دورية أكاديمية
Proteinuric and nonproteinuric chronic kidney disease among patients with sickle cell anaemia (HbSS) attending a tertiary hospital in north-eastern Nigeria.
| العنوان: | Proteinuric and nonproteinuric chronic kidney disease among patients with sickle cell anaemia (HbSS) attending a tertiary hospital in north-eastern Nigeria. |
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| المؤلفون: | Sulaiman MM; Nephrology Unit, Department of Medicine, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria; Department of Medicine, Faculty of Clinical Sciences, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Ladu AI; Department of Haematology and Blood Transfusion, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria; Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Abba AM; Department of Haematology and Blood Transfusion, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria; Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Bukar AA; Department of Haematology and Blood Transfusion, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria; Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria. Electronic address: draabukar@unimaid.edu.ng. |
| المصدر: | Hematology/oncology and stem cell therapy [Hematol Oncol Stem Cell Ther] 2021 Sep; Vol. 14 (3), pp. 214-217. Date of Electronic Publication: 2020 Oct 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: King Faisal Cancer Center, King Faisal Specialist Hospital and Research Centre Country of Publication: Saudi Arabia NLM ID: 101468532 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0646 (Electronic) Linking ISSN: 25890646 NLM ISO Abbreviation: Hematol Oncol Stem Cell Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Riyadh : King Faisal Cancer Center, King Faisal Specialist Hospital and Research Centre |
| مواضيع طبية MeSH: | Anemia, Sickle Cell*/epidemiology , Anemia, Sickle Cell*/etiology , Anemia, Sickle Cell*/physiopathology , Anemia, Sickle Cell*/therapy , Proteinuria*/epidemiology , Proteinuria*/etiology , Proteinuria*/physiopathology , Proteinuria*/therapy , Renal Insufficiency, Chronic*/epidemiology , Renal Insufficiency, Chronic*/etiology , Renal Insufficiency, Chronic*/physiopathology , Renal Insufficiency, Chronic*/therapy , Tertiary Care Centers*, Adolescent ; Adult ; Cross-Sectional Studies ; Female ; Humans ; Male ; Nigeria/epidemiology |
| مستخلص: | Objective/background: Individuals with sickle cell anaemia (SCA) may manifest various forms of renal abnormalities. Proteinuria is an early marker of renal dysfunction and a strong risk factor for chronic kidney disease (CKD) progression in both patients with SCA and non-SCA population. Currently, the degree of attention given to proteinuric CKD far exceeds that of nonproteinuric CKD, and risk factors that might trigger a progressive decline of the glomerular filtration rate (GFR) in the absence of proteinuria have not been well evaluated in SCA. The aim of this study was to compare the clinical and laboratory parameters among SCA patients with proteinuric and nonproteinuric CKD. Methods: This was a cross-sectional study conducted at the University of Maiduguri Teaching Hospital in north-eastern Nigeria between January 2013 and April 2018. Clinical variables including age of diagnosis of SCA, frequency of vaso-occlusive crises, number of hospitalizations per annum and transfusion therapy were collected. Laboratory data including haematological profile and renal function test were obtained from routine blood sampling. Results: A total of 257 patients with SCA (HbSS) were enrolled during the study period of which 42 had proteinuric CKD, and 48 had nonproteinuric CKD. The two groups were matched for the number of hospital admission (p = .063) and blood transfusion per year (p = .450), frequency of painful crisis (p = .210), systolic blood pressure (p = .084) and diastolic blood pressure (p = .400). In the proteinuric CKD group, the mean serum creatinine was higher (332.17 µmol/L, p = .001) and the estimated GFR was lower (31.88 mL/min, p = .046). The serum alkaline phosphatase was higher in the nonproteinuric CKD group (81.81 IU/L, p = .012). Conclusion: Nonproteinuric CKD was more frequent than proteinuric CKD in our study population; however, the proteinuric group presented with more advanced disease. Competing Interests: Declaration of Competing Interest The authors have declared no conflict of interest (Copyright © 2020 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chronic kidney disease; Proteinuria; Sickle cell anaemia |
| تواريخ الأحداث: | Date Created: 20201016 Date Completed: 20210916 Latest Revision: 20210916 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.hemonc.2020.09.003 |
| PMID: | 33065100 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2589-0646 |
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| DOI: | 10.1016/j.hemonc.2020.09.003 |