دورية أكاديمية
Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria.
العنوان: | Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria. |
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المؤلفون: | Dieng MM; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE., Diawara A; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE., Manikandan V; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE., Tamim El Jarkass H; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Sermé SS; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sombié S; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Barry A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Coulibaly SA; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Diarra A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Drou N; Bioinformatics Core, New York University Abu Dhabi, Abu Dhabi, UAE., Arnoux M; Core Technology Platforms, New York University Abu Dhabi, Abu Dhabi, UAE., Yousif A; Bioinformatics Core, New York University Abu Dhabi, Abu Dhabi, UAE., Tiono AB; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sirima SB; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Soulama I; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Idaghdour Y; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, UAE. youssef.idaghdour@nyu.edu. |
المصدر: | Nature communications [Nat Commun] 2020 Oct 09; Vol. 11 (1), pp. 5093. Date of Electronic Publication: 2020 Oct 09. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
مواضيع طبية MeSH: | Immune Evasion/*genetics , Malaria, Falciparum/*genetics , Malaria, Falciparum/*immunology , MicroRNAs/*genetics , Plasmodium falciparum/*pathogenicity, Burkina Faso ; Child ; Child, Preschool ; Gene Expression Regulation ; Genome, Human ; Humans ; Longitudinal Studies ; Parasitemia/genetics ; Parasitemia/immunology ; Plasmodium falciparum/immunology ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Messenger/genetics ; Whole Genome Sequencing |
مستخلص: | The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria. We report a strong signature of miRNA expression differentiation associated with P. falciparum infection (127 out of 320 miRNAs, B-H FDR 5%) and parasitemia (72 miRNAs, B-H FDR 5%). Integrative miRNA-mRNA analysis implicates several infection-responsive miRNAs (e.g., miR-16-5p, miR-15a-5p and miR-181c-5p) promoting lymphocyte cell death. miRNA cis-eQTL analysis using whole-genome sequencing data identified 1,376 genetic variants associated with the expression of 34 miRNAs (B-H FDR 5%). We report a protective effect of rs114136945 minor allele on parasitemia mediated through miR-598-3p expression. These results highlight the impact of post-transcriptional regulation, immune cell death processes and host genetic regulatory control in malaria. |
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المشرفين على المادة: | 0 (MIRN-598 microRNA, human) 0 (MicroRNAs) 0 (Proto-Oncogene Proteins c-bcl-2) 0 (RNA, Messenger) |
تواريخ الأحداث: | Date Created: 20201010 Date Completed: 20201102 Latest Revision: 20231112 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7547729 |
DOI: | 10.1038/s41467-020-18915-6 |
PMID: | 33037226 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2041-1723 |
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DOI: | 10.1038/s41467-020-18915-6 |