دورية أكاديمية
أعرض في EDS

Prospective application of phthalocyanines in the photodynamic therapy against microorganisms and tumor cells: A mini-review.

التفاصيل البيبلوغرافية
العنوان: Prospective application of phthalocyanines in the photodynamic therapy against microorganisms and tumor cells: A mini-review.
المؤلفون: Santos KLM; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, PB, Brazil., Barros RM; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, PB, Brazil., da Silva Lima DP; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, PB, Brazil., Nunes AMA; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, PB, Brazil., Sato MR; Department of Drugs and Medicines, Faculdade de Ciências Farmacêuticas, UNESP - Univ. Estadual Paulista, Campus Araraquara, Araraquara, SP, Brazil., Faccio R; Área Física & Centro NanoMat, DETEMA, Facultad de Química-Universidad de la República (UdelaR), Montevideo, CP, 11800, Uruguay., de Lima Damasceno BPG; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, PB, Brazil. Electronic address: bolivarpgld@servidor.uepb.edu.br., Oshiro-Junior JA; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, PB, Brazil. Electronic address: joao.oshiro@pq.cnpq.br.
المصدر: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2020 Dec; Vol. 32, pp. 102032. Date of Electronic Publication: 2020 Oct 02.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101226123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1597 (Electronic) Linking ISSN: 15721000 NLM ISO Abbreviation: Photodiagnosis Photodyn Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; Boston : Elsevier, c2004-
مواضيع طبية MeSH: Indoles*/pharmacology , Indoles*/therapeutic use , Photochemotherapy*/methods , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/therapeutic use, Isoindoles ; Prospective Studies
مستخلص: Phthalocyanines are second-generation photosensitizers with photophysical and photochemical properties improved, in comparison to the first-generation. Also, these have shown to be phototoxic against several types of microorganisms and tumor cells. However, challenges such as low solubility in the physiological environment make its single administration unfeasible. Therefore, this review discusses a unique combination of phthalocyanine-loaded in drug delivery carriers for photodynamic therapy in different pathologies' treatment, including nanoemulsion, liposomes, and lipid nanoparticles in an attempt to overcome low solubility drawback. Furthermore, the latest advances to elucidating its mechanisms of action are shown. Subsequently, the manuscript was divided into ten different types of phthalocyanines for medical applications, with a description of their definitions and applications, summarizing the latest preclinical results founded in recent literature.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Drug delivery nanocarriers; Nanocarriers; New therapy; Photosensitizer; Therapeutic modalities
المشرفين على المادة: 0 (Indoles)
0 (Isoindoles)
0 (Photosensitizing Agents)
V5PUF4VLGY (phthalocyanine)
تواريخ الأحداث: Date Created: 20201005 Date Completed: 20210510 Latest Revision: 20211204
رمز التحديث: 20221213
DOI: 10.1016/j.pdpdt.2020.102032
PMID: 33017659
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1597
DOI:10.1016/j.pdpdt.2020.102032