دورية أكاديمية
Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion.
| العنوان: | Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion. |
|---|---|
| المؤلفون: | Koppelmans V; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. vincent.koppelmans@utah.edu.; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. vincent.koppelmans@utah.edu.; Department of Psychiatry, University of Utah, Salt Lake City, USA. vincent.koppelmans@utah.edu., van der Willik KD; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Aleman BMP; Department of Radiation Oncology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands., van Leeuwen FE; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Arshi B; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Schagen SB; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Department of Psychology, Brain and Cognition, University of Amsterdam, Nieuwe Achtergracht 129-B, 1018 WS, Amsterdam, The Netherlands. |
| المصدر: | Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Feb; Vol. 186 (1), pp. 167-176. Date of Electronic Publication: 2020 Nov 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Original Publication: The Hague ; Boston : M. Nijhoff, c1981- |
| مواضيع طبية MeSH: | Breast Neoplasms*/complications , Breast Neoplasms*/drug therapy , Carotid Intima-Media Thickness*, Brain/diagnostic imaging ; Carotid Arteries/diagnostic imaging ; Female ; Humans ; Perfusion ; Risk Factors |
| مستخلص: | Purpose: Breast cancer treatment has been associated with vascular pathology. It is unclear if such treatment is also associated with long-term cerebrovascular changes. We studied the association between radiotherapy and chemotherapy with carotid pathology and brain perfusion in breast cancer survivors. Methods: We included 173 breast cancer survivors exposed to radiotherapy and chemotherapy, assessed ± 21.2 years after cancer diagnosis, and 346 age-matched cancer-free women (1:2) selected from the population-based Rotterdam Study. Outcome measures were carotid plaque score, intima-media thickness (IMT), total cerebral blood flow (tCBF), and brain perfusion. Additionally, we investigated the association between inclusion of the carotid artery in the radiation field (no/small/large part), tumor location, and these outcome measures within cancer survivors. Results: Cancer survivors had lower tCBF (- 19.6 ml/min, 95%CI - 37.3;- 1.9) and brain perfusion (- 2.5 ml/min per 100 ml, 95%CI - 4.3;- 0.7) than cancer-free women. No statistically significant group differences were observed regarding plaque score or IMT. Among cancer survivors, a large versus a small part of the carotid artery in the radiation field was associated with a higher IMT (0.05, 95%CI0.01;0.09). Also, survivors with a right-sided tumor had lower left carotid plaque score (- 0.31, 95%CI - 0.60;- 0.02) and higher brain perfusion (3.5 ml/min per 100 ml, 95%CI 0.7;6.2) than those with a left-sided tumor. Conclusions: On average two decades post-diagnosis, breast cancer survivors had lower tCBF and brain perfusion than cancer-free women. Also, survivors with a larger area of the carotid artery within the radiation field had a larger IMT. Future studies should confirm if these cerebrovascular changes underlie the frequently observed cognitive problems in cancer survivors. |
| References: | Breast Cancer Res Treat. 2012 Apr;132(3):1099-106. (PMID: 22205140) Int J Radiat Oncol Biol Phys. 2015 Jul 1;92(3):642-9. (PMID: 25936809) Cancer Control. 2002 Mar-Apr;9(2 Suppl):16-27. (PMID: 11965227) Lancet Oncol. 2005 Jun;6(6):401-10. (PMID: 15925818) PLoS One. 2014 May 09;9(5):e96713. (PMID: 24816641) J Neuroimaging. 2005 Apr;15(2):150-6. (PMID: 15746227) J Am Coll Cardiol. 2010 Mar 23;55(12):1237-1239. (PMID: 20298931) Circulation. 2010 Sep 21;122(12):1167-75. (PMID: 20823388) Radiother Oncol. 2014 Jan;110(1):31-8. (PMID: 24044796) Can J Cardiol. 2016 Jul;32(7):852-62. (PMID: 26968393) J Clin Oncol. 2006 Dec 1;24(34):5388-94. (PMID: 17088569) Korean J Intern Med. 2019 May;34(3):579-587. (PMID: 28838227) Cancer Treat Rev. 2012 Aug;38(5):473-83. (PMID: 21982720) Radiother Oncol. 2011 Aug;100(2):157-9. (PMID: 21884942) Clin Oncol (R Coll Radiol). 2015 Nov;27(11):621-9. (PMID: 26133462) J Am Heart Assoc. 2015 Nov 09;4(11):. (PMID: 26553214) Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):595-604. (PMID: 30385276) Tex Heart Inst J. 2011;38(3):263-5. (PMID: 21720467) J Clin Oncol. 1999 Aug;17(8):2365-70. (PMID: 10561298) Stroke. 2014 Nov;45(11):3226-30. (PMID: 25228259) J Clin Oncol. 2016 Mar 1;34(7):677-83. (PMID: 26527786) Circulation. 2007 Jan 30;115(4):459-67. (PMID: 17242284) Stroke. 2001 Jul;32(7):1532-8. (PMID: 11441197) Eur J Epidemiol. 2015 Dec;30(12):1299-315. (PMID: 26650042) J Am Heart Assoc. 2019 Apr 2;8(7):e011565. (PMID: 30905232) Eur J Cancer. 2011 Nov;47(17):2531-6. (PMID: 21745734) J Cereb Blood Flow Metab. 2008 Feb;28(2):412-9. (PMID: 17622253) Int J Cardiol. 2010 Sep 24;144(1):3-15. (PMID: 20399520) Circulation. 2017 Aug 22;136(8):719-728. (PMID: 28588075) Neuroimage. 2007 Aug 1;37(1):71-81. (PMID: 17572111) J Am Heart Assoc. 2019 May 7;8(9):e011630. (PMID: 31057061) Crit Rev Oncol Hematol. 2013 Oct;88(1):87-101. (PMID: 23768778) Eur J Epidemiol. 2020 May;35(5):483-517. (PMID: 32367290) Am J Cardiol. 2016 Sep 1;118(5):771-6. (PMID: 27392510) Int Rev Psychiatry. 2014 Feb;26(1):102-13. (PMID: 24716504) J Clin Oncol. 2006 Jun 20;24(18):2779-85. (PMID: 16702581) Circulation. 2004 Mar 9;109(9):1089-94. (PMID: 14993130) J Natl Cancer Inst. 2007 Mar 7;99(5):365-75. (PMID: 17341728) J Clin Oncol. 2012 Apr 1;30(10):1080-6. (PMID: 22370315) Stroke. 1999 Apr;30(4):841-50. (PMID: 10187889) N Engl J Med. 2013 Mar 14;368(11):987-98. (PMID: 23484825) |
| معلومات مُعتمدة: | NKI-20157737 KWF Kankerbestrijding (NL) |
| فهرسة مساهمة: | Keywords: Brain perfusion; Breast cancer; Carotid plaques; Chemotherapy; Intima-media thickness; Radiotherapy |
| تواريخ الأحداث: | Date Created: 20201105 Date Completed: 20210623 Latest Revision: 20210623 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7940271 |
| DOI: | 10.1007/s10549-020-05990-y |
| PMID: | 33151443 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-7217 |
|---|---|
| DOI: | 10.1007/s10549-020-05990-y |