دورية أكاديمية
HLA-B*51 and its main subtypes in Brazilian patients with Behçet's disease.
| العنوان: | HLA-B*51 and its main subtypes in Brazilian patients with Behçet's disease. |
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| المؤلفون: | Belem JMFM; Rheumatology Division, Department of Medicine, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil., Fraga AM; Fleury Group, Research and Development, São Paulo, Brazil., Andrade LEC; Rheumatology Division, Department of Medicine, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, and Fleury Group, Research and Development, São Paulo, Brazil., de Souza AWS; Rheumatology Division, Department of Medicine, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, and Fleury Group, Research and Development, São Paulo, Brazil. alexandre_wagner@uol.com.br. |
| المصدر: | Clinical and experimental rheumatology [Clin Exp Rheumatol] 2020 Sep-Oct; Vol. 38 Suppl 127 (5), pp. 53-59. Date of Electronic Publication: 2020 Oct 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Clinical And Experimental Rheumatology S.A.S Country of Publication: Italy NLM ID: 8308521 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0392-856X (Print) Linking ISSN: 0392856X NLM ISO Abbreviation: Clin Exp Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Pisa : Clinical And Experimental Rheumatology S.A.S Original Publication: Pisa, Italy : Pacini editore, [1983- |
| مواضيع طبية MeSH: | Behcet Syndrome*/diagnosis , Behcet Syndrome*/epidemiology , Behcet Syndrome*/genetics, Brazil ; Cross-Sectional Studies ; HLA-B Antigens/genetics ; HLA-B51 Antigen/genetics ; Humans |
| مستخلص: | Objectives: This study aimed to evaluate the frequency of HLA-B*51 and its subtypes in Brazilian patients with Behçet's disease (BD) and healthy controls (HC) and to assess possible associations with disease manifestations. Methods: A cross-sectional study with sequential BD patients and HC. HLAB*51 presence was determined by sequence-specific polymerase chain reaction (SSP-PCR) and HLA-B*51 subtypes by the Sanger sequencing method. Results: Eighty-three BD patients and 258 HC were evaluated. HLA-B*51 was found in 30.1% of DB patients and in 15.5% of HC (p=0.003). The most prevalent subtypes in DB patients were HLA-B*51:01 (60.0%), HLA-B*51:08 (20.0%), HLA-B*51:22 (8.0%), HLAB* 51:29 (8.0%) and HLA-B*51:02 (4.0%), while HLA-B*51:01 (77.5%) and HLA-B*51:55 (7.5%) were the most prevalent in HC. HLA-B*51 was less frequently found in patients with neurologic involvement (8.0% vs. 29.3%; p=0.034) while HLAB*51:01 was more observed in patients with ocular involvement (93.3% vs. 60.3%; p=0.014). No BD patient with neurologic or vascular involvement presented HLA-B*51:01. HLAB*51:08 was more frequent in patients with vascular manifestations (60.0% vs. 15.4%; p=0.012). In multivariate analysis, HLA-B*51 was an independent risk factor for BD (OR=2.410; 95%CI: 1.332-4.361; p=0.004) and HLA-B*51:08 had an independent association with vascular manifestations of BD (OR = 14.843; 95%CI: 1.550 - 142.115; p=0.019). Conclusions: The prevalence of HLAB*51 is higher in Brazilian BD patients compared to HC, and it is a risk factor for BD. The HLA-B*51:08 subtype was independently associated with vascular manifestations of BD. |
| المشرفين على المادة: | 0 (HLA-B Antigens) 0 (HLA-B51 Antigen) |
| تواريخ الأحداث: | Date Created: 20201030 Date Completed: 20201218 Latest Revision: 20201218 |
| رمز التحديث: | 20221213 |
| PMID: | 33124572 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0392-856X |
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