دورية أكاديمية
Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion.
العنوان: | Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion. |
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المؤلفون: | Koppelmans V; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. vincent.koppelmans@utah.edu.; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. vincent.koppelmans@utah.edu.; Department of Psychiatry, University of Utah, Salt Lake City, USA. vincent.koppelmans@utah.edu., van der Willik KD; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Aleman BMP; Department of Radiation Oncology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands., van Leeuwen FE; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Arshi B; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Schagen SB; Department of Psychosocial Research & Epidemiology, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Department of Psychology, Brain and Cognition, University of Amsterdam, Nieuwe Achtergracht 129-B, 1018 WS, Amsterdam, The Netherlands. |
المصدر: | Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Feb; Vol. 186 (1), pp. 167-176. Date of Electronic Publication: 2020 Nov 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Original Publication: The Hague ; Boston : M. Nijhoff, c1981- |
مواضيع طبية MeSH: | Breast Neoplasms*/complications , Breast Neoplasms*/drug therapy , Carotid Intima-Media Thickness*, Brain/diagnostic imaging ; Carotid Arteries/diagnostic imaging ; Female ; Humans ; Perfusion ; Risk Factors |
مستخلص: | Purpose: Breast cancer treatment has been associated with vascular pathology. It is unclear if such treatment is also associated with long-term cerebrovascular changes. We studied the association between radiotherapy and chemotherapy with carotid pathology and brain perfusion in breast cancer survivors. Methods: We included 173 breast cancer survivors exposed to radiotherapy and chemotherapy, assessed ± 21.2 years after cancer diagnosis, and 346 age-matched cancer-free women (1:2) selected from the population-based Rotterdam Study. Outcome measures were carotid plaque score, intima-media thickness (IMT), total cerebral blood flow (tCBF), and brain perfusion. Additionally, we investigated the association between inclusion of the carotid artery in the radiation field (no/small/large part), tumor location, and these outcome measures within cancer survivors. Results: Cancer survivors had lower tCBF (- 19.6 ml/min, 95%CI - 37.3;- 1.9) and brain perfusion (- 2.5 ml/min per 100 ml, 95%CI - 4.3;- 0.7) than cancer-free women. No statistically significant group differences were observed regarding plaque score or IMT. Among cancer survivors, a large versus a small part of the carotid artery in the radiation field was associated with a higher IMT (0.05, 95%CI0.01;0.09). Also, survivors with a right-sided tumor had lower left carotid plaque score (- 0.31, 95%CI - 0.60;- 0.02) and higher brain perfusion (3.5 ml/min per 100 ml, 95%CI 0.7;6.2) than those with a left-sided tumor. Conclusions: On average two decades post-diagnosis, breast cancer survivors had lower tCBF and brain perfusion than cancer-free women. Also, survivors with a larger area of the carotid artery within the radiation field had a larger IMT. Future studies should confirm if these cerebrovascular changes underlie the frequently observed cognitive problems in cancer survivors. |
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معلومات مُعتمدة: | NKI-20157737 KWF Kankerbestrijding (NL) |
فهرسة مساهمة: | Keywords: Brain perfusion; Breast cancer; Carotid plaques; Chemotherapy; Intima-media thickness; Radiotherapy |
تواريخ الأحداث: | Date Created: 20201105 Date Completed: 20210623 Latest Revision: 20210623 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7940271 |
DOI: | 10.1007/s10549-020-05990-y |
PMID: | 33151443 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7217 |
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DOI: | 10.1007/s10549-020-05990-y |