دورية أكاديمية
أعرض في EDS

Visual contrast sensitivity could be an early marker of diabetic retinopathy.

التفاصيل البيبلوغرافية
العنوان: Visual contrast sensitivity could be an early marker of diabetic retinopathy.
المؤلفون: Pramanik S; Institute of Post Graduate Medical Education and Research (IPGMER), 244 Acharya Jagadish Chandra Bose Road, Kolkata, 700020, India., Chowdhury S; Institute of Post Graduate Medical Education and Research (IPGMER), 244 Acharya Jagadish Chandra Bose Road, Kolkata, 700020, India., Ganguly U; Institute of Post Graduate Medical Education and Research (IPGMER), 244 Acharya Jagadish Chandra Bose Road, Kolkata, 700020, India., Banerjee A; Institute of Post Graduate Medical Education and Research (IPGMER), 244 Acharya Jagadish Chandra Bose Road, Kolkata, 700020, India.; ICARE Institute of Medical Sciences and Research, Haldia, 721645, India., Bhattacharya B; Institute of Post Graduate Medical Education and Research (IPGMER), 244 Acharya Jagadish Chandra Bose Road, Kolkata, 700020, India., Mondal LK; Regional Institute of Ophthalmology (RIO), Medical College and Hospital, Kolkata, 700073, India.
المصدر: Heliyon [Heliyon] 2020 Oct 26; Vol. 6 (10), pp. e05336. Date of Electronic Publication: 2020 Oct 26 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: The present study aimed to explore the early predictive marker of diabetic retinopathy (DR) and to elucidate the associated demographic, metabolic, and ocular factors. We enrolled 43 type 2 diabetic subjects with mild non-proliferative retinopathy (MNPDR), 30 diabetic subjects with no retinopathy (DNR), and 35 healthy controls (HC). The study groups showed no significant alteration in central macular thickness (CMT) and visual acuity (VA). The contrast sensitivity (CS) score was found to be significantly lower among DNR and MNPDR subjects compared to HCs (p < 0.0001). Between MNPDR and DNR subjects, the CS score was significantly lower in the former (p = 0.0036). CS score discriminated DNR subjects from HC, with 74% accuracy for the optimal threshold 0.71. The associated area under the ROC curve (AUC) is 0.82 (p < 0.0001) while the discrimination rule has 66% sensitivity and 80% specificity. The CS score also discriminated MNPDR subjects from DNR with 64% accuracy for the optimal threshold 0.53. The associated AUC is 0.65 (p < 0.023) and the rule has 86% sensitivity and 33% specificity. According to best subset regression analysis, not only glycaemic parameters but also lipid parameters [low-density lipoprotein cholesterol (LDL-C) (p = 0.045) and triglycerides (TG) (p = 0.0005)] were found to be significant predictors of CS. CMT (p = 0.058) was another marginally significant predictor of CS. CS may be used as an early predictive marker for DR. So, not only hyperglycemia, but also hyperlipidemia seems to significantly affect retinal CS function in diabetes.
(© 2020 Published by Elsevier Ltd.)
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فهرسة مساهمة: Keywords: Central macular thickness; Contrast sensitivity; Diabetic retinopathy; Hyperlipidemia; Ophthalmology; Visual acuity
تواريخ الأحداث: Date Created: 20201104 Latest Revision: 20201105
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7591734
DOI: 10.1016/j.heliyon.2020.e05336
PMID: 33145449
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2020.e05336