دورية أكاديمية
أعرض في EDS

ATRIP protects progenitor cells against DNA damage in vivo.

التفاصيل البيبلوغرافية
العنوان: ATRIP protects progenitor cells against DNA damage in vivo.
المؤلفون: Matos-Rodrigues GE; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Institut Cochin, INSERM U1016, UMR8104 CNRS, Université Paris-Descartes, Equipe Labellisée Ligue Contre le Cancer, 24 rue du Faubourg St Jacques, 75014, Paris, France., Grigaravicius P; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany.; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), D-07745, Jena, Germany., Lopez BS; Institut Cochin, INSERM U1016, UMR8104 CNRS, Université Paris-Descartes, Equipe Labellisée Ligue Contre le Cancer, 24 rue du Faubourg St Jacques, 75014, Paris, France., Hofmann TG; Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Frappart PO; Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. pfrappar@uni-mainz.de., Martins RAP; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. rodrigo.martins@icb.ufrj.br.
المصدر: Cell death & disease [Cell Death Dis] 2020 Oct 28; Vol. 11 (10), pp. 923. Date of Electronic Publication: 2020 Oct 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Pub. Group
مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*genetics , DNA Damage/*genetics , DNA Replication/*genetics , DNA-Binding Proteins/*genetics , Stem Cells/*metabolism, Animals ; Cell Proliferation ; Humans ; Mice
مستخلص: The maintenance of genomic stability during the cell cycle of progenitor cells is essential for the faithful transmission of genetic information. Mutations in genes that ensure genome stability lead to human developmental syndromes. Mutations in Ataxia Telangiectasia and Rad3-related (ATR) or in ATR-interacting protein (ATRIP) lead to Seckel syndrome, which is characterized by developmental malformations and short life expectancy. While the roles of ATR in replicative stress response and chromosomal segregation are well established, it is unknown how ATRIP contributes to maintaining genomic stability in progenitor cells in vivo. Here, we generated the first mouse model to investigate ATRIP function. Conditional inactivation of Atrip in progenitor cells of the CNS and eye led to microcephaly, microphthalmia and postnatal lethality. To understand the mechanisms underlying these malformations, we used lens progenitor cells as a model and found that ATRIP loss promotes replicative stress and TP53-dependent cell death. Trp53 inactivation in Atrip-deficient progenitor cells rescued apoptosis, but increased mitotic DNA damage and mitotic defects. Our findings demonstrate an essential role of ATRIP in preventing DNA damage accumulation during unchallenged replication.
التعليقات: Erratum in: Cell Death Dis. 2020 Dec 15;11(12):1074. (PMID: 33323930)
References: Cell Death Differ. 2018 Jan;25(1):93-103. (PMID: 29099489)
Nat Genet. 2009 Aug;41(8):891-8. (PMID: 19620979)
EMBO J. 2012 Mar 7;31(5):1177-89. (PMID: 22266795)
Science. 2018 Aug 24;361(6404):806-810. (PMID: 30139873)
Genes Dev. 2000 Feb 15;14(4):397-402. (PMID: 10691732)
Science. 1998 Sep 11;281(5383):1674-7. (PMID: 9733514)
Nature. 2009 Oct 22;461(7267):1071-8. (PMID: 19847258)
Can J Ophthalmol. 2014 Oct;49(5):e130-1. (PMID: 25284118)
Cell Stem Cell. 2007 Jun 7;1(1):113-26. (PMID: 18371340)
Genes Dev. 2011 Oct 1;25(19):2011-24. (PMID: 21979914)
Mol Cell. 2010 Oct 22;40(2):179-204. (PMID: 20965415)
Genes Dev. 2013 Jul 1;27(13):1484-94. (PMID: 23824539)
Curr Biol. 2000 Apr 20;10(8):479-82. (PMID: 10801416)
Cold Spring Harb Perspect Biol. 2012 Dec 01;4(12):. (PMID: 23209155)
PLoS One. 2014 Feb 04;9(2):e87182. (PMID: 24503550)
DNA Repair (Amst). 2009 Nov 2;8(11):1333-7. (PMID: 19782648)
Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27. (PMID: 18594563)
J Neurosci. 2017 Jan 25;37(4):893-905. (PMID: 28123024)
J Clin Invest. 2019 Mar 1;129(3):1329-1344. (PMID: 30645202)
Mol Gen Genet. 1996 Apr 24;251(1):1-12. (PMID: 8628240)
Mol Cell Biol. 1992 Nov;12(11):5041-9. (PMID: 1406679)
Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-1335. (PMID: 22120667)
Nat Rev Cancer. 2009 Oct;9(10):714-23. (PMID: 19730431)
Nat Rev Mol Cell Biol. 2017 Oct;18(10):622-636. (PMID: 28811666)
Cell Rep. 2013 Nov 27;5(4):1095-107. (PMID: 24268773)
Eur J Neurosci. 2006 Aug;24(4):969-80. (PMID: 16925590)
DNA Repair (Amst). 2008 Jul 1;7(7):1051-60. (PMID: 18458002)
Nucleic Acids Res. 2018 Mar 16;46(5):2479-2494. (PMID: 29361157)
Genes Dev. 1999 Jan 15;13(2):152-7. (PMID: 9925639)
Science. 2018 Jan 5;359(6371):108-114. (PMID: 29170278)
Nat Rev Cancer. 2018 Sep;18(9):586-595. (PMID: 29899559)
Dev Biol. 2005 Apr 1;280(1):1-14. (PMID: 15766743)
Development. 2014 Dec;141(23):4432-47. (PMID: 25406393)
Cancer Res. 2014 Dec 15;74(24):7534-45. (PMID: 25336189)
Blood. 2016 Feb 4;127(5):582-95. (PMID: 26563132)
Nature. 1994 Sep 1;371(6492):72-4. (PMID: 8072529)
Genesis. 2007 Apr;45(4):157-68. (PMID: 17410548)
Cancer Res. 2017 Oct 15;77(20):5576-5590. (PMID: 28790064)
Science. 2001 Nov 23;294(5547):1713-6. (PMID: 11721054)
Sci Signal. 2016 Sep 13;9(445):ra91. (PMID: 27625305)
Development. 2016 Nov 1;143(21):4038-4052. (PMID: 27803059)
Am J Ophthalmol. 2001 Oct;132(4):596-7. (PMID: 11589896)
Mol Cell. 2016 Dec 15;64(6):1117-1126. (PMID: 27984745)
Trends Genet. 2017 Oct;33(10):677-702. (PMID: 28867048)
Genes Dev. 2008 Jan 15;22(2):179-93. (PMID: 18198336)
J Biol Chem. 2001 Nov 9;276(45):42462-7. (PMID: 11571274)
Genes Dev. 2000 Nov 1;14(21):2701-11. (PMID: 11069887)
J Cataract Refract Surg. 2007 May;33(5):910-2. (PMID: 17466870)
المشرفين على المادة: 0 (ATRIP protein, human)
0 (Adaptor Proteins, Signal Transducing)
0 (DNA-Binding Proteins)
تواريخ الأحداث: Date Created: 20201028 Date Completed: 20210517 Latest Revision: 20210517
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7591577
DOI: 10.1038/s41419-020-03090-9
PMID: 33110058
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-4889
DOI:10.1038/s41419-020-03090-9