دورية أكاديمية
أعرض في EDS

SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells.

التفاصيل البيبلوغرافية
العنوان: SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells.
المؤلفون: Mansour MA; Division of Human Sciences, School of Applied Sciences, London South Bank University, London, UK.; Biochemistry Division, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt.
المصدر: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Mar; Vol. 35 (3), pp. e22657. Date of Electronic Publication: 2020 Oct 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Wiley, c1998-
مواضيع طبية MeSH: Cell Movement* , Signal Transduction*, Breast Neoplasms/*metabolism , Proto-Oncogene Proteins c-akt/*metabolism , Sp3 Transcription Factor/*metabolism, Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; MCF-7 Cells ; Neoplasm Invasiveness ; Proto-Oncogene Proteins c-akt/genetics ; Sp3 Transcription Factor/genetics
مستخلص: Specificity proteins (SPs) have pro-oncogenic functions in cancer cells, ranging from cancer cell proliferation, migration, invasion, and angiogenesis. There is strong evidence that several antineoplastic drugs target depletion of SP proteins via different pathways. However, the mode of action of SP3 and the underlying consequences of its depletion are not well understood. Here, we demonstrate that SP3 is overexpressed in invasive breast cancer cells vs normal counterparts. The gene expression analysis from The Cancer Genome Atlas datasets indicated that SP3 is strongly correlated with Akt signalling-related proteins, G protein subunit alpha 13, and RAB33B (RAB33B, member RAS oncogene family). RNA interference of SP3 decreased active phosphorylation of Akt at serine and threonine sites. These findings indicate that SP3 exhibits a pro-oncogenic function, which clearly fits the description of an nononcogene addiction gene. Future analyses are prompted to uncover the SP3 gene regulation function and to reveal downstream targets of SP3 in breast cancer.
(© 2020 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: Akt signalling; GNA13; SP3; breast cancer; transcription factor
المشرفين على المادة: 0 (SP3 protein, human)
148710-94-5 (Sp3 Transcription Factor)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
تواريخ الأحداث: Date Created: 20201028 Date Completed: 20210713 Latest Revision: 20210713
رمز التحديث: 20240628
DOI: 10.1002/jbt.22657
PMID: 33113244
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-0461
DOI:10.1002/jbt.22657