دورية أكاديمية
أعرض في EDS

Acute and early HIV infection screening among men who have sex with men, a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Acute and early HIV infection screening among men who have sex with men, a systematic review and meta-analysis.
المؤلفون: Palmer S; Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya.; International AIDS Vaccine Initiative, Amsterdam, the Netherlands., Dijkstra M; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Department of Internal Medicine, Division of Infectious Diseases, and Amsterdam Institute for Infection and Immunity (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Ket JC; Medical Library, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Wahome EW; Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya., Walimbwa J; ISHTAR MSM Health and Social Wellbeing, Nairobi, Kenya., Gichuru E; Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya., van der Elst EM; Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya., Schim van der Loeff MF; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Department of Internal Medicine, Division of Infectious Diseases, and Amsterdam Institute for Infection and Immunity (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., de Bree GJ; Department of Internal Medicine, Division of Infectious Diseases, and Amsterdam Institute for Infection and Immunity (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Sanders EJ; Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya.; Department of Global Health, and Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Nuffield Department of Medicine, University of Oxford, Headington, United Kingdom.
المصدر: Journal of the International AIDS Society [J Int AIDS Soc] 2020 Oct; Vol. 23 Suppl 6, pp. e25590.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Systematic Review
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons, Inc Country of Publication: Switzerland NLM ID: 101478566 Publication Model: Print Cited Medium: Internet ISSN: 1758-2652 (Electronic) Linking ISSN: 17582652 NLM ISO Abbreviation: J Int AIDS Soc Subsets: MEDLINE
أسماء مطبوعة: Publication: 2017- : Hoboken, NJ : John Wiley & Sons, Inc
Original Publication: [London] : BioMed Central
مواضيع طبية MeSH: Homosexuality, Male* , Mass Screening*, HIV Infections/*diagnosis, Africa South of the Sahara ; Coitus ; HIV Infections/physiopathology ; Humans ; Male ; Risk Factors ; Sexual and Gender Minorities
مستخلص: Introduction: Screening for acute and early HIV infections (AEHI) among men who have sex with men (MSM) remains uncommon in sub-Saharan Africa (SSA). Yet, undiagnosed AEHI among MSM and subsequent failure to link to care are important drivers of the HIV epidemic. We conducted a systematic review and meta-analysis of AEHI yield among MSM mobilized for AEHI testing; and assessed which risk factors and/or symptoms could increase AEHI yield in MSM.
Methods: We systematically searched four databases from their inception through May 2020 for studies reporting strategies of mobilizing MSM for testing and their AEHI yield, or risk and/or symptom scores targeting AEHI screening. AEHI yield was defined as the proportion of AEHI cases among the total number of visits. Study estimates for AEHI yield were pooled using random effects models. Predictive ability of risk and/or symptom scores was expressed as the area under the receiver operator curve (AUC).
Results: Twenty-two studies were identified and included a variety of mobilization strategies (eight studies) and risk and/or symptom scores (fourteen studies). The overall pooled AEHI yield was 6.3% (95% CI, 2.1 to 12.4; I 2  = 94.9%; five studies); yield varied between studies using targeted strategies (11.1%; 95% CI, 5.9 to 17.6; I 2  = 83.8%; three studies) versus universal testing (1.6%; 95% CI, 0.8 to 2.4; two studies). The AUC of risk and/or symptom scores ranged from 0.69 to 0.89 in development study samples, and from 0.51 to 0.88 in validation study samples. AUC was the highest for scores including symptoms, such as diarrhoea, fever and fatigue. Key risk score variables were age, number of sexual partners, condomless receptive anal intercourse, sexual intercourse with a person living with HIV, a sexually transmitted infection, and illicit drug use. No studies were identified that assessed AEHI yield among MSM in SSA and risk and/or symptom scores developed among MSM in SSA lacked validation.
Conclusions: Strategies mobilizing MSM for targeted AEHI testing resulted in substantially higher AEHI yields than universal AEHI testing. Targeted AEHI testing may be optimized using risk and/or symptom scores, especially if scores include symptoms. Studies assessing AEHI yield and validation of risk and/or symptom scores among MSM in SSA are urgently needed.
(© 2020 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.)
References: Contemp Clin Trials. 2007 Feb;28(2):105-14. (PMID: 16807131)
Int Health. 2019 Mar 1;11(2):93-100. (PMID: 30388277)
J Acquir Immune Defic Syndr. 2016 Sep 1;73(1):69-73. (PMID: 27070122)
Lancet HIV. 2015 Jul;2(7):e299-306. (PMID: 26125047)
Public Health Rep. 2015 Jan-Feb;130(1):81-6. (PMID: 25552758)
J Int AIDS Soc. 2019 Dec;22(12):e25419. (PMID: 31850686)
AIDS Behav. 2015 Aug;19(8):1460-9. (PMID: 25969182)
AIDS. 2018 Jan 28;32(3):383-392. (PMID: 29194116)
Lancet HIV. 2019 Oct;6(10):e696-e704. (PMID: 31285182)
Clin Infect Dis. 2020 Dec 3;71(9):2326-2333. (PMID: 31697383)
Retrovirology. 2013 May 29;10:56. (PMID: 23718762)
AIDS Behav. 2009 Dec;13(6):1037-45. (PMID: 19495954)
Lancet. 2011 Jul 16;378(9787):256-68. (PMID: 21684591)
N Engl J Med. 2015 Aug 27;373(9):795-807. (PMID: 26192873)
Sex Transm Dis. 2017 May;44(5):297-302. (PMID: 28407646)
Int J STD AIDS. 2017 Sep;28(10):1010-1017. (PMID: 28056724)
AIDS. 2017 Jan 14;31(2):287-293. (PMID: 27831950)
AIDS. 2008 May 31;22(9):1055-61. (PMID: 18520349)
Sci Transl Med. 2020 Mar 4;12(533):. (PMID: 32132218)
J Acquir Immune Defic Syndr. 2016 Jan 1;71(1):111-9. (PMID: 26761274)
PLoS One. 2019 Jun 27;14(6):e0218369. (PMID: 31246963)
J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):609-611. (PMID: 27851715)
AIDS. 2013 Aug 24;27(13):2163-6. (PMID: 23842136)
J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):e52-e55. (PMID: 30015794)
J Infect Dis. 2007 Apr 1;195(7):951-9. (PMID: 17330784)
Sex Transm Infect. 2013 Aug;89(5):409-14. (PMID: 23349338)
Clin Infect Dis. 2009 Jun 1;48(11):1609-16. (PMID: 19400690)
Clin Infect Dis. 2016 Feb 15;62(4):501-511. (PMID: 26508512)
JAMA. 1998 Jul 1;280(1):42-8. (PMID: 9660362)
Lancet HIV. 2019 Oct;6(10):e644-e645. (PMID: 31285180)
J Acquir Immune Defic Syndr. 2019 Apr 1;80(4):444-453. (PMID: 30550487)
Sex Transm Dis. 2017 Jan;44(1):48-56. (PMID: 27898570)
Lancet HIV. 2019 Oct;6(10):e649. (PMID: 31578951)
Stat Med. 1998 Apr 30;17(8):857-72. (PMID: 9595616)
Lancet HIV. 2019 Nov;6(11):e769-e787. (PMID: 31601542)
AIDS. 2014 Jun 1;28(9):1365-7. (PMID: 24959964)
J Infect Dis. 2008 Sep 1;198(5):687-93. (PMID: 18662132)
J Clin Epidemiol. 2016 Jan;69:245-7. (PMID: 25981519)
Arch Public Health. 2014 Nov 10;72(1):39. (PMID: 25810908)
N Engl J Med. 2016 Sep 22;375(12):1195. (PMID: 27653577)
JAMA. 2016 Feb 16;315(7):682-90. (PMID: 26881371)
PLoS One. 2009;4(3):e4997. (PMID: 19325707)
AIDS Behav. 2019 Jan;23(1):15-20. (PMID: 29951972)
Open AIDS J. 2010 Mar 05;4:76-83. (PMID: 20386719)
Clin Infect Dis. 2020 May 6;70(10):2228-2230. (PMID: 31499523)
J Acquir Immune Defic Syndr. 2012 Aug 1;60(4):421-7. (PMID: 22487585)
Sex Transm Infect. 2008 Feb;84(1):14-6. (PMID: 17971369)
PLoS One. 2011;6(12):e28792. (PMID: 22194914)
Asian Pac J Allergy Immunol. 2018 Mar;36(1):42-50. (PMID: 28364412)
Am J Epidemiol. 2018 Aug 1;187(8):1577-1585. (PMID: 29522079)
AIDS. 2015 Dec;29 Suppl 3:S221-30. (PMID: 26562811)
Lancet HIV. 2019 Oct;6(10):e688-e695. (PMID: 31285183)
J Int AIDS Soc. 2019 Jun;22(6):e25323. (PMID: 31194291)
J Int AIDS Soc. 2017 Jun 28;20(1):21708. (PMID: 28691441)
AIDS Behav. 2018 Jul;22(Suppl 1):35-44. (PMID: 29767324)
PLoS One. 2011;6(7):e21813. (PMID: 21755003)
Clin Infect Dis. 2019 Aug 1;69(4):736-737. (PMID: 30689775)
Clin Infect Dis. 2018 Jun 18;67(1):105-111. (PMID: 29293891)
AIDS Behav. 2018 Aug;22(8):2387-2412. (PMID: 29550941)
BMJ Open. 2016 Dec 8;6(12):e011458. (PMID: 27932337)
J Am Coll Health. 2013;61(4):232-41. (PMID: 23663127)
BMC Infect Dis. 2017 Jun 14;17(1):425. (PMID: 28615005)
Sex Transm Dis. 2009 Sep;36(9):547-55. (PMID: 19707108)
AIDS. 2017 Nov 28;31(18):2541-2546. (PMID: 29028659)
J Infect Dis. 2018 Sep 22;218(9):1453-1463. (PMID: 29868826)
Lancet. 2012 Jul 28;380(9839):367-77. (PMID: 22819660)
Lancet. 2009 Aug 1;374(9687):416-22. (PMID: 19616840)
Clin Infect Dis. 2015 Aug 1;61(3):468-75. (PMID: 25904374)
J Clin Microbiol. 2012 Dec;50(12):3968-76. (PMID: 23035182)
J Acquir Immune Defic Syndr. 2007 Dec 1;46(4):479-84. (PMID: 18077837)
J Int AIDS Soc. 2020 Oct;23 Suppl 6:e25590. (PMID: 33000916)
AIDS. 2014 Jun 1;28(9):1357-63. (PMID: 24556872)
N Engl J Med. 2011 May 19;364(20):1943-54. (PMID: 21591946)
PLoS One. 2015 Apr 27;10(4):e0125715. (PMID: 25915755)
J Int AIDS Soc. 2017 Jun 28;20(1):21579. (PMID: 28691435)
Sci Transl Med. 2016 Jan 6;8(320):320ra2. (PMID: 26738795)
AIDS. 2013 Oct 23;27(16):2649-54. (PMID: 23921608)
Curr Opin HIV AIDS. 2010 Jul;5(4):277-82. (PMID: 20543601)
PLoS Pathog. 2014 Dec 11;10(12):e1004543. (PMID: 25503054)
Clin Infect Dis. 2021 Jun 1;72(11):1952-1960. (PMID: 32369099)
BMJ. 2003 Sep 6;327(7414):557-60. (PMID: 12958120)
معلومات مُعتمدة: 107752 United Kingdom WT_ Wellcome Trust; R01AI124968 United States NH NIH HHS; R01 AI124968 United States AI NIAID NIH HHS; United Kingdom WT_ Wellcome Trust; 203077 United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: acute HIV infection; early HIV infection; men who have sex with men; mobilization; risk score; systematic review; targeted screening
تواريخ الأحداث: Date Created: 20201001 Date Completed: 20210413 Latest Revision: 20240331
رمز التحديث: 20240331
مُعرف محوري في PubMed: PMC7527764
DOI: 10.1002/jia2.25590
PMID: 33000916
قاعدة البيانات: MEDLINE
الوصف
تدمد:1758-2652
DOI:10.1002/jia2.25590