دورية أكاديمية
أعرض في EDS

Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production.

التفاصيل البيبلوغرافية
العنوان: Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production.
المؤلفون: Turrero García M; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Baizabal JM; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Tran DN; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Peixoto R; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Wang W; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Xie Y; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Adam MA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., English LA; Summer Honors Undergraduate Research Program, Harvard Medical School, Boston, MA 02115, USA., Reid CM; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Brito SI; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Booker MA; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Harwell CC; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA corey_harwell@hms.harvard.edu.
المصدر: Development (Cambridge, England) [Development] 2020 Nov 16; Vol. 147 (22). Date of Electronic Publication: 2020 Nov 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge Eng : Company Of Biologists Limited
Original Publication: [Cambridge] : Company of Biologists, [c1987-
مواضيع طبية MeSH: Cerebral Cortex/*metabolism , DNA-Binding Proteins/*metabolism , GABAergic Neurons/*metabolism , Interneurons/*metabolism , Neural Stem Cells/*metabolism , Transcription Factors/*metabolism, Animals ; Cerebral Cortex/cytology ; DNA-Binding Proteins/genetics ; GABAergic Neurons/cytology ; Interneurons/cytology ; Mice ; Neural Stem Cells/cytology ; Transcription Factors/genetics
مستخلص: The mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, whereas inhibitory interneurons are generated in its ventral portion. The transcriptional regulator PRDM16 is expressed by radial glia, neural progenitors present in both regions; however, its mechanisms of action are still not fully understood. It is unclear whether PRDM16 plays a similar role in neurogenesis in both dorsal and ventral progenitor lineages and, if so, whether it regulates common or unique networks of genes. Here, we show that Prdm16 expression in mouse medial ganglionic eminence (MGE) progenitors is required for maintaining their proliferative capacity and for the production of proper numbers of forebrain GABAergic interneurons. PRDM16 binds to cis-regulatory elements and represses the expression of region-specific neuronal differentiation genes, thereby controlling the timing of neuronal maturation. PRDM16 regulates convergent developmental gene expression programs in the cortex and MGE, which utilize both common and region-specific sets of genes to control the proliferative capacity of neural progenitors, ensuring the generation of correct numbers of cortical neurons.
Competing Interests: Competing interestsThe authors declare no competing or financial interests.
(© 2020. Published by The Company of Biologists Ltd.)
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معلومات مُعتمدة: R01 MH119156 United States MH NIMH NIH HHS; R01 NS102228 United States NS NINDS NIH HHS; R56 MH119156 United States MH NIMH NIH HHS; T32 MH020017 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: CNS development; Cortical interneurons; Medial ganglionic eminence; Neural progenitors; Prdm16
المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (Prdm16 protein, mouse)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20201016 Date Completed: 20210119 Latest Revision: 20220815
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7687860
DOI: 10.1242/dev.187526
PMID: 33060132
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-9129
DOI:10.1242/dev.187526