دورية أكاديمية
أعرض في EDS

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

التفاصيل البيبلوغرافية
العنوان: Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
المؤلفون: Gordon DE; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Hiatt J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Bouhaddou M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Rezelj VV; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France., Ulferts S; Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany., Braberg H; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Jureka AS; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Obernier K; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Guo JZ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Batra J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Kaake RM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Weckstein AR; Aetion, Inc., New York, NY 10001, USA., Owens TW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Gupta M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pourmal S; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Titus EW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Cakir M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Soucheray M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., McGregor M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. 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David Gladstone Institutes, San Francisco, CA 94158, USA., O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Tummino TA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Zhang Z; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Foussard H; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. 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QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Jura N; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA., Kortemme T; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.; The University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, University of California, San Francisco, CA 94158, USA., Manglik A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Southworth DR; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Stroud RM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Alessi DR; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Davies P; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Ideker T; Department of Medicine, University of California, San Diego, CA 92093, USA.; Department to Bioengineering, University of California, San Diego, CA 92093, USA., Abate C; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'ALDO MORO', Via Orabona, 4 70125, Bari, Italy., Jouvenet N; Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany.; Département de Virologie, CNRS UMR 3569, Institut Pasteur, Paris 75015, France., Kochs G; Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany., Shoichet B; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Ott M; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Palmarini M; MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK., Shokat KM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rassen JA; Aetion, Inc., New York, NY 10001, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Grosse R; Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, 79104 Freiburg, Germany., Rosenberg OS; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Verba KA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Basler CF; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Vignuzzi M; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Peden AA; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Beltrao P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Krogan NJ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
مؤلفون مشاركون: QCRG Structural Biology Consortium, Zoonomia Consortium
المصدر: Science (New York, N.Y.) [Science] 2020 Dec 04; Vol. 370 (6521). Date of Electronic Publication: 2020 Oct 15.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة: Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH: Host Microbial Interactions* , Protein Interaction Maps*, COVID-19/*metabolism , Coronavirus Nucleocapsid Proteins/*metabolism , Mitochondrial Membrane Transport Proteins/*metabolism , Severe acute respiratory syndrome-related coronavirus/*metabolism , SARS-CoV-2/*metabolism , Severe Acute Respiratory Syndrome/*metabolism, Conserved Sequence ; Coronavirus Nucleocapsid Proteins/genetics ; Cryoelectron Microscopy ; Humans ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Precursor Protein Import Complex Proteins ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Conformation
مستخلص: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.
(Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
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معلومات مُعتمدة: INV-006099 United States GATES Bill & Melinda Gates Foundation; T32 AI060537 United States AI NIAID NIH HHS; T32 GM007618 United States GM NIGMS NIH HHS; R01 AI122747 United States AI NIAID NIH HHS; F32 CA239333 United States CA NCI NIH HHS; R01 AI128214 United States AI NIAID NIH HHS; R35 GM122481 United States GM NIGMS NIH HHS; P01 AI063302 United States AI NIAID NIH HHS; P50 AI150476 United States AI NIAID NIH HHS; MC_UU_12016/2 United Kingdom MRC_ Medical Research Council; BB/J014443/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; R01 GM024485 United States GM NIGMS NIH HHS; F30 AI143401 United States AI NIAID NIH HHS; R01 AI120694 United States AI NIAID NIH HHS; T32 GM008284 United States GM NIGMS NIH HHS; MC_PC_19026 United Kingdom MRC_ Medical Research Council; R01 HG008742 United States HG NHGRI NIH HHS; United States HHMI Howard Hughes Medical Institute; U19 AI135990 United States AI NIAID NIH HHS; F32 GM137463 United States GM NIGMS NIH HHS; 201366/Z/16/Z United Kingdom WT_ Wellcome Trust; R01 NS089713 United States NS NINDS NIH HHS; R35 GM118099 United States GM NIGMS NIH HHS; R01 HG009979 United States HG NHGRI NIH HHS; MR/V03541X/1 United Kingdom MRC_ Medical Research Council; MC_UU_00018/1 United Kingdom MRC_ Medical Research Council; P01 AI120943 United States AI NIAID NIH HHS; U19 AI135972 United States AI NIAID NIH HHS; MC_UU_12014/2 United Kingdom MRC_ Medical Research Council; K99 GM138753 United States GM NIGMS NIH HHS; F32 CA239336 United States CA NCI NIH HHS; R01 AI143292 United States AI NIAID NIH HHS
فهرسة مساهمة: Investigator: TW Owens; M Gupta; S Pourmal; EW Titus; CM Azumaya; C Billesbølle; AF Brilot; MG Campbell; A Diallo; MS Dickinson; D Diwanji; N Herrera; N Hoppe; HT Kratochvil; Y Liu; GE Merz; M Moritz; HC Nguyen; C Nowotny; C Puchades; AN Rizo; U Schulze-Gahmen; AM Smith; M Sun; ID Young; J Zhao; D Asarnow; J Biel; A Bowen; JR Braxton; J Chen; CM Chio; US Chio; I Deshpande; L Doan; B Faust; S Flores; M Jin; K Kim; VL Lam; F Li; J Li; YL Li; Y Li; X Liu; M Lo; KE Lopez; AA Melo; FR Moss; P Nguyen; J Paulino; KI Pawar; JK Peters; TH Pospiech; M Safari; S Sangwan; K Schaefer; PV Thomas; AC Thwin; R Trenker; E Tse; TKM Tsui; F Wang; N Whitis; Z Yu; K Zhang; Y Zhang; F Zhou; D Trinidad; DA Agard; Y Cheng; JS Fraser; A Frost; N Jura; T Kortemme; A Manglik; DR Southworth; RM Stroud; OS Rosenberg; KA Verba; J Damas; GM Hughes; KC Keough; CA Painter; NS Persky; M Corbo; B Kirilenko; M Hiller; KP Koepfli; I Kaplow; M Wirthlin; AR Pfenning; H Zhao; DP Genereux; R Swofford; A Lind; KS Pollard; OA Ryderq; MT Nweeia; J Meadows; M Dong; O Wallerman; V Marinescu; K Lindblad-Toh; DA Ray; S Power; EC Teeling; G Chauhan; SX Li; EK Karlsson; HA Lewin
المشرفين على المادة: 0 (Coronavirus Nucleocapsid Proteins)
0 (Mitochondrial Membrane Transport Proteins)
0 (Mitochondrial Precursor Protein Import Complex Proteins)
0 (Phosphoproteins)
0 (TOMM70 protein, human)
0 (nucleocapsid phosphoprotein, SARS-CoV-2)
تواريخ الأحداث: Date Created: 20201016 Date Completed: 20201228 Latest Revision: 20240401
رمز التحديث: 20240401
مُعرف محوري في PubMed: PMC7808408
DOI: 10.1126/science.abe9403
PMID: 33060197
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9203
DOI:10.1126/science.abe9403