دورية أكاديمية
أعرض في EDS

Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.

التفاصيل البيبلوغرافية
العنوان: Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
المؤلفون: Domingueti CB; Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil., Castilho DAQ; Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil., de Oliveira CE; Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil., Janini JBM; Institute of Diagnostic and Prevention (IPD Laboratory), Varginha, Minas Gerais, Brazil., González-Arriagada WA; Centro de Investigación en Ciencias Odontológicas y Médicas, Facultad de Odontología, Universidad de Valparaíso, Valparaíso, Chile., Salo T; Cancer and Translational Medicine Research Unit, Faculty of Medicine and Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland; Institute of Oral and Maxillofacial Disease, University of Helsinki, and HUSLAB, Department of Pathology, Helsinki University Hospital, Helsinki, Finland., Coletta RD; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil., Paranaíba LMR; Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil. Electronic address: Liviaparanaib@gmail.com.
المصدر: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2020 Dec; Vol. 130 (6), pp. 700-707.e2. Date of Electronic Publication: 2020 Sep 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101576782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-4411 (Electronic) NLM ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier
مواضيع طبية MeSH: Cancer-Associated Fibroblasts* , Carcinoma, Squamous Cell* , Mouth Neoplasms*, Biomarkers, Tumor ; Collagen Type I ; Humans ; Kaplan-Meier Estimate ; Peptide Elongation Factor 1 ; Prognosis
مستخلص: Objective: Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in OSCCs and their levels are closely related to the prognosis of tumors. Our aim was to confirm the role of those markers in OSCC prognosis.
Study Design: Immunohistochemistry was performed in 90 OSCC specimens. The associations between clinicopathologic features and expression of markers were assessed by χ 2 test. Kaplan-Meier curves and univariate and multivariate Cox regression models were used for survival analysis. Markers were analyzed individually and in combination.
Results: High expression of EEF1D (P = .017) and PINP (P = .02) and abundant density of CAFs in tumor stroma (P = .005) predicted significantly poor survival in OSCC patients. Multivariate analysis revealed that all 3 parameters are individually independent prognostic factors of OSCC patients, and their combination improved the discrimination of patients at high risk for poor survival.
Conclusions: Our results suggested that the expression of EEF1D and PINP and the density of CAFs might influence the survival of patients with OSCC.
(Copyright © 2020. Published by Elsevier Inc.)
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Collagen Type I)
0 (Peptide Elongation Factor 1)
تواريخ الأحداث: Date Created: 20201102 Date Completed: 20201126 Latest Revision: 20201126
رمز التحديث: 20221213
DOI: 10.1016/j.oooo.2020.09.003
PMID: 33132084
قاعدة البيانات: MEDLINE
الوصف
تدمد:2212-4411
DOI:10.1016/j.oooo.2020.09.003