دورية أكاديمية
أعرض في EDS

Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis.

التفاصيل البيبلوغرافية
العنوان: Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis.
المؤلفون: Wishart AL; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA., Conner SJ; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA., Guarin JR; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA., Fatherree JP; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA., Peng Y; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA., McGinn RA; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA., Crews R; Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA., Naber SP; Department of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA., Hunter M; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA., Greenberg AS; Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.; Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.; Tufts University School of Medicine, Boston, MA 02111, USA., Oudin MJ; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. madeleine.oudin@tufts.edu.
المصدر: Science advances [Sci Adv] 2020 Oct 21; Vol. 6 (43). Date of Electronic Publication: 2020 Oct 21 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
مواضيع طبية MeSH: Collagen Type VI*/metabolism , Decellularized Extracellular Matrix* , Obesity*/metabolism , Triple Negative Breast Neoplasms*/metabolism, Extracellular Matrix/metabolism ; Humans ; Neoplasm Invasiveness ; Tumor Microenvironment
مستخلص: The extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local invasion to drive metastasis. Here, we describe a method to study whole-tissue ECM effects from disease states associated with metastasis on tumor cell phenotypes and identify the individual ECM proteins and signaling pathways that are driving these effects. We show that decellularized ECM from tumor-bearing and obese mammary glands drives TNBC cell invasion. Proteomics of the ECM from the obese mammary gland led us to identify full-length collagen VI as a novel driver of TNBC cell invasion whose abundance in tumor stroma increases with body mass index in human TNBC patients. Last, we describe the mechanism by which collagen VI contributes to TNBC cell invasion via NG2-EGFR cross-talk and MAPK signaling. Overall, these studies demonstrate the value of decellularized ECM scaffolds obtained from tissues to identify novel functions of the ECM.
(Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
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معلومات مُعتمدة: S10 OD021624 United States OD NIH HHS; R21 HD098056 United States HD NICHD NIH HHS; R01 DK108722 United States DK NIDDK NIH HHS; T32 DK124170 United States DK NIDDK NIH HHS; P30 DK046200 United States DK NIDDK NIH HHS; R00 CA207866 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Collagen Type VI)
0 (Decellularized Extracellular Matrix)
تواريخ الأحداث: Date Created: 20201022 Date Completed: 20220413 Latest Revision: 20220719
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7577726
DOI: 10.1126/sciadv.abc3175
PMID: 33087348
قاعدة البيانات: MEDLINE
الوصف
تدمد:2375-2548
DOI:10.1126/sciadv.abc3175