دورية أكاديمية
أعرض في EDS

Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties.

التفاصيل البيبلوغرافية
العنوان: Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties.
المؤلفون: Joshi Navare K; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA., Colombani T; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA., Rezaeeyazdi M; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA., Bassous N; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA., Rana D; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA., Webster T; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.; Wenzhou Institute for Biomaterials and Engineering, Wenzhou, 325001, China., Memic A; Center of Nanotechnology, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Bencherif SA; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA. s.bencherif@northeastern.edu.; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA. s.bencherif@northeastern.edu.; Sorbonne University, UTC CNRS UMR 7338, Biomechanics and Bioengineering (BMBI), University of Technology of Compiègne, 60203, Compiègne, France. s.bencherif@northeastern.edu.; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA. s.bencherif@northeastern.edu.
المصدر: Scientific reports [Sci Rep] 2020 Oct 27; Vol. 10 (1), pp. 18370. Date of Electronic Publication: 2020 Oct 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Cryogels* , Needles* , Tissue Engineering*, Anti-Infective Agents/*pharmacology, Animals ; Biocompatible Materials ; Biomimetics ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells
مستخلص: Porous three-dimensional hydrogel scaffolds have an exquisite ability to promote tissue repair. However, because of their high water content and invasive nature during surgical implantation, hydrogels are at an increased risk of bacterial infection. Recently, we have developed elastic biomimetic cryogels, an advanced type of polymeric hydrogel, that are syringe-deliverable through hypodermic needles. These needle-injectable cryogels have unique properties, including large and interconnected pores, mechanical robustness, and shape-memory. Like hydrogels, cryogels are also susceptible to colonization by microbial pathogens. To that end, our minimally invasive cryogels have been engineered to address this challenge. Specifically, we hybridized the cryogels with calcium peroxide microparticles to controllably produce bactericidal hydrogen peroxide. Our novel microcomposite cryogels exhibit antimicrobial properties and inhibit antibiotic-resistant bacteria (MRSA and Pseudomonas aeruginosa), the most common cause of biomaterial implant failure in modern medicine. Moreover, the cryogels showed negligible cytotoxicity toward murine fibroblasts and prevented activation of primary bone marrow-derived dendritic cells ex vivo. Finally, in vivo data suggested tissue integration, biodegradation, and minimal host inflammatory responses when the antimicrobial cryogels, even when purposely contaminated with bacteria, were subcutaneously injected in mice. Collectively, these needle-injectable microcomposite cryogels show great promise for biomedical applications, especially in tissue engineering and regenerative medicine.
References: Int J Nanomedicine. 2012;7:6003-9. (PMID: 23233805)
J Biomed Mater Res A. 2009 Jul;90(1):142-53. (PMID: 18491397)
Biomater Sci. 2020 Aug 7;8(15):4073-4094. (PMID: 32539055)
Materials (Basel). 2018 Mar 19;11(3):. (PMID: 29562729)
Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:408-18. (PMID: 27157768)
ACS Biomater Sci Eng. 2017 May 8;3(5):787-792. (PMID: 33440492)
Adv Healthc Mater. 2014 Apr;3(4):500-7. (PMID: 24030924)
J Bone Jt Infect. 2016 Jul 19;1:34-41. (PMID: 28529851)
Trends Biotechnol. 2020 Apr;38(4):418-431. (PMID: 31699534)
Tissue Eng Part A. 2017 Mar;23(5-6):243-251. (PMID: 27875939)
J R Soc Interface. 2011 Apr 6;8(57):540-54. (PMID: 20943683)
Nat Protoc. 2017 Aug;12(8):1521-1541. (PMID: 28683063)
ACS Appl Bio Mater. 2019 Mar 18;2(3):952-969. (PMID: 35021385)
ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9221-9225. (PMID: 28266838)
Int Endod J. 2007 Jan;40(1):2-10. (PMID: 17209826)
J Bacteriol. 2008 Apr;190(8):2663-70. (PMID: 18165301)
Carbohydr Polym. 2013 Feb 15;92(2):1262-79. (PMID: 23399155)
ACS Macro Lett. 2016 May 17;5(5):552-557. (PMID: 35632386)
Int J Nanomedicine. 2018 Sep 24;13:5637-5655. (PMID: 30288038)
Biopolymers. 2013 Nov;100(6):637-44. (PMID: 24122459)
Chem Rev. 2016 Feb 10;116(3):1496-539. (PMID: 26492834)
Biomaterials. 2008 Apr;29(12):1739-49. (PMID: 18234331)
Nanomaterials (Basel). 2017 Dec 10;7(12):. (PMID: 29232876)
Int Endod J. 1999 Sep;32(5):361-9. (PMID: 10551109)
Wiley Interdiscip Rev Syst Biol Med. 2012 Mar-Apr;4(2):207-20. (PMID: 22012681)
Acta Biomater. 2017 Oct 15;62:29-41. (PMID: 28851666)
Biotechnol Bioeng. 2003 Jun 5;82(5):578-89. (PMID: 12652481)
J Bacteriol. 2013 May;195(9):2011-20. (PMID: 23457248)
ACS Appl Mater Interfaces. 2014 Oct 22;6(20):18078-86. (PMID: 25253647)
Ann Biomed Eng. 2015 Mar;43(3):515-28. (PMID: 25476163)
Polym Int. 2013 Jun 1;62(6):843-848. (PMID: 23853426)
Nat Rev Mater. 2016 Dec;1(12):. (PMID: 29657852)
Polymers (Basel). 2020 May 29;12(6):. (PMID: 32485817)
J Biomater Sci Polym Ed. 2017 Sep;28(13):1324-1337. (PMID: 28422569)
Nat Commun. 2018 Jul 17;9(1):2784. (PMID: 30018305)
J Biomater Appl. 2012 Feb;26(6):745-59. (PMID: 21123283)
Semin Immunol. 2008 Apr;20(2):86-100. (PMID: 18162407)
Soft Matter. 2012;8(12):3280-3294. (PMID: 22419946)
Adv Drug Deliv Rev. 2006 Dec 1;58(14):1523-31. (PMID: 17079050)
Acta Biomater. 2009 Jul;5(6):1872-83. (PMID: 19328754)
Biotechnol Bioeng. 2012 Aug;109(8):1898-911. (PMID: 22592568)
ACS Appl Mater Interfaces. 2018 May 2;10(17):15163-15173. (PMID: 29648438)
ACS Appl Mater Interfaces. 2018 Apr 25;10(16):13304-13316. (PMID: 29607644)
Nat Commun. 2015 Aug 12;6:7556. (PMID: 26265369)
Materials (Basel). 2018 Aug 07;11(8):. (PMID: 30087295)
Macromol Rapid Commun. 2014 Sep;35(18):1578-86. (PMID: 25113941)
Int J Biol Macromol. 2016 Dec;93(Pt B):1410-1419. (PMID: 27185069)
Nat Commun. 2014 Jun 24;5:4095. (PMID: 24958189)
Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19590-5. (PMID: 23150549)
Curr Med Chem. 2019;26(38):6834-6850. (PMID: 31284851)
Bioelectricity. 2020 Sep 1;2(3):279-292. (PMID: 34476358)
Gels. 2019 Dec 03;5(4):. (PMID: 31816989)
Chonnam Med J. 2012 Dec;48(3):133-40. (PMID: 23323217)
ACS Appl Mater Interfaces. 2018 May 23;10(20):17018-17027. (PMID: 29693373)
Int J Biol Macromol. 2016 May;86:917-28. (PMID: 26893053)
Expert Rev Med Devices. 2011 Sep;8(5):607-26. (PMID: 22026626)
Biomaterials. 2009 Jun;30(18):3129-35. (PMID: 19339046)
Nat Mater. 2011 Feb;10(2):149-56. (PMID: 21151166)
Bioresour Technol. 2013 Oct;145:280-4. (PMID: 23558181)
Biomacromolecules. 2009 Jun 8;10(6):1429-35. (PMID: 19405545)
Adv Healthc Mater. 2015 Jan 28;4(2):301-12. (PMID: 25178838)
Arthritis Res. 2002;4 Suppl 3:S127-32. (PMID: 12110131)
Wien Med Wochenschr. 2019 Jun;169(9-10):222-225. (PMID: 29147868)
Biomacromolecules. 2010 Mar 8;11(3):769-75. (PMID: 20148576)
ACS Appl Mater Interfaces. 2016 Jun 22;8(24):15145-59. (PMID: 27223844)
Biomaterials. 2013 Aug;34(24):5969-77. (PMID: 23680363)
ACS Appl Mater Interfaces. 2011 Jan;3(1):67-73. (PMID: 21155527)
Am J Infect Control. 1998 Apr;26(2):94-101. (PMID: 9584802)
Nanomaterials (Basel). 2017 Mar 13;7(3):. (PMID: 28336896)
J Biomater Appl. 2011 Nov;26(4):383-417. (PMID: 21926148)
J Mater Chem B. 2016 Mar 14;4(10):1827-1841. (PMID: 32263060)
Tissue Eng Part B Rev. 2017 Feb;23(1):9-26. (PMID: 27405960)
J Periodontal Implant Sci. 2013 Dec;43(6):251-61. (PMID: 24455437)
Biomaterials. 2011 May;32(13):3423-34. (PMID: 21324403)
Adv Healthc Mater. 2018 May;7(10):e1701469. (PMID: 29441705)
Int J Mol Sci. 2019 Feb 01;20(3):. (PMID: 30717232)
Biomed Mater. 2015 Dec 23;11(1):014104. (PMID: 26694229)
Cytokine Growth Factor Rev. 2008 Feb;19(1):41-52. (PMID: 18258476)
Adv Healthc Mater. 2019 Sep;8(17):e1900679. (PMID: 31348620)
ACS Appl Mater Interfaces. 2017 Apr 05;9(13):11428-11439. (PMID: 28140564)
المشرفين على المادة: 0 (Anti-Infective Agents)
0 (Biocompatible Materials)
0 (Cryogels)
تواريخ الأحداث: Date Created: 20201028 Date Completed: 20210310 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC7591905
DOI: 10.1038/s41598-020-75196-1
PMID: 33110210
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-75196-1