دورية أكاديمية
Efficacy of nifedipine versus hydralazine in the management of severe hypertension in pregnancy: A randomised controlled trial.
| العنوان: | Efficacy of nifedipine versus hydralazine in the management of severe hypertension in pregnancy: A randomised controlled trial. |
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| المؤلفون: | Adebayo JA; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Nwafor JI; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Lawani LO; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Esike CO; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Olaleye AA; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Adiele NA; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria. |
| المصدر: | The Nigerian postgraduate medical journal [Niger Postgrad Med J] 2020 Oct-Dec; Vol. 27 (4), pp. 317-324. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: published by Wolters Kluwer-Medknow for the Nigerian Postgraduate Medical College of Nigeria Country of Publication: Nigeria NLM ID: 9613595 Publication Model: Print Cited Medium: Print ISSN: 1117-1936 (Print) NLM ISO Abbreviation: Niger Postgrad Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2015- > : Mumbai : published by Wolters Kluwer-Medknow for the Nigerian Postgraduate Medical College of Nigeria Original Publication: Ebute Metta, Lagos, Nigeria : National Postgraduate Medical College of Nigeria, [1994- |
| مواضيع طبية MeSH: | Hypertension, Pregnancy-Induced/*drug therapy, Administration, Oral ; Antihypertensive Agents/adverse effects ; Blood Pressure/drug effects ; Female ; Humans ; Hydralazine/pharmacology ; Hydralazine/therapeutic use ; Nifedipine/pharmacology ; Nifedipine/therapeutic use ; Nigeria ; Pregnancy |
| مستخلص: | Background: Despite the availability of effective antihypertensive drugs, the quality of evidence regarding the best antihypertensive agent for the treatment of hypertensive emergencies in pregnancy is still poor. Aim: The aim of this study was to compare the efficacy and side effects of oral nifedipine and intravenous hydralazine for control of blood pressure (BP) in severe hypertension in pregnancy. Materials and Methods: An open-label, parallel, randomised, controlled trial of 78 pregnant women (≥28 weeks' gestation) with severe hypertension was conducted. Severe hypertension was defined as systolic BP of 160 mmHg or above and/or diastolic BP of 110 mmHg or above. They were randomly (1:1 ratio) administered oral nifedipine 20 mg or intravenous hydralazine 10 mg every 30 min up to 5 doses or until the target BP of 140-150 mmHg systolic and 90-100 mmHg diastolic was achieved. Intravenous labetalol was given if the primary treatment failed. The primary outcome measure was the number of doses needed to achieve targeted BP. The secondary outcome measures were the time needed to achieve desired BP, maternal adverse effects and perinatal outcome. Results: The sociodemographic characteristics did not differ between the two study groups. The average number of dosages (nifedipine; 1.4 ± 0.6 vs. hydralazine; 1.7 ± 0.5, P = 0.008) needed to control the BP was lower in the nifedipine arm. Time (min) taken to control the BP was similar between the groups (hydralazine; 43.7 ± 19.7 vs. nifedipine; 51.2 ± 18.9, P = 0.113). Adverse maternal and perinatal effects did not differ in the study groups. Conclusion: Oral nifedipine and intravenous hydralazine showed comparable efficacy in the BP control in the severe hypertensive disorders of pregnancy without significant difference in adverse maternal and perinatal outcomes. However, further studies are required to explore the role of these drugs in BP control during hypertensive emergencies in pregnancy. Clinicaltrials.gov: (Identification number: NCT04435210). Competing Interests: None |
| فهرسة مساهمة: | Keywords: Hydralazine; nifedipine; pregnancy; severe hypertension |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04435210 |
| المشرفين على المادة: | 0 (Antihypertensive Agents) 26NAK24LS8 (Hydralazine) I9ZF7L6G2L (Nifedipine) |
| تواريخ الأحداث: | Date Created: 20201106 Date Completed: 20210114 Latest Revision: 20220418 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4103/npmj.npmj_275_20 |
| PMID: | 33154284 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1117-1936 |
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| DOI: | 10.4103/npmj.npmj_275_20 |