دورية أكاديمية
Dual PET Imaging of an H3K27M-Mutant Glioma With 18F-GE-180 and 18F-FET PET.
| العنوان: | Dual PET Imaging of an H3K27M-Mutant Glioma With 18F-GE-180 and 18F-FET PET. |
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| المؤلفون: | Vettermann FJ, Unterrainer M, Ruf V; Neuropathology., Fleischmann DF; Radiation Oncology, University Hospital, LMU Munich, Munich., Rupprecht R; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg., Forbrig R; Institute of Neuroradiology., Herms J; Neuropathology., Tonn JC, Belka C, Bartenstein P, Niyazi M, Albert NL |
| المصدر: | Clinical nuclear medicine [Clin Nucl Med] 2020 Dec; Vol. 45 (12), pp. 992-993. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, Lippincott. |
| مواضيع طبية MeSH: | Carbazoles* , Mutation* , Positron-Emission Tomography*, Brain Neoplasms/*diagnostic imaging , Glioma/*diagnostic imaging , Histones/*genetics , Tyrosine/*analogs & derivatives, Adult ; Biological Transport ; Biopsy ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Glioma/genetics ; Glioma/pathology ; Humans ; Male |
| مستخلص: | A 25-year-old man presented with headache and intracranial pressure symptoms. On MRI, an intracranial lesion was detected in the right thalamus with exophytic growth into the third ventricle and inhomogeneous contrast enhancement without necrosis. Dual amino acid (F-FET) and TSPO (F-GE-180) PET imaging showed high tumor-to-background ratios in both scans and a short time-to-peak in F-FET uptake dynamics. Biopsy revealed a diffuse midline glioma, H3K27M-mutant (WHO grade IV), a novel entity in the 2016 WHO classification with poor clinical outcome. Our case shows that the highly aggressive features of this tumor entity can be visualized in vivo by both PET modalities. |
| References: | Unterrainer M, Fleischmann DF, Diekmann C, et al. Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study. Eur J Nucl Med Mol Imaging. 2019;46:580–590. Galldiks N, Langen KJ, Pope WB. From the clinician’s point of view—what is the status quo of positron emission tomography in patients with brain tumors?Neuro Oncol. 2015;17:1434–1444. Kunz M, Albert NL, Unterrainer M, et al. Dynamic 18F-FET PET is a powerful imaging biomarker in gadolinium-negative gliomas. Neuro Oncol. 2019;21:274–284. Albert NL, Unterrainer M, Fleischmann DF, et al. TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma. Eur J Nucl Med Mol Imaging. 2017;44:2230–2238. Sturm D, Witt H, Hovestadt V, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012;22:425–437. Neumann JE, Dorostkar MM, Korshunov A, et al. Distinct histomorphology in molecular subgroups of glioblastomas in young patients. J Neuropathol Exp Neurol. 2016;75:408–414. Vettermann FJ, Neumann JE, Suchorska B, et al. K27M midline gliomas display malignant progression by imaging and histology. Neuropathol Appl Neurobiol. 2017;43:458–462. Chen H, Hu W, He H, et al. Noninvasive assessment of H3 K27M mutational status in diffuse midline gliomas by using apparent diffusion coefficient measurements. Eur J Radiol. 2019;114:152–159. Law I, Albert NL, Arbizu J, et al. Joint EANM/EANO/RANO practice guidelines/SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0. Eur J Nucl Med Mol Imaging. 2019;46:540–557. Vlodavsky E, Soustiel JF. Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival. J Neurooncol. 2007;81:1–7. Su Z, Roncaroli F, Durrenberger PF, et al. The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study. J Nucl Med. 2015;56:512–517. |
| المشرفين على المادة: | 0 (Carbazoles) 0 (GE-180) 0 (Histones) 1326R5J1IA ((18F)fluoroethyltyrosine) 42HK56048U (Tyrosine) |
| تواريخ الأحداث: | Date Created: 20201016 Date Completed: 20201204 Latest Revision: 20210204 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/RLU.0000000000003331 |
| PMID: | 33065624 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-0229 |
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| DOI: | 10.1097/RLU.0000000000003331 |