دورية أكاديمية
أعرض في EDS

Genome-scale metabolic reconstruction of the non-model yeast Issatchenkia orientalis SD108 and its application to organic acids production.

التفاصيل البيبلوغرافية
العنوان: Genome-scale metabolic reconstruction of the non-model yeast Issatchenkia orientalis SD108 and its application to organic acids production.
المؤلفون: Suthers PF; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA., Dinh HV; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA., Fatma Z; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Shen Y; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Chan SHJ; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA., Rabinowitz JD; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Zhao H; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champagne, Urbana, IL, USA., Maranas CD; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
المصدر: Metabolic engineering communications [Metab Eng Commun] 2020 Oct 08; Vol. 11, pp. e00148. Date of Electronic Publication: 2020 Oct 08 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101642117 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-0301 (Electronic) Linking ISSN: 22140301 NLM ISO Abbreviation: Metab Eng Commun Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2014]-
مستخلص: Many platform chemicals can be produced from renewable biomass by microorganisms, with organic acids making up a large fraction. Intolerance to the resulting low pH growth conditions, however, remains a challenge for the industrial production of organic acids by microorganisms. Issatchenkia orientalis SD108 is a promising host for industrial production because it is tolerant to acidic conditions as low as pH 2.0. With the goal to systematically assess the metabolic capabilities of this non-model yeast, we developed a genome-scale metabolic model for I. orientalis SD108 spanning 850 genes, 1826 reactions, and 1702 metabolites. In order to improve the model's quantitative predictions, organism-specific macromolecular composition and ATP maintenance requirements were determined experimentally and implemented. We examined its network topology, including essential genes and flux coupling analysis and drew comparisons with the Yeast 8.3 model for Saccharomyces cerevisiae . We explored the carbon substrate utilization and examined the organism's production potential for the industrially-relevant succinic acid, making use of the OptKnock framework to identify gene knockouts which couple production of the targeted chemical to biomass production. The genome-scale metabolic model iIsor 850 is a data-supported curated model which can inform genetic interventions for overproduction.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2020 The Authors.)
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فهرسة مساهمة: Keywords: Constraint-based modeling; Genome-scale model; Metabolic engineering; Non-model yeast
تواريخ الأحداث: Date Created: 20201102 Latest Revision: 20201103
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7586132
DOI: 10.1016/j.mec.2020.e00148
PMID: 33134082
قاعدة البيانات: MEDLINE
الوصف
تدمد:2214-0301
DOI:10.1016/j.mec.2020.e00148