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A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men.

التفاصيل البيبلوغرافية
العنوان: A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men.
المؤلفون: Kondrakhina IN; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, Moscow, Russian Federation, 107076., Verbenko DA; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, Moscow, Russian Federation, 107076., Zatevalov AM; G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Admiral Makarov St., 10, 125212, Moscow, Russian Federation., Gatiatulina ER; All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, Russian Federation, 117216., Nikonorov AA; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, Moscow, Russian Federation, 107076. nikonorov_all@mail.ru., Deryabin DG; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, Moscow, Russian Federation, 107076., Kubanov AA; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, Moscow, Russian Federation, 107076.
المصدر: Biological trace element research [Biol Trace Elem Res] 2021 Sep; Vol. 199 (9), pp. 3232-3241. Date of Electronic Publication: 2020 Nov 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London, Clifton, N. J.] Humana Press.
مواضيع طبية MeSH: Trace Elements*, Alopecia ; Cross-Sectional Studies ; Hair ; Humans ; Male ; Vitamins
مستخلص: Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA using direct colorimetric tests or atomic absorption spectrometry, and the influence of these parameters in the formation of various hair loss patterns. The study included 50 patients with I-IV stages of AGA divided into two groups with normal and high levels of dihydrotestosterone compared with 25 healthy individuals. The presence of two patterns of pathological hair loss in the androgen-dependent (parietal) and androgen-independent (occipital) areas of the scalp was confirmed. It was shown that all patients with AGA have a deficiency of elements (Zn, Cu, Mg, Se) and vitamins (B12, E, D, folic acid). However, the hair loss rate was not due to their content. А positive interrelation between quantitative trichogram parameters in the occipital region and iron metabolism in pairs "hair density vs Fe" and "hair diameter vs ferritin" was shown. In turn, in the parietal region, an inverse correlation of hair diameter with plasma Cu level was found, the most pronouncing in patients with high levels of dihydrotestosterone. The obtained results indicate the importance of multiple micronutrient deficiencies in the AGA occurrence accompanied by the existence of two different hair loss patterns, differently related to the content of certain trace elements and androgens in the blood.
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فهرسة مساهمة: Keywords: Androgenic alopecia; Dihydrotestosterone; Hair loss pattern; Trace elements; Vitamins
المشرفين على المادة: 0 (Trace Elements)
0 (Vitamins)
تواريخ الأحداث: Date Created: 20201105 Date Completed: 20210707 Latest Revision: 20210707
رمز التحديث: 20221213
DOI: 10.1007/s12011-020-02468-2
PMID: 33151470
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0720
DOI:10.1007/s12011-020-02468-2