دورية أكاديمية
Daptomycin-based aminoglycoside-sparing therapy for streptococcal endocarditis: a retrospective multicenter study.
| العنوان: | Daptomycin-based aminoglycoside-sparing therapy for streptococcal endocarditis: a retrospective multicenter study. |
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| المؤلفون: | Pallotto C; Section of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy.; Infectious Diseases Unit 1, Santa Maria Annunziata Hospital, Central District, Tuscany Health Care, Bagno a Ripoli, Florence, Italy., Sbrana F; Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Ripoli A; Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Lupia T; Department of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy., Corcione S; Department of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy., Paciosi F; Section of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy., Francisci D; Section of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy., Pasticci MB; Section of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy., Sozio E; Emergency Department, Spedali Riuniti of Livorno, North-West District, Tuscany Health Care, Livorno, Italy., Bertolino G; Pharmaceutical Department, ASSL Cagliari, Cagliari, Italy., Carannante N; First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy., Rescigno C; First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy., Carozza A; UOSD Advanced Techniques in Cardiosurgery, Monaldi Hospital, AORN dei Colli, Naples, Italy., Di Caprio G; Infectious Diseases Unit, AORN Sant'Anna e San Sebastiano, Caserta, Italy., Taddei E; Institute of Infectious Diseases, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy., Murri R; Institute of Infectious Diseases, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy., Fantoni M; Institute of Infectious Diseases, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy., Emdin M; Fondazione Toscana Gabriele Monasterio, Pisa, Italy.; Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy., Aimo A; Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy., De Rosa FG; Department of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy., Tascini C; First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy.; SOC Infectious Diseases, Azienda Sanitaria Integrata del Friuli Centrale, Udine, Italy. |
| المصدر: | Journal of chemotherapy (Florence, Italy) [J Chemother] 2021 Oct; Vol. 33 (6), pp. 435-439. Date of Electronic Publication: 2020 Oct 25. |
| نوع المنشور: | Journal Article; Multicenter Study; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 8907348 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1973-9478 (Electronic) Linking ISSN: 1120009X NLM ISO Abbreviation: J Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Abingdon : Taylor & Francis Original Publication: Firenze : Edizioni riviste scientifiche, [1989- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*therapeutic use , Daptomycin/*therapeutic use , Endocarditis, Bacterial/*drug therapy , Streptococcal Infections/*drug therapy , beta-Lactams/*therapeutic use, Adult ; Aged ; Aminoglycosides/adverse effects ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Daptomycin/administration & dosage ; Daptomycin/adverse effects ; Drug Therapy, Combination ; Endocarditis, Bacterial/mortality ; Female ; Gentamicins/administration & dosage ; Humans ; Italy ; Male ; Middle Aged ; Renal Insufficiency/chemically induced ; Retrospective Studies ; Streptococcal Infections/mortality ; beta-Lactams/administration & dosage ; beta-Lactams/adverse effects |
| مستخلص: | Streptococci still represent common etiologic agents of infective endocarditis (IE). Although renal failure is frequently reported as an aminoglycoside-associated adverse event, last international guidelines recommend a beta-lactam/gentamicin combination therapy. We retrospectively evaluated the use of daptomycin-based aminoglycoside-sparing combination therapy for the treatment of streptococcal IE in seven referral hospitals in Italy. Retrospective, multicenter, observational study. All patients with streptococcal IE admitted from 2016 to 2018 were enrolled. Mortality and incidence of acute kidney injury (AKI) were compared between Group A (standard of care, SoC) and Group B (daptomycin-based aminoglycoside-sparing combination therapy). Fifty-four patients were enrolled, 33 in Group A and 21 in Group B. Mortality was 2/33 (6%) in Group A and 0 in Group B ( p = 0.681); AKI incidence was 8/33 (24%) in Group A and 0 in Group B ( p = 0.04). Daptomycin-based aminoglycoside-sparing combination therapy appears to be promising for the treatment of streptococcal endocarditis because of similar efficacy compared with SoC and significantly reduced incidence of AKI. |
| فهرسة مساهمة: | Keywords: Acute kidney injury; Aminoglycoside-sparing therapy; Daptomycin; Streptococcal endocarditis; endocarditis |
| المشرفين على المادة: | 0 (Aminoglycosides) 0 (Anti-Bacterial Agents) 0 (Gentamicins) 0 (beta-Lactams) NWQ5N31VKK (Daptomycin) |
| تواريخ الأحداث: | Date Created: 20201026 Date Completed: 20220117 Latest Revision: 20220117 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1080/1120009X.2020.1838830 |
| PMID: | 33103614 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1973-9478 |
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| DOI: | 10.1080/1120009X.2020.1838830 |