دورية أكاديمية
Epidemiology of Basal-like and Luminal Breast Cancers among Black Women in the AMBER Consortium.
| العنوان: | Epidemiology of Basal-like and Luminal Breast Cancers among Black Women in the AMBER Consortium. |
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| المؤلفون: | Benefield HC; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Zirpoli GR; Slone Epidemiology Center at Boston University, Boston, Massachusetts., Allott EH; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom., Shan Y; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Hurson AN; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Omilian AR; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Khoury T; Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York., Hong CC; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Olshan AF; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Bethea TN; Slone Epidemiology Center at Boston University, Boston, Massachusetts., Bandera EV; Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey., Palmer JR; Slone Epidemiology Center at Boston University, Boston, Massachusetts., Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Troester MA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. troester@unc.edu. |
| المصدر: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2021 Jan; Vol. 30 (1), pp. 71-79. Date of Electronic Publication: 2020 Oct 23. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7755 (Electronic) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research, c1991- |
| مواضيع طبية MeSH: | Breast Neoplasms/*ethnology , Receptor, ErbB-2/*genetics , Receptors, Estrogen/*genetics , Receptors, Progesterone/*genetics, Black or African American/statistics & numerical data ; Breast Neoplasms/genetics ; Female ; Humans ; Risk Factors ; Triple Negative Breast Neoplasms/ethnology |
| مستخلص: | Background: Evidence suggests etiologic heterogeneity among breast cancer subtypes. Previous studies with six-marker IHC classification of intrinsic subtypes included small numbers of black women. Methods: Using centralized laboratory results for estrogen receptor (ER), progesterone receptor, HER2, proliferation marker, Ki-67, EGFR, and cytokeratin (CK)5/6, we estimated case-only and case-control ORs for established breast cancer risk factors among cases ( n = 2,354) and controls ( n = 2,932) in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. ORs were estimated by ER status and intrinsic subtype using adjusted logistic regression. Results: Case-only analyses by ER status showed etiologic heterogeneity by age at menarche, parity (vs. nulliparity), and age at first birth. In case-control analyses for intrinsic subtype, increased body mass index and waist-to-hip ratio (WHR) were associated with increased risk of luminal A subtype, whereas older age at menarche and parity, regardless of breastfeeding, were associated with reduced risk. For basal-like cancers, parity without breastfeeding and increasing WHR were associated with increased risk, whereas breastfeeding and age ≥25 years at first birth were associated with reduced risk among parous women. Basal-like and ER - /HER2 + subtypes had earlier age-at-incidence distribution relative to luminal subtypes. Conclusions: Breast cancer subtypes showed distinct etiologic profiles in the AMBER consortium, a study of more than 5,000 black women with centrally assessed tumor biospecimens. Impact: Among black women, high WHR and parity without breastfeeding are emerging as important intervention points to reduce the incidence of basal-like breast cancer. (©2020 American Association for Cancer Research.) |
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| معلومات مُعتمدة: | U01 CA179715 United States CA NCI NIH HHS; K01 CA212056 United States CA NCI NIH HHS; P30 ES010126 United States ES NIEHS NIH HHS; P30 CA016056 United States CA NCI NIH HHS; P01 CA151135 United States CA NCI NIH HHS; P30 CA016086 United States CA NCI NIH HHS; P50 CA058223 United States CA NCI NIH HHS; R01 CA058420 United States CA NCI NIH HHS; F30 CA236199 United States CA NCI NIH HHS; R01 CA100598 United States CA NCI NIH HHS; U01 CA164974 United States CA NCI NIH HHS; R01 CA098663 United States CA NCI NIH HHS; UM1 CA164974 United States CA NCI NIH HHS; T32 CA057726 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Receptors, Estrogen) 0 (Receptors, Progesterone) EC 2.7.10.1 (Receptor, ErbB-2) |
| تواريخ الأحداث: | Date Created: 20201024 Date Completed: 20211126 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC8935955 |
| DOI: | 10.1158/1055-9965.EPI-20-0556 |
| PMID: | 33097496 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1538-7755 |
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| DOI: | 10.1158/1055-9965.EPI-20-0556 |