دورية أكاديمية
أعرض في EDS

RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner.

التفاصيل البيبلوغرافية
العنوان: RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner.
المؤلفون: Liang YY; Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China., Deng XB; Department of Internal Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China., Lin XT; Department of Internal Oncology, The First Affiliated Hospital of Hainan Medical University, Haiko, China., Jiang LL; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China., Huang XT; Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China., Mo ZW; Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China., Yuan YW; Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China., Teh MT; Cancer Research Institute, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China. m.t.teh@qmul.ac.uk.; Centre for Oral Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, England, United Kingdom. m.t.teh@qmul.ac.uk.; China-British Joint Molecular Head and Neck Cancer Research Laboratory, Affiliated Stomatological Hospital of Guizhou Medical University, Guizhou, China. m.t.teh@qmul.ac.uk.
المصدر: Cell death & disease [Cell Death Dis] 2020 Oct 14; Vol. 11 (10), pp. 855. Date of Electronic Publication: 2020 Oct 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Pub. Group
مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Nasopharyngeal Carcinoma/*metabolism , Nasopharyngeal Neoplasms/*metabolism , Proto-Oncogene Proteins c-sis/*metabolism , Transcription Factors/*metabolism , Tumor Suppressor Proteins/*metabolism, Actin Cytoskeleton/metabolism ; Animals ; Biomarkers, Tumor/biosynthesis ; Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Genes, Tumor Suppressor ; Heterografts ; Humans ; Mice ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/pathology ; Phenotype ; Proto-Oncogene Proteins c-sis/antagonists & inhibitors ; Signal Transduction ; Transfection ; Tumor Suppressor Proteins/biosynthesis ; Tumor Suppressor Proteins/genetics ; YAP-Signaling Proteins
مستخلص: Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or underlying mechanism of RASSF1A on the malignant phenotype. In the present study, we observed that RASSF1A expression inhibited the malignant phenotypes of NPC cells. Stable silencing of RASSF1A in NPC cell lines induced self-renewal properties and tumorigenicity in vivo/in vitro and the acquisition of an invasive phenotype in vitro. Mechanistically, RASSF1A inactivated Yes-associated Protein 1 (YAP1), a transcriptional coactivator, through actin remodeling, which further contributed to Platelet Derived Growth Factor Subunit B (PDGFB) transcription inhibition. Treatment with ectopic PDGFB partially increased the malignancy of NPC cells with transient knockdown of YAP1. Collectively, these findings suggest that RASSF1A inhibits malignant phenotypes by repressing PDGFB expression in a YAP1-dependent manner. PDGFB may serve as a potential interest of therapeutic regulators in patients with metastatic NPC.
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المشرفين على المادة: 0 (Adaptor Proteins, Signal Transducing)
0 (Biomarkers, Tumor)
0 (Proto-Oncogene Proteins c-sis)
0 (RASSF1 protein, human)
0 (Transcription Factors)
0 (Tumor Suppressor Proteins)
0 (YAP-Signaling Proteins)
0 (YAP1 protein, human)
تواريخ الأحداث: Date Created: 20201015 Date Completed: 20210513 Latest Revision: 20211204
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7560678
DOI: 10.1038/s41419-020-03054-z
PMID: 33057010
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-4889
DOI:10.1038/s41419-020-03054-z