دورية أكاديمية
أعرض في EDS

Sex Does Not Influence Visual Outcomes After Blast-Mediated Traumatic Brain Injury but IL-1 Pathway Mutations Confer Partial Rescue.

التفاصيل البيبلوغرافية
العنوان: Sex Does Not Influence Visual Outcomes After Blast-Mediated Traumatic Brain Injury but IL-1 Pathway Mutations Confer Partial Rescue.
المؤلفون: Evans LP; Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States.; Medical Scientist Training Program, University of Iowa, Iowa City, Iowa, United States., Boehme N; Iowa City VA Health Care System Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, United States., Wu S; Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States., Burghardt EL; Medical Scientist Training Program, University of Iowa, Iowa City, Iowa, United States.; Department of Biostatistics, University of Iowa, Iowa City, Iowa, United States., Akurathi A; Iowa City VA Health Care System Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, United States., Todd BP; Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States.; Medical Scientist Training Program, University of Iowa, Iowa City, Iowa, United States., Newell EA; Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States., Ferguson PJ; Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States., Mahajan VB; Omics Laboratory, Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States., Dutca LM; Iowa City VA Health Care System Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, United States.; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States., Harper MM; Iowa City VA Health Care System Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, United States.; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States., Bassuk AG; Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States.
المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Oct 01; Vol. 61 (12), pp. 7.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: Brookline Ma : Association For Research In Vision And Ophthalmology (Arvo)
Original Publication: St. Louis, Mosby.
مواضيع طبية MeSH: Blast Injuries/*physiopathology , Brain Injuries, Traumatic/*physiopathology , Gene Expression Regulation/*physiology , Interleukin-1/*genetics , Retinal Ganglion Cells/*physiology , Visual Acuity/*physiology, Animals ; Blast Injuries/metabolism ; Brain Injuries, Traumatic/metabolism ; Cell Survival/physiology ; Electroretinography ; Female ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Sex Factors ; Tomography, Optical Coherence ; Transcription Factor Brn-3A/metabolism
مستخلص: Purpose: In a mouse model of blast-mediated traumatic brain injury (bTBI), interleukin-1 (IL-1)-pathway components were tested as potential therapeutic targets for bTBI-mediated retinal ganglion cell (RGC) dysfunction. Sex was also evaluated as a variable for RGC outcomes post-bTBI.
Methods: Male and female mice with null mutations in genes encoding IL-1α, IL-1β, or IL-1RI were compared to C57BL/6J wild-type (WT) mice after exposure to three 20-psi blast waves given at an interblast interval of 1 hour or to mice receiving sham injury. To determine if genetic blockade of IL-1α, IL-1β, or IL-1RI could prevent damage to RGCs, the function and structure of these cells were evaluated by pattern electroretinogram and optical coherence tomography, respectively, 5 weeks following blast or sham exposure. RGC survival was also quantitatively assessed via immunohistochemical staining of BRN3A at the completion of the study.
Results: Our results showed that male and female WT mice had a similar response to blast-induced retinal injury. Generally, constitutive deletion of IL-1α, IL-1β, or IL-1RI did not provide full protection from the effects of bTBI on visual outcomes; however, injured WT mice had significantly worse visual outcomes compared to the injured genetic knockout mice.
Conclusions: Sex does not affect RGC outcomes after bTBI. The genetic studies suggest that deletion of these IL-1 pathway components confers some protection, but global deletion from birth did not result in a complete rescue.
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معلومات مُعتمدة: P30 EY026877 United States EY NEI NIH HHS; R01 EY024665 United States EY NEI NIH HHS; R01 NS098590 United States NS NINDS NIH HHS; R01 EY024698 United States EY NEI NIH HHS; R01 EY025225 United States EY NEI NIH HHS; R01 AR059703 United States AR NIAMS NIH HHS; I01 RX000952 United States RX RRD VA; IK2 RX002003 United States RX RRD VA; R21 AG050437 United States AG NIA NIH HHS; F30 EY031245 United States EY NEI NIH HHS; T32 GM007337 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Interleukin-1)
0 (Pou4f1 protein, mouse)
0 (Transcription Factor Brn-3A)
تواريخ الأحداث: Date Created: 20201008 Date Completed: 20210507 Latest Revision: 20210507
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7582458
DOI: 10.1167/iovs.61.12.7
PMID: 33030508
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-5783
DOI:10.1167/iovs.61.12.7