دورية أكاديمية
Development of Chlorhexidine Digluconate and Lippia sidoides Essential Oil Loaded in Microemulsion for Disinfection of Dental Root Canals: Substantivity Profile and Antimicrobial Activity.
| العنوان: | Development of Chlorhexidine Digluconate and Lippia sidoides Essential Oil Loaded in Microemulsion for Disinfection of Dental Root Canals: Substantivity Profile and Antimicrobial Activity. |
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| المؤلفون: | Santana Neto MC; Graduate Program in Dentistry, Federal University of Piaui Ministro Petrônio Portella Campus, Bloco 5 Ininga, Teresina, PI, 64049-550, Brazil., Costa MLVA; Graduate Program in Dentistry, Federal University of Piaui Ministro Petrônio Portella Campus, Bloco 5 Ininga, Teresina, PI, 64049-550, Brazil., Fialho PHDS; Graduate Program in Dentistry, Federal University of Piaui Ministro Petrônio Portella Campus, Bloco 5 Ininga, Teresina, PI, 64049-550, Brazil., Lopes GLN; Graduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina, PI, Brazil., Figueiredo KA; Institute of Education, Science and Technology of Piauí, Piauí Federal Institute, Teresina, PI, Brazil., Pinheiro IM; Graduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina, PI, Brazil., de Lima SG; Laboratory of Organic Geochemistry, Federal University of Piauí, Teresina, PI, Brazil., Nunes RS; Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, Aracaju, SE, Brazil., Quelemes PV; Graduate Program in Dentistry, Federal University of Piaui Ministro Petrônio Portella Campus, Bloco 5 Ininga, Teresina, PI, 64049-550, Brazil., Carvalho ALM; Graduate Program in Dentistry, Federal University of Piaui Ministro Petrônio Portella Campus, Bloco 5 Ininga, Teresina, PI, 64049-550, Brazil. aluismenezes@yahoo.com.br. |
| المصدر: | AAPS PharmSciTech [AAPS PharmSciTech] 2020 Nov 04; Vol. 21 (8), pp. 302. Date of Electronic Publication: 2020 Nov 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000- |
| مواضيع طبية MeSH: | Anti-Infective Agents, Local/*administration & dosage , Chlorhexidine/*analogs & derivatives , Lippia/*chemistry , Oils, Volatile/*administration & dosage , Root Canal Irrigants/*administration & dosage, Anti-Bacterial Agents/administration & dosage ; Chlorhexidine/administration & dosage ; Dental Pulp Cavity/drug effects ; Disinfection ; Enterococcus faecalis/drug effects ; Enterococcus faecalis/isolation & purification ; Humans ; Microbial Sensitivity Tests |
| مستخلص: | The dental intracanal disinfection is crucial to achieve the success of endodontic treatment, avoiding the maintenance of endodontic infections. Chlorhexidine digluconate can act as an irrigating agent for it. However, it can cause tissue irritation in high concentrations. Therefore, combinations with other antimicrobial agents and more efficient therapeutic alternatives are studied, which make it possible to administer drugs more safely and with minimal adverse effects. Thus, the objective of this study was the development of a microemulsion containing chlorhexidine digluconate and essential oil of Lippia sidoides to be used for disinfection of dental root canals and to evaluate its profile of substantivity and antimicrobial activity. The microemulsions were obtained through phase diagrams, using the spontaneous formation method. We completed a physical-chemical characterization and evaluate the stability of the microemulsions, in addition to the substantivity profile in a bovine root dentin model, and in vitro antibacterial effect on Enterococcus faecalis. A method for quantifying chlorhexidine was developed using UV-Vis spectroscopy. The microemulsions showed acid pH, conductivity above 1.3 μScm -1 , and dispersion index similar to water. The microemulsions showed antimicrobial inhibition halos similar to the commercial gel conventionally used, but with four times more substantivity to dentinal tissues. Microemulsions were obtained as a therapeutic alternative to formulations available on the market, presenting themselves as a system with great potential for the administration of drugs for disinfection of root canals. |
| فهرسة مساهمة: | Keywords: endodontics; medicinal plants; nanotechnology; root canal irrigants |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Anti-Infective Agents, Local) 0 (Oils, Volatile) 0 (Root Canal Irrigants) MOR84MUD8E (chlorhexidine gluconate) R4KO0DY52L (Chlorhexidine) |
| تواريخ الأحداث: | Date Created: 20201104 Date Completed: 20210111 Latest Revision: 20210111 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1208/s12249-020-01842-6 |
| PMID: | 33146782 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1530-9932 |
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| DOI: | 10.1208/s12249-020-01842-6 |