دورية أكاديمية
Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers.
العنوان: | Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers. |
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المؤلفون: | Marlinge M; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Vairo D; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Bertaud A; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Vernet C; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Chefrour M; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Bruzzese L; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Chaptal MC; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Mottola G; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; Laboratory of Biochemistry, Timone Hospital, Marseille, France., Boussuges A; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; ERRSO: Institute of Biomedical Research of the French Army (IRBA), Toulon, France., Risso JJ; ERRSO: Institute of Biomedical Research of the French Army (IRBA), Toulon, France., Blot-Chabaud M; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France., Coulange M; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; UFR STAPS, Toulon University, Toulon, France., Guieu R; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France. guieu.regis@orange.fr.; Laboratory of Biochemistry, Timone Hospital, Marseille, France. guieu.regis@orange.fr., Joulia F; C2VN, INSERM 1263, INRAE 1260, Faculty of Pharmacy, Aix Marseille University, Bvd J Moulin 13005, Marseille, France.; UFR STAPS, Toulon University, Toulon, France. |
المصدر: | European journal of applied physiology [Eur J Appl Physiol] 2021 Jan; Vol. 121 (1), pp. 279-285. Date of Electronic Publication: 2020 Oct 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 100954790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-6327 (Electronic) Linking ISSN: 14396319 NLM ISO Abbreviation: Eur J Appl Physiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag, c2000- |
مواضيع طبية MeSH: | Adaptation, Physiological* , Breath Holding*, Adenosine/*blood , Altitude Sickness/*metabolism , Diving/*physiology , Equilibrative Nucleoside Transporter 1/*metabolism, Adenosine Deaminase/metabolism ; Adult ; Altitude Sickness/physiopathology ; Blood Pressure ; Female ; Heart Rate ; Humans ; Male ; Middle Aged |
مستخلص: | Purpose: Long static or intense dynamic apnoea-like high-altitude exposure is inducing hypoxia. Adenosine is known to participate to the adaptive response to hypoxia leading to the control of heart rate, blood pressure and vasodilation. Extracellular adenosine level is controlled through the equilibrative nucleoside transporter 1 (ENT-1) and the enzyme adenosine deaminase (ADA). The aim of this study was to determine the control of adenosine blood level (ABL) via ENT-1 and ADA during apnoea-induced hypoxia in elite freedivers was similar to high-altitude adaptation. Methods: Ten freediver champions and ten controls were studied. Biological (e.g. ENT-1, ADA, ABL, PaO Results: In freedivers, ABL was higher than in control participants in basal condition and increased more in response to apnoea. Also, freedivers showed an ADA increased in response to apnoea. Finally, ENT-1 level and function were reduced for the free divers. Conclusion: Our results suggest in freedivers the presence of an adaptive mechanism similar to the one observed in human exposed to chronic hypoxia induced by high-altitude environment. |
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فهرسة مساهمة: | Keywords: Adenosine; Adenosine deaminase; Apnoea; ENT-1; Hypoxia |
المشرفين على المادة: | 0 (Equilibrative Nucleoside Transporter 1) 0 (SLC29A1 protein, human) EC 3.5.4.4 (ADA protein, human) EC 3.5.4.4 (Adenosine Deaminase) K72T3FS567 (Adenosine) |
تواريخ الأحداث: | Date Created: 20201014 Date Completed: 20210928 Latest Revision: 20210928 |
رمز التحديث: | 20221213 |
DOI: | 10.1007/s00421-020-04523-1 |
PMID: | 33052430 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1439-6327 |
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DOI: | 10.1007/s00421-020-04523-1 |