetic basis of orofacial pain and temporomandibular joint dysfunction. In: Vieira AR (ed) Genetic basis of oral health conditions. Springer, Chum, pp 81–92. |
| فهرسة مساهمة: | Keywords: Bone graft; COMT; Cleft lip and palate; Genetics; Pain |
| المشرفين على المادة: | EC 2.1.1.6 (COMT protein, human) EC 2.1.1.6 (Catechol O-Methyltransferase) |
| تواريخ الأحداث: | Date Created: 20200929 Date Completed: 20210518 Latest Revision: 20220531 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10006-020-00912-0 |
| PMID: | 32989615 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1865-1569 |
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| DOI: | 10.1007/s10006-020-00912-0 |