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Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria.

التفاصيل البيبلوغرافية
العنوان: Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria.
المؤلفون: Dieng MM; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE., Diawara A; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE., Manikandan V; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE., Tamim El Jarkass H; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Sermé SS; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sombié S; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Barry A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Coulibaly SA; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Diarra A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Drou N; Bioinformatics Core, New York University Abu Dhabi, Abu Dhabi, UAE., Arnoux M; Core Technology Platforms, New York University Abu Dhabi, Abu Dhabi, UAE., Yousif A; Bioinformatics Core, New York University Abu Dhabi, Abu Dhabi, UAE., Tiono AB; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sirima SB; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Soulama I; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Idaghdour Y; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE. youssef.idaghdour@nyu.edu.
المصدر: Nature communications [Nat Commun] 2020 Oct 09; Vol. 11 (1), pp. 5093. Date of Electronic Publication: 2020 Oct 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Immune Evasion/*genetics , Malaria, Falciparum/*genetics , Malaria, Falciparum/*immunology , MicroRNAs/*genetics , Plasmodium falciparum/*pathogenicity, Burkina Faso ; Child ; Child, Preschool ; Gene Expression Regulation ; Genome, Human ; Humans ; Longitudinal Studies ; Parasitemia/genetics ; Parasitemia/immunology ; Plasmodium falciparum/immunology ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Messenger/genetics ; Whole Genome Sequencing
مستخلص: The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria. We report a strong signature of miRNA expression differentiation associated with P. falciparum infection (127 out of 320 miRNAs, B-H FDR 5%) and parasitemia (72 miRNAs, B-H FDR 5%). Integrative miRNA-mRNA analysis implicates several infection-responsive miRNAs (e.g., miR-16-5p, miR-15a-5p and miR-181c-5p) promoting lymphocyte cell death. miRNA cis-eQTL analysis using whole-genome sequencing data identified 1,376 genetic variants associated with the expression of 34 miRNAs (B-H FDR 5%). We report a protective effect of rs114136945 minor allele on parasitemia mediated through miR-598-3p expression. These results highlight the impact of post-transcriptional regulation, immune cell death processes and host genetic regulatory control in malaria.
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المشرفين على المادة: 0 (MIRN-598 microRNA, human)
0 (MicroRNAs)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (RNA, Messenger)
تواريخ الأحداث: Date Created: 20201010 Date Completed: 20201102 Latest Revision: 20231112
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7547729
DOI: 10.1038/s41467-020-18915-6
PMID: 33037226
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-020-18915-6