دورية أكاديمية
Home collection of nasal swabs for detection of influenza in the Household Influenza Vaccine Evaluation Study.
العنوان: | Home collection of nasal swabs for detection of influenza in the Household Influenza Vaccine Evaluation Study. |
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المؤلفون: | Malosh RE; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washingon Heights, Ann Arbor, MI, 48109, USA., Petrie JG; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washingon Heights, Ann Arbor, MI, 48109, USA., Callear AP; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washingon Heights, Ann Arbor, MI, 48109, USA., Monto AS; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washingon Heights, Ann Arbor, MI, 48109, USA., Martin ET; Department of Epidemiology, University of Michigan School of Public Health, 1415 Washingon Heights, Ann Arbor, MI, 48109, USA. |
المصدر: | Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2021 Mar; Vol. 15 (2), pp. 227-234. Date of Electronic Publication: 2020 Oct 26. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 101304007 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2659 (Electronic) Linking ISSN: 17502640 NLM ISO Abbreviation: Influenza Other Respir Viruses Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford, UK : Wiley, c2007- |
مواضيع طبية MeSH: | Specimen Handling*, Influenza, Human/*diagnosis , Nasal Cavity/*virology , Orthomyxoviridae/*isolation & purification, Feasibility Studies ; Humans ; Orthomyxoviridae/classification ; Orthomyxoviridae/genetics ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity |
مستخلص: | Background: Community-based studies of influenza and other respiratory viruses (eg, SARS-CoV-2) require laboratory confirmation of infection. During the current COVID-19 pandemic, social distancing guidelines require alternative data collection in order to protect both research staff and participants. Home-collected respiratory specimens are less resource-intensive, can be collected earlier after symptom onset, and provide a low-contact means of data collection. A prospective, multi-year, community-based cohort study is an ideal setting to examine the utility of home-collected specimens for identification of influenza. Methods: We describe the feasibility and reliability of home-collected specimens for the detection of influenza. We collected data and specimens between October 2014 and June 2017 from the Household Influenza Vaccine Evaluation (HIVE) Study. Cohort participants were asked to collect a nasal swab at home upon onset of acute respiratory illness. Research staff also collected nose and throat swab specimens in the study clinic within 7 days of onset. We estimated agreement using Cohen's kappa and calculated sensitivity and specificity of home-collected compared to staff-collected specimens. Results: We tested 336 paired staff- and home-collected respiratory specimens for influenza by RT-PCR; 150 staff-collected specimens were positive for influenza A/H3N2, 23 for influenza A/H1N1, 14 for influenza B/Victoria, and 31 for influenza B/Yamagata. We found moderate agreement between collection methods for influenza A/H3N2 (0.70) and B/Yamagata (0.69) and high agreement for influenza A/H1N1 (0.87) and B/Victoria (0.86). Sensitivity ranged from 78% to 86% for all influenza types and subtypes. Specificity was high for influenza A/H1N1 and both influenza B lineages with a range from 96% to 100%, and slightly lower for A/H3N2 infections (88%). Conclusions: Collection of nasal swab specimens at home is both feasible and reliable for identification of influenza virus infections. (© 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.) |
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معلومات مُعتمدة: | U01 IP001034 United States IP NCIRD CDC HHS; R01 AI097150 United States AI NIAID NIH HHS; U01 IP000474 United States CC CDC HHS |
فهرسة مساهمة: | Keywords: acute respiratory illness; community-based; influenza; self-collected nasal swabs |
تواريخ الأحداث: | Date Created: 20201027 Date Completed: 20210309 Latest Revision: 20221009 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7902250 |
DOI: | 10.1111/irv.12822 |
PMID: | 33107200 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1750-2659 |
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DOI: | 10.1111/irv.12822 |