دورية أكاديمية
Characteristics and Graft Survival of Kidney Transplant Recipients with Renal Cell Carcinoma.
| العنوان: | Characteristics and Graft Survival of Kidney Transplant Recipients with Renal Cell Carcinoma. |
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| المؤلفون: | Machhi R; Department of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Wisconsin, Madison, Wisconsin, USA., Mandelbrot DA; Department of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Wisconsin, Madison, Wisconsin, USA., Al-Qaoud T; Department of Surgery, Division of Transplant Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Astor BC; Department of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Wisconsin, Madison, Wisconsin, USA.; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Parajuli S; Department of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Wisconsin, Madison, Wisconsin, USA, sparajuli@medicine.wisc.edu. |
| المصدر: | American journal of nephrology [Am J Nephrol] 2020; Vol. 51 (10), pp. 777-785. Date of Electronic Publication: 2020 Sep 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 8109361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9670 (Electronic) Linking ISSN: 02508095 NLM ISO Abbreviation: Am J Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, [1981- |
| مواضيع طبية MeSH: | Carcinoma, Renal Cell/*surgery , Graft Rejection/*epidemiology , Kidney Failure, Chronic/*surgery , Kidney Neoplasms/*surgery , Kidney Transplantation/*adverse effects, Carcinoma, Renal Cell/complications ; Case-Control Studies ; Female ; Follow-Up Studies ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival ; Humans ; Immunosuppressive Agents/therapeutic use ; Incidence ; Kidney Failure, Chronic/etiology ; Kidney Neoplasms/complications ; Kidney Transplantation/statistics & numerical data ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment/statistics & numerical data ; Risk Factors |
| مستخلص: | Background: The incidence of renal cell carcinoma (RCC) is higher in kidney transplant recipients (KTRs) compared to the general population. However, the risk factors and outcomes based on the diagnosis of RCC after kidney transplantation are limited. Methods: We analyzed risk factors for the development of RCC in KTRs transplanted at our institution between 1994 and 2016. We compared the incidence of graft failure and mortality in KTRs with RCC to matched controls using 5:1 event density sampling. Identifying the risk factors of RCC and patient and graft survival were outcomes of interest. Results: There were 4,178 KTRs performed at our institution during the study period, and 51 patients were diagnosed with RCC. Recipients were followed until graft failure or death. We did not identify commonly looked at baseline characteristics associated with the risk of RCC. Comparing KTRs with RCC to matched controls, RCC patients were younger (47.5 vs. 49.6 years, p < 0.01), received basiliximab induction more commonly (p = 0.01), had hypertension and glomerulonephritis as causes of end-stage renal disease (p = 0.01), and were more likely to be smokers (p < 0.01). RCC was significantly associated with death-censored graft failure (adjusted hazard ratio [HR]: 1.76; 95% CI: 1.02-3.03; p = 0.04) but not patient death (adjusted HR: 0.95; 95% CI: 0.50-1.83; p = 0.89). Conclusion: In our experience, RCC had a detrimental impact on graft survival among KTRs, highlighting the potential benefit of early diagnosis and optimal immunosuppression management in optimizing graft survival. (© 2020 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Graft survival; Immunosuppressed; Kidney transplant; Renal cell carcinoma |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) |
| تواريخ الأحداث: | Date Created: 20200930 Date Completed: 20210913 Latest Revision: 20210913 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000510616 |
| PMID: | 32998152 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1421-9670 |
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| DOI: | 10.1159/000510616 |