دورية أكاديمية
Important considerations for drugs, nutritional, and herbal supplements in pediatric solid organ transplant recipients.
العنوان: | Important considerations for drugs, nutritional, and herbal supplements in pediatric solid organ transplant recipients. |
---|---|
المؤلفون: | Pilch NA; Department of Pharmacy Practice and Outcomes Sciences, Transplant ICCE, Medical University of South Carolina, Charleston, SC, USA., Sell ML; Pediatrics/Solid Organ Transplant and Surgery, Transplant ICCE, Medical University of South Carolina, Charleston, SC, USA., McGhee W; Transplantation Ambulatory Care, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Venkataramanan R; School of Pharmacy and Medicine, Thomas Starzl Transplantation Institute, UPMC, Pittsburgh, PA, USA. |
المصدر: | Pediatric transplantation [Pediatr Transplant] 2021 Feb; Vol. 25 (1), pp. e13881. Date of Electronic Publication: 2020 Nov 03. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997- |
مواضيع طبية MeSH: | Diet, Healthy* , Dietary Supplements* , Transplant Recipients*, Immunosuppressive Agents/*therapeutic use , Nonprescription Drugs/*therapeutic use, Adolescent ; Child ; Drug Interactions ; Drugs, Generic/therapeutic use ; Humans ; Therapeutic Equivalency |
مستخلص: | Pediatric transplant recipients are on multiple prescription and non-prescription drugs. Many patients also use dietary, nutritional, and herbal supplements. This manuscript researched formulations of immunosuppressive drugs currently available and presents information on generic immunosuppressive drugs, commonly used non-prescription medications, dietary supplements, and herbal supplements. Immunosuppressive drugs are available in various formulations. Not all formulations are interchangeable. A number of FDA-approved generic formulations are available commercially in the United States. Generally generic formulations produce similar blood concentration vs time profiles compared to brand name products in adults and are considered to be bioequivalent. NSAID should be avoided in transplant patients due to potential drug interactions and increased risk associated with NSAID use; and appropriate doses of acetaminophen should be used for treatment of pain. Over-the-counter medications, such as guaifenesin and dextromethorphan, antihistamine medications, including diphenhydramine, loratadine, cetirizine, and fexofenadine, can be safely used in pediatric solid organ transplant population. Many safe and effective over-the-counter options exist for stool softening and as laxative. Diarrhea can lead to an increase in calcineurin inhibitor levels. Food can alter the absorption of immunosuppressive drugs. Several herbal products can alter immune status of the patients or alter the blood concentration of immunosuppressive drugs or may produce renal or hepatic toxicities and should be avoided in pediatric transplant recipients. It is important to educate pediatric transplant recipients and their families about not only immunosuppressive drug therapy but also about non-prescription drugs, dietary, and herbal supplement use. (© 2020 Wiley Periodicals LLC.) |
References: | Singh AK, Narsipur SS. Cyclosporine: a commentary on brand name versus generic formulation exchange. J Transplant. 2011(480642):.1-6. Patel N, Cook A, Greenhalgh E, Rech MA, Rusinak J, Heinrich L. Overview of extended release tacrolimus in solid organ transplantation. World J Transplant. 2016;6(1):144-154. Tremblay S, Nigro V, Weinberg J, et al. A steady state head to head pharmacokinetic comparison of all FK506 (tacrolimus) formulations: an open label prospective randomized two arm three period crossover study. Am J Transplant. 2017;17:432-442. Heffron TG, Pescovitz MD, Florman S, et al. Once-daily tacrolimus extended-release formulation: 1-year post-conversion in stable pediatric liver transplant recipients. Am J Transplant. 2007;7(6):1609-1615. Pape L, Heidotting N, Ahlenstiel T. Once-daily tacrolimus extended-release formulation: 1 year after conversion in stable pediatric kidney transplant recipients. Int J Nephrol. 2011;2011:126251. Szempruch KR, Westreich KD, Toledo AH. Early Use of Tacrolimus Extended-Release in a Pediatric Kidney Transplant Recipient. Exp Clin Transplant. 2017. https://doi.org/10.6002/ect.2017.0195. Johnston A, Holt D. Bioequivalence of enteric coated mycophenolate sodium and mycophenolate mofetil: a meta analysis of three studies in stable renal transplant recipients. Transplantation. 2006;15:1413-1418. Medeiros M, Lumini J, Stern N, et al. Generic immunosuppression. Pediatr Nephrol. 2018;33:1123-1131. Filler G, Kobrzynski M. The problem with generic immunosuppressants. Pediatr Transplant. 2014;15:69. Riva N, Caceres PC, Ibanez J, et al. Therapeutic monitoring of pediatric renal transplant patients with conversion to generic cyclosporine. Int J Clin Pharm. 2014;36:779-786. Petan JA, Undre N, First R, et al. Physiochemical properties of generic formulations of tacrolimus in Mexico. Transplant Proc. 2008;40:1439-1442. Jacobo-Cabral CO, García-Roca P, Romero-Tejeda EM, et al. Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation. Br J Clin Pharmacol. 2015;80(4):630-641. Alloway RR, Vinks AA, Fukuda T, et al. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: a randomized, crossover clinical trial. PLoS Med. 2017;14(11):e1002428. Abdulnour HA, Araya CE, Dharnidhararka VR. Comparison of generic tacrolimus and Prograf drug levels in a pediatric kidney program: brief communication. Pedriatr Transplant. 2010;14:1007-1011. Duong SQ, Lal AK, Joshi R, et al. Transition from brand to generic tacrolimus is associated with a decrease in trough blood concentrations in pediatric heart transplant patients. Pediatr Transplant. 2015;19:911-917. Madian AG, Panigrahi A, Perera MA, et al. Case report: inability to achieve therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution. BMC Pharmacol Toxicol. 2014;15:69. Jacobo-Cabral JO, Garcia-Roca P, Reyes H, et al. Limustin® a non-innovator formulation yields reduced drug exposure in pediatric renal transplant recipients. Peditar Transplant. 2014;18:706-713. Zhao W, Farhoury M, Baudouin V, et al. Population pharmacokinetics and pharmacogenetics of once daily prolonged release formulation in pediatric and adolescent kidney transplant recipients. Eur J Clin Pharmacol. 2013;69:189-195. Jacobson PA, Johnson CE, West NJ, Foster JA. Stability of tacrolimus in an extemporaneously compounded oral liquid. Am J Health Syst Pharm. 1997;54(2):178-180. Han J, Beeton A, Long PF, et al. Physical and microbiological stability of an extemporaneous tacrolimus suspension for paediatric use. J Clin Pharm Ther. 2006;31:167-172. Undre N, Dickinson J. Relative bioavailability of single doses of prolonged-release tacrolimus administered as a suspension, orally or via a nasogastric tube, compared with intact capsules: a phase 1 study in healthy participants. BMJ Open. 2017;7(4):e012252. Sunder-Plassmann G, Reinke P, Rath T, et al. Comparative pharmacokinetic study of two mycophenolate formulations in stable kidney transplant patients. Transplant Int. 2012;25:680-686. Masri MA, Andrysek T, Rizk S, et al. The role of generics in transplantation: TM-MMF versus cellcept in healthy volunteers. Transplant Proc. 2004;36:84-85. Patel S, Chauhan V, Mandal J, et al. Single dose two way crossover bioequivalence study of mycophenolate mofetil 500 mg tablets under fasting conditions in healthy male subjects. Clin Ther. 2011;33(3):378-390. Hong SK, Lee KW, Yoon KC, et al. Efficacy and safety of generic mycophenolate mofetil (My-rept) 500-milligram tablets in primary liver transplant recipients. Transplant Proc. 2017;49(6):1402-1408. Gonzalez-Ramirez R, Gozalez-Banuelos J, Villa Mde L, et al. Bioavailability of a generic of the immunosuppressive agent mycophenolate mofetil in pediatric patients. Pediatr Transplant. 2014;18:568-574. Reigner B, Grange S, Bentley D, et al. Generics in transplantation medicine: randomized comparison of innovator and substitution products containing mycophenolate mofetil. Int J Clin Pharmacol Ther. 2019;57(10):506-519. Mulka-Gierek M, Foroncewicz B, Pączek L, et al. Nonsteroidal anti-inflammatory drugs and analgesics used by kidney transplant recipients. Ann Transplant. 2018;23:153-159. Mulka-Gierek M, Foroncewicz B, Florczak M, Pączek L, Krawczyk M, Mucha K. The use of nonsteroidal anti-inflammatory drugs and analgesics by liver transplant recipients. J Clin Nurs. 2016;25(7-8):1001-1005. Helderman J, Goral S. Gastrointestinal complications of transplant immunosuppression. J Am Soc Nephrol. 2002;13:277-287. Afrin® (oxymetazoline) [package insert] Whippany, NJ, Bayer November 2019. Infants’ Simethicone Drops (simethicone) [package insert] Allegan, MI, L. Perrigo Company, November 2018. Pound CM, Blair B, Canadian Paediatric Society, Nutrition and Gastroenterology Committee, Ottawa, Ontario. Energy and sports drinks in children and adolescents. Paediatr Child Health. 2017;22:406-410. Nehlig A. Interindividual differences in caffeine metabolism and factors driving caffeine consumption. Pharmacol Rev. 2018;70:384-411. Jung DE, Joshi SM, Berg AT. How do you keto? Survey of North American pediatric ketogenic diet centers. J Child Neurol. 2015;30:868-873. McNally MA, Pyzik PL, Rubenstein JE, Hamdy RF, Kossoff EH. Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet. Pediatrics. 2009;124:e300-e304. Prograf (Tacrolimus) [package insert] Northbrook, IL, Astellas Pharma US Inc, December 2018. Envarsus XR [package insert] Cary, NC, Veloxis Pharmaceuticals Inc, December 2018. Neoral (Cyclosporine soft capsule) [package insert] East Hanover, NJ, Novartis Pharmaceuticals Corporation, March 2015. Cellcept (Mycophenolate mofetil) [package insert] South San Francisco, CA, Genentech USA Inc, December 2019. Myfortic (Mycophenolic Acid Sodium) [package insert] East Hanover, NJ, Novartis Pharmaceuticals Corporation, April 2016. Zortress (everolimus) [package insert] East Hanover, NJ, Novartis Pharmaceuticals Corporation, January 2018. Longo R, Peri C, Cricri D, et al. Ketogenic diet: a new light shining on old but gold biochemistry. Nutrients. 2019;11:2497. Lui K, Liu B, Heilbronn LK. Intermittent fasting: what questions should we be asking? Physio Behav. https://doi.org/10.1016/j.physbeh.2020.112827. Jane L, Atkinson G, Jamie V, Hamilton S, Waller G, Harrison S. Intermittent fasting interventions for the treatment of overweight and obesity in adults aged 18 years and over: a systematic review protocol. JBI Database Syst Rev Implement Rep. 2015;13:60-68. Harris L, Hamilton S, Azevedo LB, et al. Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis. JBI Database Syst Rev Implement Rep. 2018;16:507-547. Jorgenson MR, Descourouez JL, Siodlak M, Tjugum S, Rice JP, Fernandez LA. Efficacy and safety of probiotics and synbiotics in liver transplantation. Pharmacotherapy. 2018;38:758-768. Grat M, Wronka KM, Lewandowski Z, et al. Effects of continuous use of probiotics before liver transplantation: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2017;36:1530-1539. Popiel KY, Wong P, Lee MJ, Langelier M, Sheppard DC, Vinh DC. Invasive Saccharomyces cerevisiae in a liver transplant patient: case report and review of infection in transplant recipients. Transpl Infect Dis. 2015;17:435-441. Falci DR, Rigatto MH, Cantarelli VV, Zavascki AP. Lactobacillus Rhamnosus bacteremia in a kidney transplant recipient. Transpl Infect Dis. 2015;17:610-612. Mantegazza C, Molinari P, D’Auria E, Sonnino M, Morelli L, Vincenzo Zuccotti G. Probiotics and antibiotics-associated diarrhea in children: a review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment. Pharmacol Res. 2018;128:63-72. Ałtyn I, Twarużek M. Mycotoxin contamination concerns of herbs and medicinal plants. Toxins. 2020;12(3):182. Foroncewicz B, Mucha K, Gryszkiewicz J, et al. Dietary supplements and herbal preparations in renal and liver transplant recipients. Transplant Proc. 2011;43:2935-2937. Brewer CT, Chen T. Hepatotoxicity of herbal supplements mediated by modulation of cytochrome P450. Int J Mol Sci. 2017;18(11):2353. Awortwe C, Makiwane M, Reuter H, Muller C, Louw J, Rosenkranz B. Critical evaluation of causality assessment of herb-drug interactions in patients. Br J Clin Pharmacol. 2018;84(4):679-693. Li J, Chen S, Qin X, et al. Wuzhi Tablet (Schisandra sphenanthera extract) is a promising tacrolimus-sparing agent for renal transplant recipients who are CYP3A5 expressers: a two-phase prospective study. Drug Metab Dispos. 2017;45(11):1114-1119. Xu W, Choi H, Huang L. State of Panax ginseng research: a global analysis. Molecules. 2017;22:1518. Pantano F, Tittarelli R, Mannocchi G, et al. Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat. Int J Mol Sci. 2016;17(4):580. Madish A, Melderis H, Mayr G, Sassin I, Hotz J. A plant extract and its modified preparation in functional dyspepsia. Results of a double-blind placebo-controlled comparative study. Z Gastroenterol. 2001;39:511-517. The Joint Commission Sentinel Event Alert, Issue 35, Jan 25, 2006. Linde K, Berner M, Kriston L. St John's wort for major depression. Cochrane Database Syst Rev. 2008.4. https://doi.org/10.1002/14651858.CD000448.pub3. Nicolussi S, Drewe J, Butterweck V, Meyer zu Schwabedissen HE. Clinical relevance of St. John's wort drug interactions revisited. Br J Pharmacol. 2020;177:1212-1226. |
فهرسة مساهمة: | Keywords: cyclosporine; dietary supplement; herbal products; immunosuppression; pediatric; tacrolimus |
المشرفين على المادة: | 0 (Drugs, Generic) 0 (Immunosuppressive Agents) 0 (Nonprescription Drugs) |
تواريخ الأحداث: | Date Created: 20201103 Date Completed: 20211129 Latest Revision: 20211129 |
رمز التحديث: | 20221213 |
DOI: | 10.1111/petr.13881 |
PMID: | 33142023 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!