دورية أكاديمية
Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers.
| العنوان: | Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers. |
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| المؤلفون: | Marlinge M; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Vairo D; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Bertaud A; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Vernet C; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Chefrour M; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Bruzzese L; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Chaptal MC; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Mottola G; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Boussuges A; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; ERRSO: Institute of Biomedical Research of the French Army (IRBA), Toulon, France., Risso JJ; ERRSO: Institute of Biomedical Research of the French Army (IRBA), Toulon, France., Blot-Chabaud M; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Coulange M; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; UFR STAPS, Toulon University, Toulon, France., Guieu R; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France. guieu.regis@orange.fr.; Laboratory of Biochemistry, Timone Hospital, Marseille, France. guieu.regis@orange.fr., Joulia F; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; UFR STAPS, Toulon University, Toulon, France. |
| المصدر: | European journal of applied physiology [Eur J Appl Physiol] 2021 Jan; Vol. 121 (1), pp. 279-285. Date of Electronic Publication: 2020 Oct 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 100954790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-6327 (Electronic) Linking ISSN: 14396319 NLM ISO Abbreviation: Eur J Appl Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag, c2000- |
| مواضيع طبية MeSH: | Adaptation, Physiological* , Breath Holding*, Adenosine/*blood , Altitude Sickness/*metabolism , Diving/*physiology , Equilibrative Nucleoside Transporter 1/*metabolism, Adenosine Deaminase/metabolism ; Adult ; Altitude Sickness/physiopathology ; Blood Pressure ; Female ; Heart Rate ; Humans ; Male ; Middle Aged |
| مستخلص: | Purpose: Long static or intense dynamic apnoea-like high-altitude exposure is inducing hypoxia. Adenosine is known to participate to the adaptive response to hypoxia leading to the control of heart rate, blood pressure and vasodilation. Extracellular adenosine level is controlled through the equilibrative nucleoside transporter 1 (ENT-1) and the enzyme adenosine deaminase (ADA). The aim of this study was to determine the control of adenosine blood level (ABL) via ENT-1 and ADA during apnoea-induced hypoxia in elite freedivers was similar to high-altitude adaptation. Methods: Ten freediver champions and ten controls were studied. Biological (e.g. ENT-1, ADA, ABL, PaO Results: In freedivers, ABL was higher than in control participants in basal condition and increased more in response to apnoea. Also, freedivers showed an ADA increased in response to apnoea. Finally, ENT-1 level and function were reduced for the free divers. Conclusion: Our results suggest in freedivers the presence of an adaptive mechanism similar to the one observed in human exposed to chronic hypoxia induced by high-altitude environment. |
| References: | Andersson J, Schagatay E (1998) Arterial oxygen desaturation during apnea in humans. Undersea Hyperb Med 25:21–25. (PMID: 9566083) Attias J, Bieles J, Carvil P, Laing C, Lewis F, Jaka O, O’Brien K, Ruchaya P (2017) Altitude exposure and increased heart rate: the role of the parasympathetic nervous system. J Physiol (Lond) 595:4589–4590. Bain AR, Drvis I, Dujic Z, MacLeod DB, Ainslie PN (2018) Physiology of static breath holding in elite apneists. Exp Physiol 103:635–651. (PMID: 29512224) Baldwin SA, Beal PR, Yao SYM, King AE, Cass CE, Young JD (2004) The equilibrative nucleoside transporter family, SLC29. Pflugers Arch 447:735–743. (PMID: 12838422) Bärtsch P, Gibbs JSR (2007) Effect of altitude on the heart and the lungs. Circulation 116:2191–2202. (PMID: 17984389) Bonello L, Laine M, Kipson N, Mancini J, Helal O, Fromonot J, Gariboldi V, Condo J, Thuny F, Frere C, Camoin-Jau L, Paganelli F, Dignat-George F, Guieu R (2014) Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome. J Am Coll Cardiol 63:872–877. (PMID: 24291273) Boussuges A, Gavarry O, Bessereau J, Coulange M, Bourc’his M, Rossi P (2014) Glossopharyngeal insufflation and breath-hold diving: the more, the worse? Wilderness Environ Med 25:466–471. (PMID: 25443752) Bruzzese L, Fromonot J, By Y, Durand-Gorde J-M, Condo J, Kipson N, Guieu R, Fenouillet E, Ruf J (2014) NF-κB enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A(2A) receptors. Cell Signal 26:1060–1067. (PMID: 24486403) Bruzzese L, Rostain J-C, Née L, Condo J, Mottola G, Adjriou N, Mercier L, Berge-Lefranc J-L, Fromonot J, Kipson N, Lucciano M, Durand-Gorde J-M, Jammes Y, Guieu R, Ruf J, Fenouillet E (2015) Effect of hyperoxic and hyperbaric conditions on the adenosinergic pathway and CD26 expression in rat. J Appl Physiol 119:140–147. (PMID: 25997945) Bulmer AC, Coombes JS, Sharman JE, Stewart IB (2008) Effects of maximal static apnea on antioxidant defenses in trained free divers. Med Sci Sports Exerc 40:1307–1313. (PMID: 18580412) Casanello P, Torres A, Sanhueza F, González M, Farías M, Gallardo V, Pastor-Anglada M, San Martín R, Sobrevia L (2005) Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium. Circ Res 97:16–24. (PMID: 15933265) Coney AM, Marshall JM (1998) Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. J Physiol (Lond) 509(Pt 2):507–518. Eichhorn L, Erdfelder F, Kessler F, Dolscheid-Pommerich RC, Zur B, Hoffmann U, Ellerkmann RE, Meyer R (2017) Influence of apnea-induced hypoxia on catecholamine release and cardiovascular dynamics. Int J Sports Med 38:85–91. (PMID: 27454133) Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Schönfeld C, Löffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP (2005) HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med 202:1493–1505. (PMID: 163308132213326) Eltzschig HK, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, Odegard KC, Laussen PC, Thompson LF, Colgan SP (2006) Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood 108:1602–1610. (PMID: 166702671895500) Fagoni N, Sivieri A, Antonutto G, Moia C, Taboni A, Bringard A, Ferretti G (2015) Cardiovascular responses to dry resting apnoeas in elite divers while breathing pure oxygen. Respir Physiol Neurobiol 219:1–8. (PMID: 26253502) Feoktistov I, Ryzhov S, Zhong H, Goldstein AE, Matafonov A, Zeng D, Biaggioni I (2004) Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype. Hypertension 44:649–654. (PMID: 15452028) Ferretti G, Costa M (2003) Diversity in and adaptation to breath-hold diving in humans. Comp Biochem Physiol Part A Mol Integr Physiol 136:205–213. Görlach A (2005) Control of adenosine transport by hypoxia. Circ Res 97:1–3. (PMID: 16002753) Iwamoto T, Umemura S, Toya Y, Uchibori T, Kogi K, Takagi N, Ishii M (1994) Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun 199:905–910. (PMID: 8135838) Joulia F, Steinberg JG, Faucher M, Jamin T, Ulmer C, Kipson N, Jammes Y (2003) Breath-hold training of humans reduces oxidative stress and blood acidosis after static and dynamic apnea. Respir Physiol Neurobiol 137:19–27. (PMID: 12871674) Joulia F, Coulange M, Lemaitre F, Costalat G, Franceschi F, Gariboldi V, Nee L, Fromonot J, Bruzzese L, Gravier G, Kipson N, Jammes Y, Boussuges A, Brignole M, Deharo JC, Guieu R (2013) Plasma adenosine release is associated with bradycardia and transient loss of consciousness during experimental breath-hold diving. Int J Cardiol 168:e138–e141. (PMID: 24016542) Joulia F, Coulange M, Desplantes A, Barberon B, Kipson N, Gerolami V, Jammes Y, Kerbaul F, Née L, Fromonot J, Bruzzese L, Michelet P, Boussuges A, Brignole M, Deharo J-C, Guieu R (2014) Purinergic profile of fainting divers is different from patients with vasovagal syncope. Int J Cardiol 174:741–743. (PMID: 24798778) Keil VC, Eichhorn L, Mutsaerts HJMM, Träber F, Block W, Mädler B, van de Ven K, Siero JCW, MacIntosh BJ, Petr J, Fimmers R, Schild HH, Hattingen E (2018) Cerebrovascular reactivity during prolonged breath-hold in experienced freedivers. AJNR Am J Neuroradiol 39:1839–1847. (PMID: 302372997410726) Liu H et al (2016) Beneficial role of erythrocyte adenosine A2B receptor-mediated AMPK activation in high altitude hypoxia. Circulation 134:405–421. (PMID: 274820036168195) Maille B et al (2019) Adenosine plasma level in patients with paroxysmal or persistent atrial fibrillation and normal heart during ablation procedure and/or cardioversion. Purinergic Signal 15:45. (PMID: 30535950) Marlinge M, Vairo D, Marolda V, Bruzzese L, Adjriou N, Guiol C, Kipson N, Bonardel A, Gastaldi M, Kerbaul F, Michelet P, Deharo JC, Mottola G, Mace P, Chefrour M, Guieu R (2017) Rapid measurement of adenosine concentration in human blood using fixed potential amperometry: comparison with mass spectrometry and high-performance liquid chromatography. J Anal Bioanal Technol 8:4. Moore LG (2017) Measuring high-altitude adaptation. J Appl Physiol 123:1371–1385. (PMID: 288601675792094) Morelli MS, Greco A, Valenza G, Giannoni A, Emdin M, Scilingo EP, Vanello N (2018) Analysis of generic coupling between EEG activity and PETCO Morote-Garcia JC, Rosenberger P, Kuhlicke J, Eltzschig HK (2008) HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak. Blood 111:5571–5580. (PMID: 18309031) Paganelli F, Resseguier N, Marlinge M, Laine M, Malergue F, Kipson N, Armangau P, Pezzoli N, Kerbaul F, Bonello L, Mottola G, Fenouillet E, Guieu R, Ruf J (2018) Specific pharmacological profile of A2A adenosine receptor predicts reduced fractional flow reserve in patients with suspected coronary artery disease. J Am Heart Assoc 7:e008290. (PMID: 296541946015402) Plagemann PGW (1986) Transport and metabolism of adenosine in human erthrocytes: effect of transport inhibitors and regulation by phosphate. J Cell Physiol 128:491–500. (PMID: 3488996) Ruf J, Paganelli F, Bonello L, Kipson N, Mottola G, Fromonot J, Condo J, Boussuges A, Bruzzese L, Kerbaul F, Jammes Y, Gariboldi V, Franceschi F, Fenouillet E, Guieu R (2016) Spare adenosine A2a receptors are associated with positive exercise stress test in coronary artery disease. Mol Med 22:530–536. (PMID: 274633345082304) Ruf J, Vairo D, Paganelli F, Guieu R (2019) Extracellular vesicles with ubiquitinated adenosine A2A receptor in plasma of patients with coronary artery disease. J Cell Mol Med 23:6805–6811. (PMID: 314449946787504) Sacramento JF, Melo BF, Conde SV (2018) Adenosine mediates hypercapnic response in the rat carotid body via A2A and A2B receptors. Adv Exp Med Biol 1071:89–93. (PMID: 30357738) Sampol J, Dussol B, Fenouillet E, Capo C, Mege JL, Halimi G, Bechis G, Brunet P, Rochat H, Berland Y, Guieu R (2001) High adenosine and deoxyadenosine concentrations in mononuclear cells of hemodialyzed patients. J Am Soc Nephrol 12:1721–1728. (PMID: 11461945) Shah N, Bye K, Marshall A, Woods DR, O’Hara J, Barlow M, Rimmer J, Boos CJ (2020) The effects of apnea training, using voluntary breath holds, on high altitude acclimation: breathe-high altitude study. High Alt Med Biol 21:152–159. (PMID: 32267783) Song A et al (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8:14108. (PMID: 281699865309698) Taboni A, Vinetti G, Bruseghini P, Camelio S, D’Elia M, Moia C, Ferretti G, Fagoni N (2018) Cardiovascular responses to dry apnoeas at exercise in air and in pure oxygen. Respir Physiol Neurobiol 255:17–21. (PMID: 29733980) Taboni A, Fagoni N, Moia C, Vinetti G, Ferretti G (2019) Gas exchange and cardiovascular responses during breath-holding in divers. Respir Physiol Neurobiol 267:27–34. (PMID: 31201868) Vinetti G, Lopomo NF, Taboni A, Fagoni N, Ferretti G (2020) The current use of wearable sensors to enhance safety and performance in breath-hold diving: a systematic review. Diving Hyperb Med 50:54–65. (PMID: 32187619) |
| فهرسة مساهمة: | Keywords: Adenosine; Adenosine deaminase; Apnoea; ENT-1; Hypoxia |
| المشرفين على المادة: | 0 (Equilibrative Nucleoside Transporter 1) 0 (SLC29A1 protein, human) EC 3.5.4.4 (ADA protein, human) EC 3.5.4.4 (Adenosine Deaminase) K72T3FS567 (Adenosine) |
| تواريخ الأحداث: | Date Created: 20201014 Date Completed: 20210928 Latest Revision: 20210928 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s00421-020-04523-1 |
| PMID: | 33052430 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1439-6327 |
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| DOI: | 10.1007/s00421-020-04523-1 |