دورية أكاديمية
أعرض في EDS

Association of -94 ATTG insertion/deletion NFkB1 and c.*126G>A NFkBIA genetic polymorphisms with oxidative and nitrosative stress biomarkers in Brazilian subjects with Parkinson's Disease.

التفاصيل البيبلوغرافية
العنوان: Association of -94 ATTG insertion/deletion NFkB1 and c.*126G>A NFkBIA genetic polymorphisms with oxidative and nitrosative stress biomarkers in Brazilian subjects with Parkinson's Disease.
المؤلفون: Baltus THL; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil. Electronic address: thiagobaltus@hotmail.com., Morelli NR; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., de Farias CC; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., Trugilo KP; Department of General Pathology, Biological Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., Okuyama NCM; Department of General Pathology, Biological Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., de Oliveira KB; Department of General Pathology, Biological Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., de Melo LB; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil; Department of Clinical Medicine Neurology, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., Smaili SM; Department of Physiotherapy, Program of Masters and Doctoral Degree in Rehabilitation Sciences, State University of Londrina, Londrina, Paraná, Brazil., Barbosa DS; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil.
المصدر: Neuroscience letters [Neurosci Lett] 2021 Jan 01; Vol. 740, pp. 135487. Date of Electronic Publication: 2020 Nov 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Scientific Publishers Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
مواضيع طبية MeSH: NF-KappaB Inhibitor alpha/*genetics , NF-kappa B p50 Subunit/*genetics , Parkinson Disease/*genetics, Aged ; Aged, 80 and over ; Biomarkers/analysis ; Brazil/epidemiology ; Female ; Gene Deletion ; Humans ; Male ; Middle Aged ; Mutagenesis, Insertional ; Nitric Oxide/metabolism ; Oxidation-Reduction ; Parkinson Disease/epidemiology ; Polymorphism, Genetic/genetics ; Reactive Nitrogen Species ; Reactive Oxygen Species
مستخلص: Parkinson's disease (PD) is a complex neurodegenerative disorder, resulting dopaminergic neuronal cell death in the substantia nigra. The disease is characterized by major motor impairment, being bradykinesia, rest tremor, rigidity and loss of postural reflexes the most common, while autonomic dysfunctions, sleep disturbances and psychiatric disorders are some of the wide range of non-motor symptoms. Several processes have been identified to be associated with disease development, such as mitochondrial dysfunction, oxidative/nitrosative stress and neuroinflammation. NF-κB is an important transcription factor that regulates several inflammatory elements and pathways, and polymorphisms on NFKB1 and NFKBIA genes can potentially influence redox balance towards a pro-oxidative frame, modulating disease progression. Evaluation of these polymorphisms in the redox status of PD subjects could provide new insights on the pathogenesis of this disorder. The study aimed to test associations of -94 in./del ATTG NFKB1 (rs28362491) and c.*126G > A NFKBIA (rs696) polymorphisms with PD development, and to test the influence of both polymorphisms on oxidative/nitrosative stress (OS/NS) parameters. A total of 110 Brazilian individuals were enrolled, being 55 subjects recruited from University Hospital of Londrina as the PD group, and 55 subjects matched for age, sex and ethnicity composed the healthy control (HC) group. NFkB1 and NFkBIA polymorphisms were genotyped by PCR-RFLP. Lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), advanced oxidation protein products (AOPP), sulfhydryl groups (SH), total radical trapping antioxidant parameter (TRAP) and paraoxonase-1 activity (PON-1) were assessed. Despite no association of polymorphisms on disease development was observed, in PD subjects the NFKB1 del/del genotype was associated with higher levels of LOOH, while NFkBIA GA and AA genotypes were associated with higher NOx levels, suggesting that NFkB plays a role in PD susceptbility. In conclusion, the prospect of genetic polymorphisms of elements involved in inflammation and OS/NS might be a new approach to unravel PD etiology.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Gene polymorphism; Inflammation; NFκB; NFκB1; NFκBIA; Oxidative stress; Parkinson disease
المشرفين على المادة: 0 (Biomarkers)
0 (NF-kappa B p50 Subunit)
0 (NFKB1 protein, human)
0 (NFKBIA protein, human)
0 (Reactive Nitrogen Species)
0 (Reactive Oxygen Species)
139874-52-5 (NF-KappaB Inhibitor alpha)
31C4KY9ESH (Nitric Oxide)
تواريخ الأحداث: Date Created: 20201108 Date Completed: 20210507 Latest Revision: 20210507
رمز التحديث: 20221213
DOI: 10.1016/j.neulet.2020.135487
PMID: 33161109
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7972
DOI:10.1016/j.neulet.2020.135487