دورية أكاديمية
Unraveling the susceptibility of paracoccidioidomycosis: Insights towards the pathogen-immune interplay and immunogenetics.
| العنوان: | Unraveling the susceptibility of paracoccidioidomycosis: Insights towards the pathogen-immune interplay and immunogenetics. |
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| المؤلفون: | Cezar-Dos-Santos F; Laboratory of Applied Immunology, Department of Pathological Sciences, State University of Londrina, Londrina, PR, Brazil; Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, State University of Londrina, Londrina, PR, Brazil. Electronic address: fernando.bmed@gmail.com., Assolini JP; Laboratory of Applied Immunology, Department of Pathological Sciences, State University of Londrina, Londrina, PR, Brazil., Okuyama NCM; Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, State University of Londrina, Londrina, PR, Brazil., Viana KF; Interdisciplinary Center for Life Sciences and Nature, Federal University of Latin American Integration, Foz do Iguaçu, PR, Brazil., de Oliveira KB; Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, State University of Londrina, Londrina, PR, Brazil., Itano EN; Laboratory of Applied Immunology, Department of Pathological Sciences, State University of Londrina, Londrina, PR, Brazil. |
| المصدر: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2020 Dec; Vol. 86, pp. 104586. Date of Electronic Publication: 2020 Oct 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Disease Susceptibility*/immunology, Host-Pathogen Interactions/*immunology , Paracoccidioidomycosis/*etiology, Biomarkers ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Host-Pathogen Interactions/genetics ; Humans ; Paracoccidioides/immunology ; Paracoccidioidomycosis/diagnosis ; Paracoccidioidomycosis/metabolism |
| مستخلص: | Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis caused by Paracoccidioides spp. This disease comprises three clinical forms: symptomatic acute and chronic forms (PCM disease) and PCM infection, a latent form without clinical symptoms. PCM disease differs markedly according to severity, clinical manifestations, and host immune response. Fungal virulence factors and adhesion molecules are determinants for entry, latency, immune escape and invasion, and dissemination in the host. Neutrophils and macrophages play a paramount role in first-line defense against the fungus through the recognition of antigens by pattern recognition receptors (PRRs), activating their microbicidal machinery. Furthermore, the clinical outcome of the PCM is strongly associated with the variability of cytokines and immunoglobulins produced by T and B cells. While the mechanisms that mediate susceptibility or resistance to infection are dictated by the immune system, some genetic factors may alter gene expression and its final products and, hence, modulate how the organism responds to infection and injury. This review outlines the main findings relative to this topic, addressing the complexity of the immune response triggered by Paracoccidioides spp. infection from preclinical investigations to studies in humans. Here, we focus on mechanisms of fungal pathogenesis, the patterns of innate and adaptive immunity, and the genetic and molecular basis related to immune response and susceptibility to the development of the PCM and its clinical forms. Immunogenetic features such as HLA system, cytokines/cytokines receptors genes and other immune-related genes, and miRNAs are likewise discussed. Finally, we point out the occurrence of PCM in patients with primary immunodeficiencies and call attention to the research gaps and challenges faced by the PCM field. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Candidate genes; HLA; Immune response; PIDs; Paracoccidioidomycosis; microRNA |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20201011 Date Completed: 20211108 Latest Revision: 20211108 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.meegid.2020.104586 |
| PMID: | 33039601 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1567-7257 |
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| DOI: | 10.1016/j.meegid.2020.104586 |