دورية أكاديمية
Gastroprotective and cicatrizing activity of the Ziziphus joazeiro Mart. leaf hydroalcoholic extract.
| العنوان: | Gastroprotective and cicatrizing activity of the Ziziphus joazeiro Mart. leaf hydroalcoholic extract. |
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| المؤلفون: | Brito SMO; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., Martins AOBPB; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., de Oliveira MRC; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., Vidal CS; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., de Lacerda Neto LJ; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., Ramos AGB; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., da Cruz LP; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., Nascimento EA; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., da Costa JGM; Research and Natural Products Laboratory, Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil., Coutinho HDM; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, Crato, Ceara, Brazil., Quintans-Junior LJ; Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, Brazil., de Menezes IRA; Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceara, Brazil. irwinalencar@yahoo.com.br; irwin.alencar@urca.br. |
| المصدر: | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society [J Physiol Pharmacol] 2020 Jun; Vol. 71 (3). Date of Electronic Publication: 2020 Oct 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Polish Physiological Society Country of Publication: Poland NLM ID: 9114501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1899-1505 (Electronic) Linking ISSN: 08675910 NLM ISO Abbreviation: J Physiol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Krakow : Polish Physiological Society Original Publication: [Kraków] : The Society, [1991- |
| مواضيع طبية MeSH: | Plant Leaves*/chemistry , Ziziphus*/chemistry, Anti-Ulcer Agents/*pharmacology , Gastric Mucosa/*drug effects , Plant Extracts/*pharmacology , Stomach Ulcer/*prevention & control , Wound Healing/*drug effects, Animals ; Anti-Ulcer Agents/isolation & purification ; Disease Models, Animal ; Ethanol ; Female ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Indomethacin ; Male ; Mice ; Plant Extracts/isolation & purification ; Stomach Ulcer/chemically induced ; Stomach Ulcer/pathology ; Time Factors |
| مستخلص: | Ziziphus joazeiro Mart., popularly known as 'juazeiro', is a species used in popular medicine for the treatment of bronchitis, gastric ulcers, skin wounds, and in the manufacture of cosmetic and food products. The objective of this study is to evaluate the gastroprotective and cicatrizing activity of the Z. joazeiro Mart. leaf hydroalcoholic extract (EHFZJ). The acute pre-clinical toxicity was determined by the single administration of the EHFZJ (2000 mg/kg/p.o.) and by assessing clinical signs of toxicity, according to established criteria by Malone, or mortality. Gastroprotective activity was identified through classical models of acute gastric lesions induced by indomethacin, absolute and acidified ethanol (100, 200 and 400 mg/kg/per os) and the physical barrier mechanism (400 mg/kg/per os or intraperitoneally). The cicatrizing activity of the EHFZJ was investigated by measuring the speed of wound closure and the percentage of contraction. The acute pre-clinical toxicity of EHFZJ showed no signs of toxicity and mortality. The EHFZJ demonstrated a gastroprotective effect at the 400 mg/kg dose in the classical models of acute gastric injury induced by indomethacin, absolute and acidified ethanol. The EHFZJ administration (orally) demonstrated significant inhibition, suggesting a possible physical barrier mechanism exists. The EHFZJ showed no significant differences in terms of percentage of contraction or the speed of wound closure during the observation times (0, 3, 7, 11 and 14 days). The results obtained in this study provide evidence of a potential gastroprotective activity for the Ziziphus joazeiro Mart. Leaf hydroalcoholic extract. |
| المشرفين على المادة: | 0 (Anti-Ulcer Agents) 0 (Plant Extracts) 3K9958V90M (Ethanol) XXE1CET956 (Indomethacin) |
| تواريخ الأحداث: | Date Created: 20201020 Date Completed: 20210714 Latest Revision: 20210714 |
| رمز التحديث: | 20231215 |
| DOI: | 10.26402/jpp.2020.3.14 |
| PMID: | 33077695 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1899-1505 |
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| DOI: | 10.26402/jpp.2020.3.14 |