دورية أكاديمية
أعرض في EDS

Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses.

التفاصيل البيبلوغرافية
العنوان: Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses.
المؤلفون: Poplawsky AJ; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15203, United States., Iordanova B; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15203, United States., Vazquez AL; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15203, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15203, United States., Kim SG; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 440-330, Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 440-330, Korea., Fukuda M; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15203, United States. Electronic address: mif5@pitt.edu.
المصدر: NeuroImage [Neuroimage] 2021 Jan 15; Vol. 225, pp. 117457. Date of Electronic Publication: 2020 Oct 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Orlando, FL : Academic Press, c1992-
مواضيع طبية MeSH: Brain/*diagnostic imaging , Cerebrovascular Circulation/*physiology , GABAergic Neurons/*physiology , Neurovascular Coupling/*physiology, Amino Acid Transport System X-AG/antagonists & inhibitors ; Animals ; Brain/physiology ; Cerebrovascular Circulation/drug effects ; Electric Stimulation ; Functional Neuroimaging ; GABA-B Receptor Agonists ; GABAergic Neurons/drug effects ; Laser-Doppler Flowmetry ; Magnetic Resonance Imaging ; Neural Inhibition ; Neurovascular Coupling/drug effects ; Nitric Oxide Synthase/antagonists & inhibitors ; Olfactory Bulb/cytology ; Rats ; Receptors, AMPA/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, Vasoactive Intestinal Peptide/antagonists & inhibitors
مستخلص: Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia. Here, the neuronal origins of these hemodynamic responses were investigated by fMRI or local field potential and blood flow measurements during topical application of pharmacological agents when GABAergic granule cells in the rat olfactory bulb were synaptically targeted. First, to examine if postsynaptic activation of these inhibitory neurons was required for neurovascular coupling, we applied an NMDA receptor antagonist during cerebral blood volume-weighted fMRI acquisition and found that responses below the drug application site (up to ~1.5 mm) significantly decreased within ~30 min. Similarly, large decreases in granule cell postsynaptic activities and blood flow responses were observed when AMPA or NMDA receptor antagonists were applied. Second, inhibition of nitric oxide synthase preferentially decreased the initial, fast component of the blood flow response, while inhibitors of astrocyte-specific glutamate transporters and vasoactive intestinal peptide receptors did not decrease blood flow responses. Third, inhibition of GABA release with a presynaptic GABA B receptor agonist caused less reduction of neuronal and blood flow responses compared to the postsynaptic glutamate receptor antagonists. In conclusion, local hyperemia by synaptically-evoked inhibitory neurons was primarily driven by their postsynaptic activities, possibly through NMDA receptor-dependent calcium signaling that was not wholly dependent on nitric oxide.
Competing Interests: Declaration of Competing Interest The authors declare they have no competing financial interests.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: RF1 NS116450 United States NS NINDS NIH HHS; R01 NS094404 United States NS NINDS NIH HHS; R01 EB003324 United States EB NIBIB NIH HHS; R01 NS117515 United States NS NINDS NIH HHS; R01 NS110564 United States NS NINDS NIH HHS; R01 NS119410 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: BOLD; CBF; CBV; GABAergic neurons; Neurovascular coupling
المشرفين على المادة: 0 (Amino Acid Transport System X-AG)
0 (GABA-B Receptor Agonists)
0 (Receptors, AMPA)
0 (Receptors, N-Methyl-D-Aspartate)
0 (Receptors, Vasoactive Intestinal Peptide)
EC 1.14.13.39 (Nitric Oxide Synthase)
تواريخ الأحداث: Date Created: 20201018 Date Completed: 20210310 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC7818351
DOI: 10.1016/j.neuroimage.2020.117457
PMID: 33069862
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9572
DOI:10.1016/j.neuroimage.2020.117457