دورية أكاديمية
أعرض في EDS

A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models.

التفاصيل البيبلوغرافية
العنوان: A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models.
المؤلفون: Zarghami N; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Soto MS; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Perez-Balderas F; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Khrapitchev AA; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Karali CS; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Johanssen VA; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Ansorge O; Department of Clinical Neuropathology, John Radcliffe Hospital, Oxford, UK., Larkin JR; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Sibson NR; Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.
المصدر: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2021 Jul; Vol. 41 (7), pp. 1592-1607. Date of Electronic Publication: 2020 Nov 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : Thousand Oaks, CA : SAGE Publications
Original Publication: New York : Raven Press, c1981-
مواضيع طبية MeSH: Activated-Leukocyte Cell Adhesion Molecule/*chemistry , Adenocarcinoma of Lung/*drug therapy , Antibodies, Monoclonal/*pharmacology , Brain Neoplasms/*drug therapy , Breast Neoplasms/*drug therapy , Contrast Media/*metabolism , Melanoma/*drug therapy, Activated-Leukocyte Cell Adhesion Molecule/metabolism ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/pathology ; Animals ; Apoptosis ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Ferric Compounds/chemistry ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Magnetic Resonance Imaging ; Melanoma/metabolism ; Melanoma/pathology ; Mice ; Mice, SCID ; Neoplasm Invasiveness ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
مستخلص: Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molecular level. Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. The aim of this study, therefore, was to develop a novel molecular MRI contrast agent, by conjugating anti-ALCAM antibodies to microparticles of iron oxide (MPIO), for detection of endothelial ALCAM expression in vivo . Binding specificity of ALCAM-MPIO was demonstrated in vitro under static and flow conditions. Subsequently, in a proof-of-concept study, mouse models of brain metastasis were induced by intracardial injection of brain-tropic human breast carcinoma, lung adenocarcinoma or melanoma cells to upregulate endothelial ALCAM. At selected time-points, mice were injected intravenously with ALCAM-MPIO, and ALCAM-MPIO induced hypointensities were observed on T 2 *-weighted images in all three models. Post-gadolinium MRI confirmed an intact blood-brain barrier, indicating endoluminal binding. Correlation between endothelial ALCAM expression and ALCAM-MPIO binding was confirmed histologically. Statistical analysis indicated high sensitivity (80-90%) and specificity (79-83%) for detection of endothelial ALCAM in vivo with ALCAM-MPIO. Given reports of endothelial ALCAM upregulation in numerous neurological diseases, this advance in our ability to image ALCAM in vivo may yield substantial improvements for both diagnosis and targeted therapy.
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معلومات مُعتمدة: 16945 United Kingdom CRUK_ Cancer Research UK; MR/L022656/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: CD166); Magnetic resonance imaging; activated leukocyte cell adhesion molecule (ALCAM; brain metastasis; inflammation; molecular imaging
المشرفين على المادة: 0 (Activated-Leukocyte Cell Adhesion Molecule)
0 (Antibodies, Monoclonal)
0 (Contrast Media)
0 (Ferric Compounds)
1K09F3G675 (ferric oxide)
تواريخ الأحداث: Date Created: 20201106 Date Completed: 20210820 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC8217895
DOI: 10.1177/0271678X20968943
PMID: 33153376
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-7016
DOI:10.1177/0271678X20968943