دورية أكاديمية
[Haploidentical transplantation from a related donor as first-line treatment for fulminant aplastic anemia].
| العنوان: | [Haploidentical transplantation from a related donor as first-line treatment for fulminant aplastic anemia]. |
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| المؤلفون: | Makishima K; Department of Hematology, University of Tsukuba Hospital., Obara N; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Sakamoto T; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Kato T; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Kusakabe M; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Nishikii H; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Kurita N; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Yokoyama Y; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Sakata-Yanagimoto M; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Hasegawa Y; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba., Chiba S; Department of Hematology, University of Tsukuba Hospital.; Department of Hematology, Faculty of Medicine, University of Tsukuba. |
| المصدر: | [Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2020; Vol. 61 (10), pp. 1464-1468. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Japan Society Of Clinical Hematology Country of Publication: Japan NLM ID: 2984782R Publication Model: Print Cited Medium: Print ISSN: 0485-1439 (Print) Linking ISSN: 04851439 NLM ISO Abbreviation: Rinsho Ketsueki Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo : Japan Society Of Clinical Hematology Original Publication: Tokyo, Rinsho Ketsueki Kondankai. |
| مواضيع طبية MeSH: | Anemia, Aplastic*/therapy , Graft vs Host Disease* , Hematopoietic Stem Cell Transplantation*, Adult ; Granulocyte Colony-Stimulating Factor ; Humans ; Male ; Transplantation Conditioning ; Transplantation, Haploidentical |
| مستخلص: | Immunosuppressive therapy (IST) is the first-line treatment for young patients with severe aplastic anemia (AA) when a human leucocyte antigen (HLA)-matched related donor (MRD) is unavailable. Fulminant AA (FAA) is defined as AA with a complete absence of neutrophils at presentation and no response to granulocyte-colony stimulating factor (G-CSF) treatment. Here we report a 38-year-old male FAA patient who underwent allogeneic stem cell transplantation from an HLA haplotype-mismatched donor as first-line treatment. The patient had no remarkable disease history and was referred to our hospital because of a peritonsillar abscess and severe pancytopenia. Bone marrow biopsy revealed marked hypocellularity without dysplasia. His neutrophil count remained 0.0×10 9 /l following G-CSF administration, and he was diagnosed with FAA. His siblings were not MRDs, but his sister had haploidentical HLAs. After administering a conditioning regimen, the patient received a transplant of peripheral blood stem cells donated by his sister. Neutrophil engraftment was observed on post-transplant day 16, and he experienced acute graft-versus-host disease (grade I, skin stage 1), but no other complications were observed. Hematopoietic stem cell transplantation from an HLA haplotype-mismatched related donor may be a viable option for first-line treatment of FAA when an MRD is unavailable. |
| فهرسة مساهمة: | Keywords: Fulminant aplastic anemia; HLA haplotype-mismatch; Haploidentical transplantation; Hematopoietic stem cell transplantation |
| المشرفين على المادة: | 143011-72-7 (Granulocyte Colony-Stimulating Factor) |
| تواريخ الأحداث: | Date Created: 20201109 Date Completed: 20210114 Latest Revision: 20210114 |
| رمز التحديث: | 20221213 |
| DOI: | 10.11406/rinketsu.61.1464 |
| PMID: | 33162441 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0485-1439 |
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| DOI: | 10.11406/rinketsu.61.1464 |