دورية أكاديمية
أعرض في EDS

Important considerations for drugs, nutritional, and herbal supplements in pediatric solid organ transplant recipients.

التفاصيل البيبلوغرافية
العنوان: Important considerations for drugs, nutritional, and herbal supplements in pediatric solid organ transplant recipients.
المؤلفون: Pilch NA; Department of Pharmacy Practice and Outcomes Sciences, Transplant ICCE, Medical University of South Carolina, Charleston, SC, USA., Sell ML; Pediatrics/Solid Organ Transplant and Surgery, Transplant ICCE, Medical University of South Carolina, Charleston, SC, USA., McGhee W; Transplantation Ambulatory Care, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Venkataramanan R; School of Pharmacy and Medicine, Thomas Starzl Transplantation Institute, UPMC, Pittsburgh, PA, USA.
المصدر: Pediatric transplantation [Pediatr Transplant] 2021 Feb; Vol. 25 (1), pp. e13881. Date of Electronic Publication: 2020 Nov 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997-
مواضيع طبية MeSH: Diet, Healthy* , Dietary Supplements* , Transplant Recipients*, Immunosuppressive Agents/*therapeutic use , Nonprescription Drugs/*therapeutic use, Adolescent ; Child ; Drug Interactions ; Drugs, Generic/therapeutic use ; Humans ; Therapeutic Equivalency
مستخلص: Pediatric transplant recipients are on multiple prescription and non-prescription drugs. Many patients also use dietary, nutritional, and herbal supplements. This manuscript researched formulations of immunosuppressive drugs currently available and presents information on generic immunosuppressive drugs, commonly used non-prescription medications, dietary supplements, and herbal supplements. Immunosuppressive drugs are available in various formulations. Not all formulations are interchangeable. A number of FDA-approved generic formulations are available commercially in the United States. Generally generic formulations produce similar blood concentration vs time profiles compared to brand name products in adults and are considered to be bioequivalent. NSAID should be avoided in transplant patients due to potential drug interactions and increased risk associated with NSAID use; and appropriate doses of acetaminophen should be used for treatment of pain. Over-the-counter medications, such as guaifenesin and dextromethorphan, antihistamine medications, including diphenhydramine, loratadine, cetirizine, and fexofenadine, can be safely used in pediatric solid organ transplant population. Many safe and effective over-the-counter options exist for stool softening and as laxative. Diarrhea can lead to an increase in calcineurin inhibitor levels. Food can alter the absorption of immunosuppressive drugs. Several herbal products can alter immune status of the patients or alter the blood concentration of immunosuppressive drugs or may produce renal or hepatic toxicities and should be avoided in pediatric transplant recipients. It is important to educate pediatric transplant recipients and their families about not only immunosuppressive drug therapy but also about non-prescription drugs, dietary, and herbal supplement use.
(© 2020 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: cyclosporine; dietary supplement; herbal products; immunosuppression; pediatric; tacrolimus
المشرفين على المادة: 0 (Drugs, Generic)
0 (Immunosuppressive Agents)
0 (Nonprescription Drugs)
تواريخ الأحداث: Date Created: 20201103 Date Completed: 20211129 Latest Revision: 20211129
رمز التحديث: 20221213
DOI: 10.1111/petr.13881
PMID: 33142023
قاعدة البيانات: MEDLINE
الوصف
تدمد:1399-3046
DOI:10.1111/petr.13881