دورية أكاديمية
Bioactive extracts from brewer's spent grain.
| العنوان: | Bioactive extracts from brewer's spent grain. |
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| المؤلفون: | Bonifácio-Lopes T; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. mpintado@porto.ucp.pt and CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal., Vilas Boas AA; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. mpintado@porto.ucp.pt., Coscueta ER; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. mpintado@porto.ucp.pt., Costa EM; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. mpintado@porto.ucp.pt., Silva S; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. mpintado@porto.ucp.pt., Campos D; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. mpintado@porto.ucp.pt., Teixeira JA; CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal., Pintado M; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. mpintado@porto.ucp.pt. |
| المصدر: | Food & function [Food Funct] 2020 Oct 21; Vol. 11 (10), pp. 8963-8977. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Antioxidants/*isolation & purification , Edible Grain/*chemistry , Plant Extracts/*isolation & purification , Waste Products/*analysis, Antioxidants/chemistry ; Fermentation ; Phenols/chemistry ; Phenols/isolation & purification ; Plant Extracts/chemistry |
| مستخلص: | In this study, antioxidant-rich extracts from brewer's spent grain (BSG) extracted by solid-to-liquid extraction using different solvents water and ethanol and their mixtures at two ratios (80% ethanol : water (v/v) and 60% ethanol : water (v/v)) were characterized. Nutritional composition was evaluated for the extracts and for the solid residues obtained after extraction. Additionally, the extracts were analyzed for the total phenolic content and individual phenolic compounds and related biological properties including antioxidant capacity (ABTS; ORAC and DNA protection), antihypertensive capacity, antibacterial activity and antibiofilm capacity. Safety was also demonstrated through genotoxicity and cytotoxicity tests. The results obtained showed that while all the extracts exhibited high antioxidant capacity (except ethanolic extract), the highest values were obtained for the 60% ethanol : water extract. The identification of phenolic compounds using HPLC showed that catechin and vanillin were the main compounds identified with the highest concentration being obtained for 60% ethanol : water extraction. In the biological activity assays, water and hydroethanolic extracts were multifunctional (antioxidant and antihypertensive capacity, antibacterial and antibiofilm activity), and the 80% ethanol : water presented better results in some assays. All were non-genotoxic, but the cytotoxicity was dependent on the extract concentration, with complete safe application for all up to 1 mg mL-1. Therefore, this study shows the potential of a viable green solvent based and low cost extraction recovery method of bioactive compounds from brewer's spent grain. |
| التعليقات: | Erratum in: Food Funct. 2021 Nov 29;12(23):12162. (PMID: 34792072) |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Phenols) 0 (Plant Extracts) 0 (Waste Products) |
| تواريخ الأحداث: | Date Created: 20201001 Date Completed: 20210709 Latest Revision: 20211118 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/d0fo01426e |
| PMID: | 33001088 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
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| DOI: | 10.1039/d0fo01426e |