دورية أكاديمية
Effects of N-Pep-12 dietary supplementation on neurorecovery after ischemic stroke.
| العنوان: | Effects of N-Pep-12 dietary supplementation on neurorecovery after ischemic stroke. |
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| المؤلفون: | Balea M; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Birle C; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Costin C; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Marton J; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Muresanu IA; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Jemna N; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Popa LL; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Slavoaca D; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Rosu OV; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Stan A; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Vacaras V; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Strilciuc S; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania., Muresanu DF; RoNeuro Institute for Neurological Research and Diagnostic, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania. dafinm@ssnn.ro.; Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 37 Mircea Eliade Street, 4004878, Cluj-Napoca, Romania. dafinm@ssnn.ro. |
| المصدر: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 May; Vol. 42 (5), pp. 2031-2037. Date of Electronic Publication: 2020 Oct 02. |
| نوع المنشور: | Clinical Trial, Phase IV; Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milano, Italy : Springer-Verlag Italia, c2000- |
| مواضيع طبية MeSH: | Brain Ischemia*/complications , Brain Ischemia*/drug therapy , Ischemic Stroke* , Stroke*/complications , Stroke*/drug therapy, Aged ; Amino Acids ; Dietary Supplements ; Humans ; Middle Aged |
| مستخلص: | Background: The aim of the study was to evaluate the effects of N-Pep-12 dietary supplementation on neurorecovery of middle-aged and older adults with cognitive impairment after ischemic stroke, using neuropsychological outcome scales. Methods: This was a pilot randomized-controlled, phase IV, academic clinical trial that aimed to assess the effect and the safety of a single daily dose of oral 90 mg of N-Pep-12 for 90 days in supporting neurorecovery, as compared with a control group, performed on middle-aged and older adults after supratentorial ischemic stroke. Results: Study group differences in baseline changes at day 90 for Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS) - Anxiety subscale, Color Trails 1 and Symbol Search (number incorrect) were statistically significant (Mann-Whitney U test). For MoCA at day 90, a borderline 'intermediate effect' in favour of N-PEP-12 was observed (d Conclusion: This exploratory clinical trial indicates a signal for the benefit of dietary supplementation with N-Pep-12 for the enhancement of neurorecovery after supratentorial ischemic stroke. |
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| فهرسة مساهمة: | Keywords: Ischemic stroke; N-PEP-12; Neurorecovery |
| المشرفين على المادة: | 0 (Amino Acids) 0 (N-PEP-12) |
| تواريخ الأحداث: | Date Created: 20201002 Date Completed: 20210514 Latest Revision: 20220531 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10072-020-04707-9 |
| PMID: | 33006057 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1590-3478 |
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| DOI: | 10.1007/s10072-020-04707-9 |