دورية أكاديمية
أعرض في EDS

Balanopreputial sac and urine microbiota in patients with male genital lichen sclerosus.

التفاصيل البيبلوغرافية
العنوان: Balanopreputial sac and urine microbiota in patients with male genital lichen sclerosus.
المؤلفون: Watchorn RE; Department of Dermatology, University College Hospital, London, UK., van den Munckhof EHA; DDL Diagnostic Laboratory, Rijswijk, Netherlands., Quint KD; Department of Dermatology, Leiden University Medical Center, Leiden, Netherlands., Eliahoo J; Statistical Advisory Service, Imperial College London, London, UK., de Koning MNC; DDL Diagnostic Laboratory, Rijswijk, Netherlands., Quint WGV; DDL Diagnostic Laboratory, Rijswijk, Netherlands., Bunker CB; Department of Dermatology, University College Hospital, London, UK.
المصدر: International journal of dermatology [Int J Dermatol] 2021 Feb; Vol. 60 (2), pp. 201-207. Date of Electronic Publication: 2020 Oct 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 0243704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-4632 (Electronic) Linking ISSN: 00119059 NLM ISO Abbreviation: Int J Dermatol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell Science
Original Publication: Philadelphia, Lippincott.
مواضيع طبية MeSH: Lichen Sclerosus et Atrophicus* , Microbiota*, Case-Control Studies ; Foreskin ; Humans ; Male ; Prospective Studies ; RNA, Ribosomal, 16S/genetics
مستخلص: Background: Male genital lichen sclerosus (MGLSc) is a chronic inflammatory scarring dermatosis associated with penile carcinoma. The prepuce is pivotal in its etiology. Other proposed etiological factors are the subject of dispute and include occluded urinary exposure, autoimmunity, immunodysregulation, and infectious agents.
Objective: To determine whether the bacterial microbiota of the balanopreputial sac and urine are associated with MGLSc.
Subjects and Methods: Twenty uncircumcised patients with MGLSc and 20 healthy uncircumcised males were enrolled in a prospective case-control study. Balanopreputial swabs and urine specimens were subjected to 16S rRNA gene amplicon sequencing.
Results: Microbiota analysis indicated differences between the groups. In the balanopreputial sac, the median relative abundance of Finegoldia spp. was lower (9% [range 0-60%]) in MGLSc patients than in controls (28% [range 0-62%]). Conversely, the median relative abundance of Fusobacterium spp. was higher in MGLSc patients (4% [range 0-41%]) than in controls (0% [range 0-28%]). In the urine, the median relative abundance of Finegoldia spp. was comparable between groups, whereas that of Fusobacterium spp. was higher in MGLSc patients (0% [range 0-18%] vs. 0% [range 0-5%]). There was a strong association between the microbiota composition of the balanopreputial sac and urine in MGLSc.
Conclusion: Dysbiosis could be involved in the etiopathogenesis of MGLSc. Further studies are required to confirm the association suggested herein and to determine its nature.
(© 2020 the International Society of Dermatology.)
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معلومات مُعتمدة: RF-2016-0004 European Academy of Dermatology and Venereology; Skin Treatment and Research Trust
المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20201021 Date Completed: 20210617 Latest Revision: 20210617
رمز التحديث: 20240628
DOI: 10.1111/ijd.15252
PMID: 33084022
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-4632
DOI:10.1111/ijd.15252