دورية أكاديمية
أعرض في EDS

Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion: development and characterization.

التفاصيل البيبلوغرافية
العنوان: Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion: development and characterization.
المؤلفون: Halder S; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh., Ahmed F; Department of Pharmacy, BRAC University, Mohakhali, Dhaka, 1212, Bangladesh., Shuma ML; Department of Pharmacy, Stamford University Bangladesh, Siddeswari, Dhaka, 1217, Bangladesh., Azad MAK; Department of Pharmacy, BRAC University, Mohakhali, Dhaka, 1212, Bangladesh., Kabir ER; Department of Pharmacy, BRAC University, Mohakhali, Dhaka, 1212, Bangladesh.
المصدر: Heliyon [Heliyon] 2020 Sep 21; Vol. 6 (9), pp. e05026. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Purpose: The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques.
Methods: SRSD-CAR containing different ratios of polymers were prepared and physicochemically characterized. Dissolution study was carried out in both sink and supersaturated conditions to identify the possible enhancement in dissolution behavior.
Results: Based on the solubility study, Kolliphor® P188 and Eudragit® RSPO (50:25, % w/w) ratio exhibited the highest solubility among the samples and was chosen as the optimal composition of SRSD-CAR for further characterization. The crystallinity assessments of the optimized formulation indicated amorphization of CAR in the formulation, bring about improved solubility of CAR. The infrared spectroscopic study revealed minor transitions; demonstrating the absence of significant interactions between drug and carrier. Furthermore, the SRSD-CAR exhibited immediate formation of nano particles when dispersed in water. Dissolution study revealed significant improvement in dissolution behavior, with a release of CAR in a gradual manner compared to crystalline CAR. From the dissolution kinetics analysis, the Korsmeyer Peppas model fit the best and diffusion was predominant in release of CAR. The drug release pattern showed insignificant differences between the SRSD-CAR formulations prepared by rotary vacuum drying and freeze drying.
Conclusion: From these experimental findings, SRSD approach might be a favorable dosage option for CAR, offering improved biopharmaceutical properties.
(© 2020 The Author(s).)
References: Eur J Pharm Sci. 2018 Nov 1;124:319-327. (PMID: 30194980)
Int J Pharm. 2011 Mar 15;406(1-2):41-8. (PMID: 21219991)
Mol Pharm. 2006 Nov-Dec;3(6):631-43. (PMID: 17140251)
Expert Opin Drug Deliv. 2007 Jul;4(4):403-16. (PMID: 17683253)
Eur J Pharm Sci. 2013 Jul 16;49(4):453-60. (PMID: 23707470)
Drug Dev Ind Pharm. 2008 Jun;34(6):588-94. (PMID: 18568908)
Pharm Dev Technol. 2016;21(4):463-74. (PMID: 25777532)
J Pharm Biomed Anal. 2014 Aug 5;96:10-20. (PMID: 24705456)
Eur J Pharm Biopharm. 2008 Oct;70(2):493-9. (PMID: 18577451)
AAPS PharmSciTech. 2016 Apr;17(2):418-26. (PMID: 26202065)
Int J Pharm. 2016 Jan 30;497(1-2):3-11. (PMID: 26608620)
Drug Deliv. 2017 Nov;24(1):1731-1739. (PMID: 29124978)
Pharm Dev Technol. 2009;14(4):373-9. (PMID: 19552551)
AAPS J. 2010 Sep;12(3):263-71. (PMID: 20373062)
Drug Des Devel Ther. 2019 Apr 17;13:1241-1249. (PMID: 31118565)
Colloids Surf B Biointerfaces. 2012 Jun 15;95:1-9. (PMID: 22463845)
Eur J Pharm Sci. 2014 Oct 1;62:16-22. (PMID: 24836392)
Arch Pharm Res. 2011 Jan;34(1):51-7. (PMID: 21468915)
J Pharm Sci. 1999 Oct;88(10):1058-66. (PMID: 10514356)
AAPS PharmSciTech. 2018 Jan;19(1):358-370. (PMID: 28741140)
Eur J Clin Pharmacol. 1990;38 Suppl 2:S108-11. (PMID: 1974498)
Int J Pharm. 2015 Dec 30;496(1):33-41. (PMID: 25863118)
Curr Drug Deliv. 2014;11(2):155-71. (PMID: 23859356)
Pharm Res. 1995 Mar;12(3):413-20. (PMID: 7617530)
Eur J Pharm Biopharm. 2007 Mar;65(3):259-69. (PMID: 17196803)
Int J Pharm. 2011 Nov 25;420(1):1-10. (PMID: 21884771)
Curr Drug Metab. 2018;19(13):1111-1118. (PMID: 29956619)
Eur J Pharm Biopharm. 2008 May;69(1):388-95. (PMID: 18164928)
Colloids Surf B Biointerfaces. 2016 Apr 1;140:403-411. (PMID: 26780253)
Acta Pharm Sin B. 2015 Sep;5(5):442-53. (PMID: 26579474)
Eur J Pharm Biopharm. 2010 Feb;74(2):275-80. (PMID: 19969078)
Profiles Drug Subst Excip Relat Methodol. 2013;38:113-57. (PMID: 23668404)
Drug Dev Ind Pharm. 2003 Sep;29(8):909-24. (PMID: 14570312)
Biopharm Drug Dispos. 2018 Apr;39(4):232-242. (PMID: 29607517)
J Pharm Sci. 2014 Nov;103(11):3511-3523. (PMID: 25196860)
Saudi Pharm J. 2014 Apr;22(2):141-7. (PMID: 24648826)
Iran J Basic Med Sci. 2019 May;22(5):547-556. (PMID: 31217936)
Curr Pharm Des. 2016;22(32):4942-4958. (PMID: 27464728)
Drug Dev Ind Pharm. 2018 Nov;44(11):1838-1844. (PMID: 30059249)
Pharm Res. 2016 Jan;33(1):102-9. (PMID: 26264511)
فهرسة مساهمة: Keywords: Biopharmaceutical; Carvedilol; Drug delivery; Drug development; Drying; Pharmaceutical engineering; Pharmaceutical science; Solubility; Sustained release solid dispersion
تواريخ الأحداث: Date Created: 20201002 Latest Revision: 20240802
رمز التحديث: 20240802
مُعرف محوري في PubMed: PMC7511744
DOI: 10.1016/j.heliyon.2020.e05026
PMID: 33005811
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2020.e05026