دورية أكاديمية
Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study.
| العنوان: | Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study. |
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| المؤلفون: | Cobra SB; Federal District Base Hospital Institute and School of Medicine, University of Brasília , Brasília, Brazil., Rodrigues MP; School of Medicine, University of Brasília , Brasília, Brazil., de Melo FX; Department of Pulmonology, University Hospital of Brasília , Brasília, Brazil., Ferreira NMC; Department of Pulmonology, University Hospital of Brasília , Brasília, Brazil., Passini VV; Department of Pulmonology, University Hospital of Brasília , Brasília, Brazil., Amado VM; School of Medicine, University of Brasília , Brasília, Brazil., Melo-Silva CA; Department of Pulmonology, University Hospital of Brasília , Brasília, Brazil. |
| المصدر: | Expert review of respiratory medicine [Expert Rev Respir Med] 2021 Feb; Vol. 15 (2), pp. 249-256. Date of Electronic Publication: 2020 Oct 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278196 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-6356 (Electronic) Linking ISSN: 17476348 NLM ISO Abbreviation: Expert Rev Respir Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Future Drugs, c2007- |
| مواضيع طبية MeSH: | Idiopathic Pulmonary Fibrosis*/diagnostic imaging , Idiopathic Pulmonary Fibrosis*/therapy , Ventricular Dysfunction, Right*/diagnostic imaging , Ventricular Dysfunction, Right*/etiology, Cross-Sectional Studies ; Humans ; Prospective Studies ; Ventricular Function, Right |
| مستخلص: | Background: Little is known about right ventricular dysfunction in non-advanced idiopathic pulmonary fibrosis (IPF) patients without hypoxemia at rest. We evaluated it at rest and during exercise. Research Design and Methods: 123 IPF patients were evaluated, and 27 met all the following criteria: Gender-Age-Physiology Index score ≤5, modified Medical Research Council dyspnea score ≤3, peripheral oxygen saturation ≥92% at rest, and no history of oxygen therapy. They were submitted to two-dimensional speckle-tracking echocardiography at rest and during cardiopulmonary exercise to analyze right ventricular global longitudinal strain. Results: Abnormal speckle-tracking echocardiography findings were identified in 10/27 patients (37%), indicating right ventricular (RV) dysfunction. No patients had abnormalities observed in conventional echocardiographic parameters. Significant differences in mPAP were observed between patients with RV dysfunction and those without dysfunction (at rest: 26.0 ± 4.8 vs. 19.1 ± 4.2 mmHg, p = 0.001; during exercise: 51.3 ± 6.4 vs. 36.9 ± 14.7 mmHg, p = 0.002). Conclusions: RV dysfunction was detected in 37% of non-advanced IPF patients and early recognition was only possible using speckle-tracking echocardiography. Special attention should be given to these patients as RV dysfunction is suggestive of worse prognosis. These patients could benefit from new specific drugs or even oxygen therapy for transitory hypoxia. |
| فهرسة مساهمة: | Keywords: Echocardiography; idiopathic pulmonary fibrosis; pulmonary hypertension; right ventricle; speckle-tracking strain |
| تواريخ الأحداث: | Date Created: 20201019 Date Completed: 20211021 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/17476348.2021.1834856 |
| PMID: | 33070645 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1747-6356 |
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| DOI: | 10.1080/17476348.2021.1834856 |