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Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting.

التفاصيل البيبلوغرافية
العنوان: Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting.
المؤلفون: Okunromade O; Nigeria Centre for Disease Control, Abuja, Nigeria., Dalhat MM; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Umar AM; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Dada AO; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Nikau J; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Maneh L; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Ita OI; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Balogun MS; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Nguku P; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria., Ojo O; Nigeria Centre for Disease Control, Abuja, Nigeria., Ihekweazu C; Nigeria Centre for Disease Control, Abuja, Nigeria.
المصدر: The Pan African medical journal [Pan Afr Med J] 2020 Aug 17; Vol. 36, pp. 287. Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kampala, Uganda : African Field Epidemiology Network
مواضيع طبية MeSH: Disease Outbreaks*, Botulinum Toxins/*poisoning , Botulism/*diagnosis, Adolescent ; Animals ; Botulinum Antitoxin/administration & dosage ; Botulinum Toxins/isolation & purification ; Botulism/therapy ; Clostridium botulinum/isolation & purification ; Female ; Fishes/microbiology ; Food Contamination ; Food Microbiology ; Humans ; Male ; Middle Aged ; Nigeria ; Surveys and Questionnaires
مستخلص: Food-borne botulism is a rare, acute and potentially fatal neurologic disorder that results from ingestion of food contaminated by botulinum toxin released from the anaerobic, spore-forming, gram-positive bacterium Clostridium botulinum. We reported an unusual cluster of botulism outbreak with high case fatality affecting a family following ingestion of home-made fish. A suspected outbreak of botulism affecting three patients in a family of six was reported to the Nigeria Centre for Disease Control. A rapid response team investigated by line-listing all the family members, interviewed extended family members, caregivers, clinicians, and nurses to collect socio-demographic and clinico epidemiological information using a semi-structured questionnaires. We collected blood from patients and food samples and locally made drink from the family home for laboratory testing. All family members ingested the same home-made food within the 48hrs before onset of symptoms in the index case. The clinical presentation of the three affected cases (AR=50.0%) was consistent with botulinum poisoning. Two of the affected cases died (CFR=66.7%) within 48hrs of admission, before antitoxin was made available. The third case had a milder presentation and survived, after administration of appropriate antitoxin. The remaining three children developed no symptoms. None of the samples cultured Clostridium botulinum. The blood samples were negative for mouse lethality test. Our report describes the challenges of diagnosis and management of rare emerging infectious disease outbreaks in resource-constrained settings.
Competing Interests: The authors declare no conflict of interests.
(Copyright: Oyeladun Okunromade et al.)
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فهرسة مساهمة: Keywords: Case report; anti-toxin; botulinum; botulism; mouse assay
المشرفين على المادة: 0 (Botulinum Antitoxin)
EC 3.4.24.69 (Botulinum Toxins)
تواريخ الأحداث: Date Created: 20201029 Date Completed: 20210114 Latest Revision: 20210114
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7572660
DOI: 10.11604/pamj.2020.36.287.20872
PMID: 33117481
قاعدة البيانات: MEDLINE
الوصف
تدمد:1937-8688
DOI:10.11604/pamj.2020.36.287.20872