دورية أكاديمية
Deconstructing tumor heterogeneity: the stromal perspective.
| العنوان: | Deconstructing tumor heterogeneity: the stromal perspective. |
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| المؤلفون: | Vickman RE; Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.; These authors contributed equally to this work., Faget DV; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO, USA.; These authors contributed equally to this work., Beachy P; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA., Beebe D; Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, USA., Bhowmick NA; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Cukierman E; Department of Cancer Biology, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, USA., Deng WM; Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA., Granneman JG; Department of Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA., Hildesheim J; National Cancer Institute, Bethesda, MD, USA., Kalluri R; Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX, USA., Lau KS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Lengyel E; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA., Lundeberg J; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden., Moscat J; Weill Cornell Medicine, Rockefeller University Campus, New York, NY, USA., Nelson PS; Department of Medicine, University of Washington, Seattle, WA, USA., Pietras K; Department of Laboratory Medicine, Lund University, Lund, Sweden., Politi K; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Puré E; Department of Biomedical Sciences, University of Pennsylvania, Philidelphia, PA, USA., Scherz-Shouval R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Sherman MH; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Tuveson D; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Weeraratna AT; Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., White RM; Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA., Wong MH; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Woodhouse EC; National Cancer Institute, Bethesda, MD, USA., Zheng Y; Department of Bioengineering, University of Washington, Seattle, WA, USA., Hayward SW; Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.; Workshop co-chairs., Stewart SA; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO, USA.; Workshop co-chairs. |
| المصدر: | Oncotarget [Oncotarget] 2020 Oct 06; Vol. 11 (40), pp. 3621-3632. Date of Electronic Publication: 2020 Oct 06 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, N.Y. : Impact Journals |
| مستخلص: | Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field. Competing Interests: CONFLICTS OF INTEREST Authors have no conflicts of interest to declare. (Copyright: © 2020 Vickman et al.) |
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| معلومات مُعتمدة: | R01 CA224381 United States CA NCI NIH HHS; R01 CA227789 United States CA NCI NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS; P30 CA010815 United States CA NCI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; U01 CA235747 United States CA NCI NIH HHS; R01 DK062292 United States DK NIDDK NIH HHS; R01 DK103831 United States DK NIDDK NIH HHS; P01 CA217805 United States CA NCI NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: cellular plasticity; extracellular matrix; stromal heterogeneity; therapy resistance; tumor microenvironment |
| تواريخ الأحداث: | Date Created: 20201022 Latest Revision: 20240329 |
| رمز التحديث: | 20240329 |
| مُعرف محوري في PubMed: | PMC7546755 |
| DOI: | 10.18632/oncotarget.27736 |
| PMID: | 33088423 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1949-2553 |
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| DOI: | 10.18632/oncotarget.27736 |